Carboplatin, Paclitaxel, and Bevacizumab With or Without Everolimus in Treating Patients With Metastatic Malignant Melanoma



Status:Active, not recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:8/13/2016
Start Date:April 2010

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A Randomized Phase II Trial of Carboplatin, Paclitaxel, Bevacizumab, With or Without Everolimus for Therapy of Metastatic Malignant Melanoma

This randomized phase II trial is studying how well carboplatin, paclitaxel, and bevacizumab
work when given with or without everolimus in treating patients with malignant melanoma that
has spread from where it started to other places in the body. Drugs used in chemotherapy,
such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as bevacizumab, may block the ability of tumor cells to grow and spread. Everolimus may
stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by
blocking blood flow to the tumor. It is not yet known whether combination chemotherapy given
together with bevacizumab is more effective with or without everolimus in treating patients
with metastatic melanoma.

OBJECTIVES:

Primary

- To assess whether there is sufficient promise of an impact of the addition of
everolimus to the combination of carboplatin, paclitaxel, and bevacizumab on
progression-free survival that it would be recommended for further testing in patients
with metastatic malignant melanoma.

Secondary

- To estimate the confirmed tumor response rate of each of the treatment regimens.

- To estimate the distribution of overall survival (OS) time for each of the treatment
regimens.

- To assess the impact on the safety profile of the addition of everolimus to the
combination of carboplatin, paclitaxel, and bevacizumab.

OUTLINE: This is a multicenter study. Patients are stratified according to elevated LDH
(above upper limit of normal) at baseline (yes vs no), location of metastatic disease (M1a
[skin, subcutaneous tissue, or lymph node only] vs M1b [lung] vs M1c [other visceral sites])
and prior chemotherapy for metastatic disease (yes vs no). Patients are randomized to 1 of 2
treatment arms.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15,
paclitaxel IV over 60 minutes on days 1, 8, and 15, and carboplatin IV over 30 minutes on
day 1. Courses repeat every 28 days in the absence of disease progression or unacceptable
toxicity.

ARM II: Patients receive bevacizumab, paclitaxel, and carboplatin as in Arm I. Patients also
receive everolimus orally (PO) once daily (QD) 3 times weekly. Courses repeat every 28 days
in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3-6 months for up to 5
years.

Inclusion Criteria:

- Histologic proof of stage IV malignant melanoma not amenable to surgery; (biopsy can
be of locoregional disease in setting of clinically evident stage IV disease, but
primary tumor alone will not qualify)

- At most one prior chemotherapy based regimen for metastatic melanoma (no prior
taxane-based regimens allowed); note: prior adjuvant non-taxane based chemotherapy
and/or adjuvant immunotherapy are allowed; no limit on the number of prior biologic,
immunologic or targeted therapies

- Measurable disease defined as at least one lesion whose longest diameter can be
accurately measured as >= 2.0 cm with chest x-ray, or as >= 1.0 cm with computed
tomography (CT) scan, CT component of a positron emission tomography (PET)/CT, or
magnetic resonance imaging (MRI) scan; note: disease that is measurable by physical
examination only is not eligible

- Life expectancy >= 4 months

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Absolute neutrophil count (ANC) >= 1500/mL

- Platelets (PLT) >= 100,000 x 10^9/L

- Hemoglobin (Hgb) >= 9 g/dL (patients may be transfused to meet this requirement)

- Total cholesterol =< 300 mg/dL and; (note: serum levels of cholesterol or
triglycerides found to be elevated may be lowered with anti-lipid therapy, but must
be documented to be below these levels prior to enrollment)

- Triglycerides =< 2.5 X upper limit of normal (ULN); (note: serum levels of
cholesterol or triglycerides found to be elevated may be lowered with anti-lipid
therapy, but must be documented to be below these levels prior to enrollment)

- Creatinine =< 1.5 x ULN

- Total bilirubin =< 1.5 mg/dL (exception: patients with documented Gilbert's syndrome
are allowed to participate despite elevated bilirubin)

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =<
2.5 x ULN

- Alkaline phosphatase =< 2.5 x ULN

- Urine protein:creatinine (UPC) ratio < 1.0 at screening OR

- Urine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on
dipstick urinalysis at baseline should undergo a 24 hour urine collection and must
demonstrate =< 1 g of protein in 24 hours to be eligible)

- Negative pregnancy test done =< 7 days prior to registration/randomization, for women
of childbearing potential only

- Ability to understand and the willingness to sign a written informed consent document

- Willing to return to a North Central Cancer Treatment Group (NCCTG) institution for
follow-up

- Willing to provide mandatory blood samples for research purposes

- Willing to follow a diet low in fat and cholesterol while taking everolimus

- Willing to abstain from eating grapefruit or drinking grapefruit juice for the
duration of the study

Exclusion Criteria

- Prior treatment with agents disrupting vascular endothelial growth factor (VEGF)
activity (i.e., bevacizumab, VEGF-trap, anti-VEGF receptor [R] monoclonal antibody
[Mab]) or targeting VEGFR (e.g. sunitinib, sorafenib)

- Prior treatment with an mTOR inhibitor for melanoma (sirolimus, temsirolimus,
everolimus)

- Brain metastases per MRI or CT at any time prior to registration; note: patients that
have had primary therapy for brain metastasis (i.e. surgical resection, whole brain
radiation, or stereotactic radiation therapy [SRT] even if stable) are not eligible

- Other investigational agents =< 4 weeks prior to registration/randomization

- Chemotherapy treatment =< 3 weeks prior to registration/randomization

- Any biologic, immunologic or targeted therapy =< 2 weeks prior to
registration/randomization

- Major surgical procedure, open biopsy, or significant traumatic injury =< 4 weeks
prior to registration/randomization

- Fine needle aspirations or core biopsies =< 7 days prior to
registration/randomization

- Planned/or anticipated major surgical procedure during the course of the study

- Other medical conditions including but not limited to:

- History of liver disease such as cirrhosis, chronic active hepatitis, chronic
persistent hepatitis or hepatitis B or C

- Active infection requiring parenteral antibiotics

- Poorly controlled high blood pressure (>=150 mm Hg systolic and/or 100 mmHg
diastolic) despite treatment

- New York Heart Association class II-IV congestive heart failure

- Serious cardiac arrhythmia requiring medication

- Myocardial infarction or unstable angina =< 6 months prior to
registration/randomization

- Clinically significant peripheral vascular disease

- Deep venous thrombosis or pulmonary embolus =< 1 year of
registration/randomization and/or ongoing need for full-dose oral or parenteral
anticoagulation

- Ongoing anti-platelet treatment other than low-dose aspirin (i.e., aspirin 81 mg
orally [p.o.] daily)

- Active bleeding or pathological conditions that carry high risk of bleeding
(e.g., known esophageal varices, etc.)

- Serious, non-healing wound (including wounds healing by secondary intention),
ulcer or bone fracture

- History of abdominal fistula, gastrointestinal perforation or intra-abdominal
abscess =< 6 months prior to registration/randomization

- History of central nervous system (CNS) disease (e.g., primary brain tumor,
vascular abnormalities, etc.), clinically significant stroke or transient
ischemic attack (TIA) =< 6 months prior to registration/randomization, seizures
not controlled with standard medical therapy

- Radiographically documented tumor invading major blood vessels

- History of hypertensive crisis or hypertensive encephalopathy

- Uncontrolled diabetes as defined by fasting serum glucose > 1.5 x ULN

- Severely impaired lung function as defined as spirometry and diffusing capacity
of the lung for carbon monoxide (DLCO) that is 50% of the normal predicted value
and/or 02 saturation that is 88% or less at rest on room air

- A known history of human immunodeficiency virus (HIV) seropositivity

- Any of the following as this regimen may be harmful to a developing fetus or nursing
child:

- Pregnant women

- Nursing women

- Men and women of reproductive potential who are not using effective birth
control methods must use highly effective contraception throughout the trail and
for 6 months after last study treatment

- Existence of peripheral sensory neuropathy >= grade 2

- History of other malignancy =< 5 years with the exception of basal cell or squamous
cell carcinoma of the skin, treated with local resection only, or carcinoma in situ
(e.g. of the cervix, breast, prostate, etc.)

- =< 4 weeks since last day of adjuvant radiation therapy prior to registration or =< 2
weeks since last day of palliative radiation therapy; NOTE: patients who have had >
25% of their functional bone marrow irradiated are not eligible for this trial

- Active or recent history of hemoptysis (>= 1/2 teaspoon of bright red blood per
episode) =< 30 days prior to registration

- Known hypersensitivity to any of the components of the everolimus, bevacizumab,
carboplatin, or paclitaxel

- Current use of drugs that are known to be strong inhibitors or inducers of cytochrome
P450, family 3, subfamily A, polypeptide 4 (CYP3A4); note: if these agents are
discontinued, everolimus therapy can begin >= 7 days after discontinuation of such
agent

- Positive hepatitis B antigen (HBsAg) or hepatitis C serology (HCV) tests

- Planned immunization with attenuated live vaccines =< 7 days prior to registration or
during study period; note: close contact with those who have received attenuated live
vaccines should be avoided during treatment with everolimus; examples of live
vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus
Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccines
We found this trial at
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Oklahoma City, Oklahoma 73120
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1200 S Cedar Crest Blvd
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(610) 402-8000
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115 Business loop 70 w
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100 North Academy Ave
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1 Hurley Plaza
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1221 Pleasant St
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
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Des Moines, IA
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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Des Moines, IA
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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Des Moines, IA
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300 East Locust St., Ste 350
Des Moines, Iowa 50309
(515) 244-7586
CCOP - Iowa Oncology Research Association The Iowa Oncology Research Association (IORA) was established by...
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Des Moines, IA
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411 Laurel St New Visions
Des Moines, Iowa 50314
(515) 247-3970
Medical Oncology and Hematology Associates at Mercy Cancer Center When it comes to cancer care,...
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mi
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Des Moines, IA
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411 Laurel Street
Des Moines, Iowa 50314
(515) 247-3121
Mercy Cancer Center at Mercy Medical Center - Des Moines When it comes to cancer...
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Des Moines, IA
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Des Moines, IA
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2020 Central Ave
Dodge City, Kansas 67801
(620) 227-2488
Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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Dodge City, KS
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Duluth, Minnesota 55805
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Duluth, MN
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400 E Third Street
Duluth, Minnesota 55805
(218) 786-3868
CCOP - Duluth The Duluth CCOP, established and funded by the National Cancer Institute (NCI)...
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Duluth, MN
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502 E 2nd St,
Duluth, Minnesota 55805
(218) 727-8762
Miller - Dwan Medical Center Essentia Health-Duluth, located in the Miller-Dwan building, is a 165-bed...
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Duluth, MN
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Eau Claire, WI
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Eau Claire, WI
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6401 France Ave S
Edina, Minnesota 55435
(952) 924-5000
Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
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Edina, MN
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700 West Central
El Dorado, Kansas 67042
(316) 889-0099
Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
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El Dorado, KS
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600 East Blvd
Elkhart, Indiana 46515
(574) 294-2621
Elkhart General Hospital For over 100 years, the highly skilled professionals of Elkhart General Hospital...
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Elkhart, IN
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303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
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Elkhart, IN
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500 Arcade Blvd, Ste 240
Elkhart, Indiana 46514
574-389-0414
Michiana Hematology-Oncology The Advanced Center for Cancer Care in Plymouth is part of the Cancer...
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Elkhart, IN
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41201 Schadden Rd
Elyria, Ohio 44035
(440) 324-0480
Community Cancer Center When you have cancer, you might think first of treatments
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mi
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Elyria, OH
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6282 Linton Blvd
Elyria, Ohio 44035
(561) 495-8307
Hematology Oncology Center The Center for Hematology-Oncology was established in 1995 for the purpose of...
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Elyria, OH
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