Alzheimer's Disease Neuroimaging Initiative Grand Opportunity



Status:Archived
Conditions:Alzheimer Disease, Cognitive Studies
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:April 2010
End Date:December 2012

Use our guide to learn which trials are right for you!


The purpose of this study is to build upon the information obtained in the original
Alzheimer's Disease Neuroimaging Initiative (ADNI1), to examine how brain imaging technology
can be used with other tests to measure the progression of mild cognitive impairment (MCI)
and early Alzheimer's disease (AD). ADNI-GO seeks to define and characterize the mildest
symptomatic phase of AD, referred to in this study as early amnestic MCI (EMCI). This
information will aid in the early detection of AD, and in measuring the effectiveness of
treatments in future clinical trials.


This project continues the work from ADNI1, the goal of which is to test whether serial
magnetic resonance imaging (MRI), positron emission tomography (PET), other biological
markers, and clinical and neuropsychological assessments can be combined to measure the
progression of mild cognitive impairment (MCI) and early Alzheimer's disease (AD). The goal
of the study is to determine relationships among the clinical, cognitive, imaging, genetic,
and biochemical biomarker characteristics of the stage of the AD spectrum that precedes MCI,
the mildest symptomatic phase of AD, referred to here as EMCI. The ADNI-GO model posits that
AD begins with amyloid β (Aβ) deposition in the cortex, which leads to synaptic dysfunction,
neurodegeneration, and cognitive/ functional decline.

Some of the leading-edge technologies under study are brain-imaging techniques, such as
positron emission tomography (PET), including FDG-PET (which measures glucose metabolism in
the brain); PET using a radioactive compound (F-AV-45) that measures brain beta-amyloid; and
structural MRI. Brain scans are showing scientists how the brain's structure and function
change as AD starts and progresses. Biomarkers in cerebrospinal fluid are revealing other
changes that could identify which patients with MCI will develop Alzheimer's. Scientists are
looking at levels of beta-amyloid and tau in cerebrospinal fluid. (Abnormal amounts of the
amyloid and tau proteins in the brain are hallmarks of Alzheimer's disease.)

All participants from ADNI1 who are in the normal and MCI stages will continue to be
followed in ADNI-GO. The next step is to scan and analyze the brains of people with EMCI;
200 EMCI participants will be enrolled to narrow the gap between cognitively normal (CN) and
"late MCI (LMCI)" participants currently enrolled in ADNI.

The overall impact of this study will be increased knowledge concerning the sequence and
timing of events leading to MCI and AD, development of better clinical and imaging/fluid
biomarker methods for early detection and for monitoring the progression of these
conditions, and facilitation of clinical trials of treatments to slow disease progression,
ultimately contributing to the prevention of AD.


We found this trial at
49
sites
425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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43 New Scotland Avenue
Albany, New York 12208
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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1 Boston Medical Center Pl
Boston, Massachusetts 02118
617.638.8000
Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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201 East Huron Street
Chicago, Illinois 60611
(847) 491-3741
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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Chicago, IL
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5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
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1240 North Mission Road # L919
Los Angeles, California 90033
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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10515 W Santa Fe Drive
Phoenix, Arizona 85351
623-875-6500
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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1 Brookings Drive
St. Louis, Missouri 63110
 (314) 935-5000
Washington University Washington University creates an environment to encourage and support an ethos of wide-ranging...
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4000 Reservoir Road NW, Suite 120
Washington, Washington DC 20007
(202) 687-0100
Georgetown Univ Med Ctr Georgetown University Medical Center is committed to excellence in research, education...
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Washington, Washington DC 20060
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Amherst, New York 14226
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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850 Boylston Street
Chestnut Hill, Massachusetts 02467
1-800-BWH-9999
Brigham & Women's Hospital Women's Health Center At Brigham and Women
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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106 Noroton Ave
Darien, Connecticut 06820
(203) 655-9741
Darien Pediatric Associates Our office is pleased and privileged to care for your children and...
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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1 Baylor Plaza
Houston, Texas 77030
(713) 798-4951
Baylor School of Medicine Baylor College of Medicine is a health sciences university that creates...
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Irvine, California 92868
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3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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Lexington, Kentucky 40536
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10833 Le Conte Ave
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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1983 Marengo St
Los Angeles, California 90033
(323) 226-2622
Los Angeles County-USC Medical Center The origins of LAC+USC Medical Center date back to 1878,...
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Madison, Wisconsin 53706
(608) 263-2400
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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Miami Beach, Florida 33140
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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70 Washington Square S
New York, New York 10012
(212) 998-1212
New York University More than 175 years ago, Albert Gallatin, the distinguished statesman who served...
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722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Orange, California 92868
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Phoenix, Arizona 85006
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Providence, Rhode Island 02906
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200 1st St SW
Rochester, Minnesota 55905
(507) 284-2316
Mayo Clinic College of Medicine Mayo Medical School enrolls a select class of 50 medical...
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601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
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1001 Potrero Ave
San Francisco, California 94110
(415) 206-8000
San Francisco General Hospital San Francisco General Hospital and Trauma Center (SFGH) is an essential...
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San Francisco, California 94115
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West Palm Beach, Florida 33407
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1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
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