Sunitinib Malate in Treating Patients With Persistent or Recurrent Clear Cell Ovarian Cancer



Status:Active, not recruiting
Conditions:Ovarian Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/17/2019
Start Date:April 19, 2010

Use our guide to learn which trials are right for you!

A Phase II Evaluation of SU11248 (Sunitinib Malate) (NSC #736511) in the Treatment of Persistent or Recurrent Clear Cell Ovarian Carcinoma

This phase II trial studies the side effects of sunitinib malate and how well it works in
treating patients with ovarian cancer that is persistent or has come back. Sunitinib malate
may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and
by blocking blood flow to the tumor.

PRIMARY OBJECTIVES:

I. To evaluate the anti-tumor activity of SU11248 (sunitinib malate), a highly potent,
selective tyrosine kinases inhibitor, in patients with persistent or recurrent clear cell
ovarian carcinoma.

II. To examine the nature and degree of toxicity in this cohort of patients treated with this
regimen.

SECONDARY OBJECTIVES:

I. To characterize the distribution of progression-free survival and overall survival for
patients treated with SU11248 (sunitinib malate).

TERTIARY OBJECTIVES:

I. To determine the pre-cycle 1, pre-cycle 4 and off-treatment levels of pro-angiogenic
proteins (e.g., angiogenin, soluble vascular cell adhesion molecule [VCAM]-I, basic
fibroblast growth factor [bFGF], platelet-derived growth factor [PDGF], placental growth
factor [PlGF], vascular endothelial growth factor [VEGF], and hypoxia-inducible factor
[HIF]1alpha).

II. To identify changes in serum and plasma angiogenesis markers at baseline (pre-cycle 1),
during treatment (cycle 4), and at progression in association with primary and secondary
clinical endpoints associated with clinical response or progression-free survival.

OUTLINE:

Patients receive sunitinib malate orally (PO) once daily (QD) for 4 weeks. Courses repeat
every 6 weeks in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have recurrent or persistent clear cell ovarian cancer; primary tumors
must be at least 50% clear cell histomorphology in order to be eligible or have a
histologically documented recurrence with at least 50% clear cell histomorphology; in
addition, the tumors should be negative for expression of Wilms tumor (WT)-1 antigen
and estrogen receptor (ER) antigen by immunohistochemistry; appropriate tissue
sections must be available for histologic evaluation for central pathology review by
Gynecologic Oncology Group (GOG); immunohistochemical stained slides for ER and WT-1
antigen must be available for review by GOG

- If the primary tumor had at least 50% clear cell histomorphology, a biopsy of the
recurrent or persistent tumor is not required; however, immunohistochemical
studies of the primary tumor for ER and WT-1 antigens should be performed and the
slides submitted to the GOG for review; the percentage of clear cell
histomorphology must be documented in the pathology report or in an addendum to
the original report; if slides of the primary tumor are not available for review
due to disposal of slides by the histology laboratory (typically 10 years after
diagnosis), biopsy of recurrent or persistent disease is required

- If the primary tumor had less than 50% clear cell histomorphology (or if slides
of the primary tumor are not available for review), a biopsy of the recurrent or
persistent tumor is required to confirm at least 50% clear cell histomorphology
and lack of immunoreactivity for ER and WT-1 antigens by immunohistochemistry;
the percentage of involvement must be documented in the pathology report or in an
addendum to the original report

- All patients must have measurable disease as defined by Response Evaluation Criteria
In Solid Tumors (RECIST) 1.1; measurable disease is defined as at least one lesion
that can be accurately measured in at least one dimension (longest diameter to be
recorded); each lesion must be >= 10 mm when measured by computed tomography (CT),
magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm
when measured by chest x-ray; lymph nodes must be >= 15 mm in short axis when measured
by CT or MRI

- Patients must have at least one "target lesion" to be used to assess response on this
protocol as defined by RECIST 1.1; tumors within a previously irradiated field will be
designated as "non-target" lesions unless progression is documented or a biopsy is
obtained to confirm persistence at least 90 days following completion of radiation
therapy; thus, a confirmed biopsy in an irradiated area at a date longer than 90 days
post-completion of radiation can be considered a target lesion to assess progression
and response

- Patients must have had one prior platinum-based chemotherapeutic regimen for
management of primary disease containing carboplatin, cisplatin, or another
organoplatinum compound; this initial treatment may have included intraperitoneal
therapy, consolidation, or extended therapy administered after surgical or
non-surgical assessment

- Patients are allowed to receive, but are not required to receive, one additional
cytotoxic regimen for management of recurrent or persistent disease according to the
following definition:

- Cytotoxic regimens include any agent that targets the genetic and/or mitotic
apparatus of dividing cells, resulting in dose-limiting toxicity to the bone
marrow and/or gastrointestinal mucosa

- Patients who have received only one prior cytotoxic regimen (platinum-based regimen
for management of primary disease) must have a platinum-free interval of less than 12
months, or have progressed during platinum-based therapy, or have persistent disease
after a platinum-based therapy

- Patients may have received prior biologic therapy, but must not have had any prior
therapy with agents which inhibit VEGF, vascular endothelial growth factor receptor
(VEGFR) or PDGF such as, bevacizumab, sorafenib, sunitinib, pazopanib, brivanib,
aflibercept cediranib, BIBF 1120, imatinib, dasatinib

- Any other prior therapy directed at the malignant tumor, including immunologic agents
(e.g. tamoxifen) must be discontinued at least three weeks prior to registration

- Patients must not be eligible for a higher priority (e.g.; Phase III), GOG protocol
for the same population if one exists

- Patients must be recovered from effects of recent surgery (28 days must elapse between
surgery and the start of treatment with sunitinib malate)

- Patents must have >= 4 weeks since prior chemotherapy or radiation (>= 6 weeks for
nitrosoureas or mitomycin C)

- Sunitinib metabolizes via liver enzyme, specifically the cytochrome P450 family 3,
subfamily A, polypeptide 4 (CYP3A4) enzyme; therefore, potential drug interaction with
the CYP3A4 enzyme can occur; eligible patients who are on the CYP3A4 inducer or
inhibitor enzyme should stop 2 weeks prior to study entry if all other eligibility has
been confirmed; the principal investigator will review the case and make all effort to
switch such agent to other medication

- Patients should be free of active infection (with the exception of uncomplicated
urinary tract infections [UTI]) requiring antibiotics

- Patients who have received one prior regimen must have a GOG performance status of 0,
1 or 2; patients who have received two prior regimens must have GOG performance status
of 0 or 1

- Absolute neutrophil count (ANC) >= 1,500/mcl

- Platelets greater than or equal 100,000/mcl

- Creatinine less than or equal to 1.5 times the upper limit of normal (ULN)

- Bilirubin less than or equal to 1.5 ULN

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal
to 2.5 times the ULN, unless subjects have liver metastasis, in which case both AST
and ALT must be less than or equal to 5 times the ULN

- Patients who have met the pre-entry requirements

- Patients must have signed an approved informed consent and authorization permitting
release of personal health information

Exclusion Criteria:

- Primary peritoneal or fallopian tube primaries are not eligible

- Patients with serious non-healing wound, ulcer, or bone fracture

- Patients with active bleeding or pathologic conditions that carry high risk of
bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major
vessels

- Patients with history or evidence upon physical examination of central nervous system
(CNS) disease, including primary brain tumor, seizures not controlled with standard
medical therapy, any brain metastases, or history of cerebrovascular accident (CVA,
stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within 6months of
the first date of treatment on this study

- Patients with clinically significant cardiovascular disease; this includes:

- Poorly controlled hypertension (systolic blood pressure of >= 140 mm Hg or
diastolic blood pressure of >= 90 mm Hg) are ineligible

- Myocardial infarction or unstable angina within 6 months prior to registration

- New York Heart Association (NYHA) grade II or greater congestive heart failure

- Cardiac arrhythmia requiring medication

- Grade II or greater peripheral vascular disease based on National Cancer
Institute Common Terminology Criteria (NCI CTC); e.g. ischemic rest pain, minor
tissue loss, and ulceration or gangrene

- Patients with QTc prolongation (> 500 msec) are excluded

- Patients who require use of therapeutic doses of Coumadin-derivative anticoagulants
such as warfarin are ineligible, although doses of up to 2 mg daily are permitted for
prophylaxis of thrombosis; low molecular weight heparin is permitted provided
patient's prothrombin time (PT) international normalized ratio (INR) is =< 1.5

- Patients with clinically significant peripheral artery disease, e.g., those with
claudication, within 6 months

- Patients with a pre-existing thyroid abnormality who are unable to maintain thyroid
function in the normal range with medication are ineligible; patients with a history
of hypothyroidism are eligible provided they are currently euthyroid

- Patients whose circumstances do not permit completion of the study or the required
follow-up

- Patients who are pregnant or nursing; to date, no fetal studies in animals or humans
have been performed; the possibility of harm to a fetus is likely; this drug
specifically inhibits VEGF, which is responsible for formation of new blood vessels
during development, and antibodies can cross the placenta; therefore, it should not be
administered to pregnant women; subjects will be apprised of the large potential risk
to a developing fetus; it is not known whether the drug is excreted in human milk;
because many drugs are excreted in human milk, this drug should not be administered to
nursing women; women of childbearing potential must agree to use contraceptive
measures during study therapy and for at least 3 months after completion of therapy; a
negative serum pregnancy test within 72 hours of starting drug is required

- Patients who have a major surgical procedure, or significant traumatic injury within
28 days prior to the first date of treatment on this study, or anticipation of need
for major surgical procedure during the course of the study; patients with placement
of vascular access device or core biopsy within 7 days prior to the first date of
treatment on this study

- Patients with other invasive malignancies, with the exception of non-melanoma skin
cancer, who had (or have) any evidence of other cancer present within the last 5 years
or whose previous cancer treatment contraindicates this protocol therapy

- Patients who have received prior therapy with this drug
We found this trial at
92
sites
100 North Academy Avenue
Danville, Pennsylvania 17822
570-271-6211
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
?
mi
from
Danville, PA
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
?
mi
from
Abington, PA
Click here to add this to my saved trials
Ames, Iowa 50010
?
mi
from
Ames, IA
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Ann Arbor, Michigan 48106
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
?
mi
from
Boise, ID
Click here to add this to my saved trials
?
mi
from
Burbank, CA
Click here to add this to my saved trials
Charlotte, North Carolina 28204
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Charlotte, North Carolina 28204
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
18101 Lorain Avenue
Cleveland, Ohio 44111
216.476.7000
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
3535 Olentangy River Rd
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Concord, California 94520
?
mi
from
Concord, CA
Click here to add this to my saved trials
Concord, North Carolina 28025
?
mi
from
Concord, NC
Click here to add this to my saved trials
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
5201 Harry Hines Blvd
Dallas, Texas 75235
(214) 590-8000
Parkland Memorial Hospital As our community's public health system, Parkland is the foundation for a...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Dearborn, Michigan 48124
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
Detroit, Michigan 48236
?
mi
from
Detroit, MI
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
600 East Blvd
Elkhart, Indiana 46515
(574) 294-2621
Elkhart General Hospital For over 100 years, the highly skilled professionals of Elkhart General Hospital...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
500 Arcade Blvd, Ste 240
Elkhart, Indiana 46514
574-389-0414
Michiana Hematology-Oncology The Advanced Center for Cancer Care in Plymouth is part of the Cancer...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
3401 Ludington St
Escanaba, Michigan 49829
(800) 432-6049
Green Bay Oncology - Escanaba We are one of a select few physician groups in...
?
mi
from
Escanaba, MI
Click here to add this to my saved trials
1 Genesys Pkwy
Grand Blanc, Michigan 48439
(810) 606-5000
Genesys Regional Medical Center Genesys Health System, a member of Ascension Health, is a group...
?
mi
from
Grand Blanc, MI
Click here to add this to my saved trials
835 S Van Buren St
Green Bay, Wisconsin 54301
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
1726 Shawano Avenue
Green Bay, Wisconsin 54303
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
835 S. Van Buren St.
Green Bay, Wisconsin 54301
(920) 884-3135
Green Bay Oncology at Saint Vincent Hospital We are one of a select few physician...
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
1726 Shawano Ave.
Green Bay, Wisconsin 54303
(920) 884-3135
Green Bay Oncology Limited at Saint Mary's Hospital We are one of a select few...
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
?
mi
from
Hartford, CT
Click here to add this to my saved trials
?
mi
from
Hazleton, PA
Click here to add this to my saved trials
121 North Elm Street
Hinsdale, Illinois 60521
?
mi
from
Hinsdale, IL
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Indianapolis, Indiana 46260
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
1721 S Stephenson Ave
Iron Mountain, Michigan 49801
(906) 776-5660
Green Bay Oncology - Iron Mountain We are one of a select few physician groups...
?
mi
from
Iron Mountain, MI
Click here to add this to my saved trials
205 NE Ave
Jackson, Michigan 49201
(517) 788-4800
Allegiance Health Allegiance Health is a community-owned and locally-governed health system in Jackson, Michigan. We...
?
mi
from
Jackson, MI
Click here to add this to my saved trials
?
mi
from
Jung-Ku,
Click here to add this to my saved trials
1521 Gull Rd
Kalamazoo, Michigan 49048
269) 226-7000
Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
3500 S. Lafountain Street
Kokomo, Indiana 46902
765-453-0702
Community Howard Regional Health Selecting quality health care services for yourself, a relative or friend...
?
mi
from
Kokomo, IN
Click here to add this to my saved trials
La Porte, Indiana 46350
?
mi
from
La Porte, IN
Click here to add this to my saved trials
1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-1000
Sparrow Hospital Sparrow has grown to become the region's largest health system, and its diverse...
?
mi
from
Lansing, MI
Click here to add this to my saved trials
Livonia, Michigan 48154
?
mi
from
Livonia, MI
Click here to add this to my saved trials
1983 Marengo St
Los Angeles, California 90033
(323) 226-2622
Los Angeles County-USC Medical Center The origins of LAC+USC Medical Center date back to 1878,...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
2300 Western Ave
Manitowoc, Wisconsin 54221
(920) 320-2011
Holy Family Memorial Hospital We are the recognized leader and the largest provider of health...
?
mi
from
Manitowoc, WI
Click here to add this to my saved trials
3100 Shore Drive
Marinette, Wisconsin 54143
715.735.4200
Bay Area Medical Center Bay Area Medical Center was created in 1985, but its history...
?
mi
from
Marinette, WI
Click here to add this to my saved trials
Mayfield Heights, Ohio 44124
?
mi
from
Mayfield Heights, OH
Click here to add this to my saved trials
9485 Mentor Ave
Mentor, Ohio 44060
(440) 205-5755
Lake University Ireland Cancer Center Lake Health is a private, not-for-profit leader in community health...
?
mi
from
Mentor, OH
Click here to add this to my saved trials
Milwaukee, Wisconsin 53215
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
5340 Holy Cross Pkwy
Mishawaka, Indiana 46545
(574) 237-1328
Michiana Hematology Oncology PC-Mishawaka Michiana Hematology Oncology's Advanced Centers for Cancer Care include the largest...
?
mi
from
Mishawaka, IN
Click here to add this to my saved trials
?
mi
from
Mishawaka, IN
Click here to add this to my saved trials
Niles, Michigan 49120
?
mi
from
Niles, MI
Click here to add this to my saved trials
?
mi
from
Oconto Falls, WI
Click here to add this to my saved trials
940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
8303 Dodge Street
Omaha, Nebraska 68114
(402) 354–4000
Nebraska Methodist Hospital Methodist Hospital is a general medical and surgical hospital in Omaha, NE....
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Orlando, Florida 32803
?
mi
from
Orlando, FL
Click here to add this to my saved trials
1915 Lake Ave
Plymouth, Indiana 46563
574-936-2585
Michiana Hematology Oncology In 1968, medical oncologist Thomas Troeger, MD had a dream to advance...
?
mi
from
Plymouth, IN
Click here to add this to my saved trials
Pontiac, Michigan 48341
?
mi
from
Pontiac, MI
Click here to add this to my saved trials
Port Huron, Michigan 48060
?
mi
from
Port Huron, MI
Click here to add this to my saved trials
Portland, Maine 04102
?
mi
from
Portland, ME
Click here to add this to my saved trials
Providence, Rhode Island 02905
?
mi
from
Providence, RI
Click here to add this to my saved trials
?
mi
from
Reno, NV
Click here to add this to my saved trials
Reno, Nevada 89502
?
mi
from
Reno, NV
Click here to add this to my saved trials
800 S Washington Ave
Saginaw, Michigan 48601
(989) 907-8000
Saint Mary's of Michigan At St. Mary's of Michigan, we continue to grow our outreach...
?
mi
from
Saginaw, MI
Click here to add this to my saved trials
3900 Hollywood Road
Saint Joseph, Michigan 49085
(269) 428-4411
Marie Yeager Cancer Center The Marie Yeager Cancer Center is located at the Lakeland Health...
?
mi
from
Saint Joseph, MI
Click here to add this to my saved trials
1234 West Napier Avenue
Saint Joseph, Michigan 49085
?
mi
from
Saint Joseph, MI
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
San Francisco, California 94115
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
615 N Michigan St
South Bend, Indiana 46601
(574) 647-1000
Memorial Hospital of South Bend Memorial Hospital of South Bend is a community-owned, not-for-profit corporation...
?
mi
from
South Bend, IN
Click here to add this to my saved trials
3975 William Richardson Dr
South Bend, Indiana 46601
(574) 204-7709
Michiana Hematology Oncology In 1968, medical oncologist Thomas Troeger, MD had a dream to advance...
?
mi
from
South Bend, IN
Click here to add this to my saved trials
211 North Eddy St.
South Bend, Indiana 46617
574-234-8161
South Bend Clinic The South Bend Clinic employs a staff of 610 at its five...
?
mi
from
South Bend, IN
Click here to add this to my saved trials
615 N Michigan Street
South Bend, Indiana 46601
(574) 647-7370
Northern Indiana Cancer Research Consortium The Northern Indiana Cancer Research Consortium (NICRC) is comprised of...
?
mi
from
South Bend, IN
Click here to add this to my saved trials
Springfield, Missouri 65804
?
mi
from
Springfield, MO
Click here to add this to my saved trials
1235 E Cherokee St
Springfield, Missouri 65804
(417) 820-2000
Mercy Hospital Springfield We're continuing a tradition of healing more than 120 years old. Mercy...
?
mi
from
Springfield, MO
Click here to add this to my saved trials
3801 South National Avenue
Springfield, Missouri 65807
(417) 269-6000
CoxHealth South Hospital U.S. News & World Report has ranked CoxHealth one of Missouri's best...
?
mi
from
Springfield, MO
Click here to add this to my saved trials
611 University Dr
State College, Pennsylvania 16801
(814) 272-7200
Geisinger Medical Group Geisinger is an integrated health services organization widely recognized for its innovative...
?
mi
from
State College, PA
Click here to add this to my saved trials
323 S. 18th Avenue
Sturgeon Bay, Wisconsin 54235
(920) 884-3135
Green Bay Oncology - Sturgeon Bay We are one of a select few physician groups...
?
mi
from
Sturgeon Bay, WI
Click here to add this to my saved trials
?
mi
from
Tulsa, OK
Click here to add this to my saved trials
Walnut Creek, California 94598
?
mi
from
Walnut Creek, CA
Click here to add this to my saved trials
West Allis, Wisconsin 53227
?
mi
from
West Allis, WI
Click here to add this to my saved trials
1668 South US 421
Westville, Indiana 46391
 219-785-3400
Michiana Hematology Oncology-PC Westville Michiana Hematology Oncology's Advanced Centers for Cancer Care include the largest...
?
mi
from
Westville, IN
Click here to add this to my saved trials
Wilkes-Barre, Pennsylvania 18711
?
mi
from
Wilkes-Barre, PA
Click here to add this to my saved trials