Carboplatin, Paclitaxel, and Bevacizumab With or Without Everolimus in Treating Patients With Metastatic Malignant Melanoma



Status:Active, not recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:8/13/2016
Start Date:April 2010

Use our guide to learn which trials are right for you!

A Randomized Phase II Trial of Carboplatin, Paclitaxel, Bevacizumab, With or Without Everolimus for Therapy of Metastatic Malignant Melanoma

This randomized phase II trial is studying how well carboplatin, paclitaxel, and bevacizumab
work when given with or without everolimus in treating patients with malignant melanoma that
has spread from where it started to other places in the body. Drugs used in chemotherapy,
such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as bevacizumab, may block the ability of tumor cells to grow and spread. Everolimus may
stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by
blocking blood flow to the tumor. It is not yet known whether combination chemotherapy given
together with bevacizumab is more effective with or without everolimus in treating patients
with metastatic melanoma.

OBJECTIVES:

Primary

- To assess whether there is sufficient promise of an impact of the addition of
everolimus to the combination of carboplatin, paclitaxel, and bevacizumab on
progression-free survival that it would be recommended for further testing in patients
with metastatic malignant melanoma.

Secondary

- To estimate the confirmed tumor response rate of each of the treatment regimens.

- To estimate the distribution of overall survival (OS) time for each of the treatment
regimens.

- To assess the impact on the safety profile of the addition of everolimus to the
combination of carboplatin, paclitaxel, and bevacizumab.

OUTLINE: This is a multicenter study. Patients are stratified according to elevated LDH
(above upper limit of normal) at baseline (yes vs no), location of metastatic disease (M1a
[skin, subcutaneous tissue, or lymph node only] vs M1b [lung] vs M1c [other visceral sites])
and prior chemotherapy for metastatic disease (yes vs no). Patients are randomized to 1 of 2
treatment arms.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15,
paclitaxel IV over 60 minutes on days 1, 8, and 15, and carboplatin IV over 30 minutes on
day 1. Courses repeat every 28 days in the absence of disease progression or unacceptable
toxicity.

ARM II: Patients receive bevacizumab, paclitaxel, and carboplatin as in Arm I. Patients also
receive everolimus orally (PO) once daily (QD) 3 times weekly. Courses repeat every 28 days
in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3-6 months for up to 5
years.

Inclusion Criteria:

- Histologic proof of stage IV malignant melanoma not amenable to surgery; (biopsy can
be of locoregional disease in setting of clinically evident stage IV disease, but
primary tumor alone will not qualify)

- At most one prior chemotherapy based regimen for metastatic melanoma (no prior
taxane-based regimens allowed); note: prior adjuvant non-taxane based chemotherapy
and/or adjuvant immunotherapy are allowed; no limit on the number of prior biologic,
immunologic or targeted therapies

- Measurable disease defined as at least one lesion whose longest diameter can be
accurately measured as >= 2.0 cm with chest x-ray, or as >= 1.0 cm with computed
tomography (CT) scan, CT component of a positron emission tomography (PET)/CT, or
magnetic resonance imaging (MRI) scan; note: disease that is measurable by physical
examination only is not eligible

- Life expectancy >= 4 months

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Absolute neutrophil count (ANC) >= 1500/mL

- Platelets (PLT) >= 100,000 x 10^9/L

- Hemoglobin (Hgb) >= 9 g/dL (patients may be transfused to meet this requirement)

- Total cholesterol =< 300 mg/dL and; (note: serum levels of cholesterol or
triglycerides found to be elevated may be lowered with anti-lipid therapy, but must
be documented to be below these levels prior to enrollment)

- Triglycerides =< 2.5 X upper limit of normal (ULN); (note: serum levels of
cholesterol or triglycerides found to be elevated may be lowered with anti-lipid
therapy, but must be documented to be below these levels prior to enrollment)

- Creatinine =< 1.5 x ULN

- Total bilirubin =< 1.5 mg/dL (exception: patients with documented Gilbert's syndrome
are allowed to participate despite elevated bilirubin)

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =<
2.5 x ULN

- Alkaline phosphatase =< 2.5 x ULN

- Urine protein:creatinine (UPC) ratio < 1.0 at screening OR

- Urine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on
dipstick urinalysis at baseline should undergo a 24 hour urine collection and must
demonstrate =< 1 g of protein in 24 hours to be eligible)

- Negative pregnancy test done =< 7 days prior to registration/randomization, for women
of childbearing potential only

- Ability to understand and the willingness to sign a written informed consent document

- Willing to return to a North Central Cancer Treatment Group (NCCTG) institution for
follow-up

- Willing to provide mandatory blood samples for research purposes

- Willing to follow a diet low in fat and cholesterol while taking everolimus

- Willing to abstain from eating grapefruit or drinking grapefruit juice for the
duration of the study

Exclusion Criteria

- Prior treatment with agents disrupting vascular endothelial growth factor (VEGF)
activity (i.e., bevacizumab, VEGF-trap, anti-VEGF receptor [R] monoclonal antibody
[Mab]) or targeting VEGFR (e.g. sunitinib, sorafenib)

- Prior treatment with an mTOR inhibitor for melanoma (sirolimus, temsirolimus,
everolimus)

- Brain metastases per MRI or CT at any time prior to registration; note: patients that
have had primary therapy for brain metastasis (i.e. surgical resection, whole brain
radiation, or stereotactic radiation therapy [SRT] even if stable) are not eligible

- Other investigational agents =< 4 weeks prior to registration/randomization

- Chemotherapy treatment =< 3 weeks prior to registration/randomization

- Any biologic, immunologic or targeted therapy =< 2 weeks prior to
registration/randomization

- Major surgical procedure, open biopsy, or significant traumatic injury =< 4 weeks
prior to registration/randomization

- Fine needle aspirations or core biopsies =< 7 days prior to
registration/randomization

- Planned/or anticipated major surgical procedure during the course of the study

- Other medical conditions including but not limited to:

- History of liver disease such as cirrhosis, chronic active hepatitis, chronic
persistent hepatitis or hepatitis B or C

- Active infection requiring parenteral antibiotics

- Poorly controlled high blood pressure (>=150 mm Hg systolic and/or 100 mmHg
diastolic) despite treatment

- New York Heart Association class II-IV congestive heart failure

- Serious cardiac arrhythmia requiring medication

- Myocardial infarction or unstable angina =< 6 months prior to
registration/randomization

- Clinically significant peripheral vascular disease

- Deep venous thrombosis or pulmonary embolus =< 1 year of
registration/randomization and/or ongoing need for full-dose oral or parenteral
anticoagulation

- Ongoing anti-platelet treatment other than low-dose aspirin (i.e., aspirin 81 mg
orally [p.o.] daily)

- Active bleeding or pathological conditions that carry high risk of bleeding
(e.g., known esophageal varices, etc.)

- Serious, non-healing wound (including wounds healing by secondary intention),
ulcer or bone fracture

- History of abdominal fistula, gastrointestinal perforation or intra-abdominal
abscess =< 6 months prior to registration/randomization

- History of central nervous system (CNS) disease (e.g., primary brain tumor,
vascular abnormalities, etc.), clinically significant stroke or transient
ischemic attack (TIA) =< 6 months prior to registration/randomization, seizures
not controlled with standard medical therapy

- Radiographically documented tumor invading major blood vessels

- History of hypertensive crisis or hypertensive encephalopathy

- Uncontrolled diabetes as defined by fasting serum glucose > 1.5 x ULN

- Severely impaired lung function as defined as spirometry and diffusing capacity
of the lung for carbon monoxide (DLCO) that is 50% of the normal predicted value
and/or 02 saturation that is 88% or less at rest on room air

- A known history of human immunodeficiency virus (HIV) seropositivity

- Any of the following as this regimen may be harmful to a developing fetus or nursing
child:

- Pregnant women

- Nursing women

- Men and women of reproductive potential who are not using effective birth
control methods must use highly effective contraception throughout the trail and
for 6 months after last study treatment

- Existence of peripheral sensory neuropathy >= grade 2

- History of other malignancy =< 5 years with the exception of basal cell or squamous
cell carcinoma of the skin, treated with local resection only, or carcinoma in situ
(e.g. of the cervix, breast, prostate, etc.)

- =< 4 weeks since last day of adjuvant radiation therapy prior to registration or =< 2
weeks since last day of palliative radiation therapy; NOTE: patients who have had >
25% of their functional bone marrow irradiated are not eligible for this trial

- Active or recent history of hemoptysis (>= 1/2 teaspoon of bright red blood per
episode) =< 30 days prior to registration

- Known hypersensitivity to any of the components of the everolimus, bevacizumab,
carboplatin, or paclitaxel

- Current use of drugs that are known to be strong inhibitors or inducers of cytochrome
P450, family 3, subfamily A, polypeptide 4 (CYP3A4); note: if these agents are
discontinued, everolimus therapy can begin >= 7 days after discontinuation of such
agent

- Positive hepatitis B antigen (HBsAg) or hepatitis C serology (HCV) tests

- Planned immunization with attenuated live vaccines =< 7 days prior to registration or
during study period; note: close contact with those who have received attenuated live
vaccines should be avoided during treatment with everolimus; examples of live
vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus
Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccines
We found this trial at
313
sites
1740 E Broad St
Hazleton, Pennsylvania 18201
(570) 459-2901
Geisinger Hazleton Cancer Center At the Geisinger Cancer Institute, we strive to better understand cancer...
?
mi
from
Hazleton, PA
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Lehigh Valley Hospital provides a...
?
mi
from
Allentown, PA
Click here to add this to my saved trials
115 Business loop 70 w
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
?
mi
from
Columbia, MO
Click here to add this to my saved trials
3535 Olentangy River Road
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Cancer Care Serving central Ohio since 1892, Riverside Methodist is consistently ranked...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
100 North Academy Ave
Danville, Pennsylvania 17822
570-271-6211
Geisinger Cancer Institute at Geisinger Health Since 1915, Geisinger Medical Center has been known as...
?
mi
from
Danville, PA
Click here to add this to my saved trials
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
?
mi
from
Denver, CO
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 492-5764
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Holy Cross Hospital's Michael...
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
1920 Libal Street
Green Bay, Wisconsin 54307
(920) 433-8889
St. Vincent Hospital Regional Cancer Center Our group of 19 oncologists, including the region's only...
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
900 West Faris Road
Greenville, South Carolina 29605
(864) 679-3900
Cancer Centers of the Carolinas - Faris Road Cancer Centers of the Carolinas is now...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
3 Butternut Drive, Suite B
Greenville, South Carolina 29605
(864) 241-7272
Cancer Centers of the Carolinas - Grove Commons Cancer Centers of the Carolinas is now...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
33 Villa Road, Suite 400
Greenville, South Carolina 29615
(864) 404-2045
CCOP - Greenville Cancer care in the last decade has made many advances. Most of...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
701 Grove Rd # 1
Greenville, South Carolina 29605
(864) 455-7000
Greenville Hospital Cancer Center Greenville Health System (GHS) is a public not-for-profit academic healthcare delivery...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
340 Medical Pkwy
Greer, South Carolina 29650
(864) 334-4900
Cancer Centers of the Carolinas - Greer Medical Oncology Cancer Centers of the Carolinas is...
?
mi
from
Greer, SC
Click here to add this to my saved trials
19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
?
mi
from
Grosse Pointe Woods, MI
Click here to add this to my saved trials
200 Hawkins Drive
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
1240 S Old Dixie Hwy
Jupiter, Florida 33458
(561) 263-4400
Ella Milbank Foshay Cancer Center at Jupiter Medical Center The Foshay Cancer Center is one...
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
1900 South Avenue
La Crosse, Wisconsin 54601
(608) 782-7300
Gundersen Lutheran Center for Cancer and Blood Gundersen Health System is where caring meets excellence...
?
mi
from
La Crosse, WI
Click here to add this to my saved trials
1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
4300 Alton Road
Miami Beach, Florida 33140
(305) 674-2625
CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
?
mi
from
Miami Beach, FL
Click here to add this to my saved trials
131 Lila Doyle Drive
Seneca, South Carolina 29672
(864) 888-3717
Cancer Centers of the Carolinas - Seneca Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Seneca, SC
Click here to add this to my saved trials
120 Dillon Dr
Spartanburg, South Carolina 29307
(864) 699-5700
Cancer Centers of the Carolinas - Spartanburg Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Spartanburg, SC
Click here to add this to my saved trials
825 N Emporia Ave
Wichita, Kansas 67214
(316) 261-3200
Via Christi Cancer Center at Via Christi Regional Medical Center Via Christi Health's rich history...
?
mi
from
Wichita, KS
Click here to add this to my saved trials
777 Kimole Ln
Adrian, Michigan 49221
517-265-0900
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
?
mi
from
Adrian, MI
Click here to add this to my saved trials
Ames, Iowa 50010
McFarland Clinic, PC It has been over 65 years since the founders of McFarland Clinic...
?
mi
from
Ames, IA
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-4673
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
364 White Oak St
Asheboro, North Carolina 27203
(336) 625-5151
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
?
mi
from
Asheboro, NC
Click here to add this to my saved trials
700 Potomac St
Aurora, Colorado 80012
(303) 363-7200
Aurora Presbyterian Hospital At The Medical Center of Aurora and Centennial Medical Plaza, we treat...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Aurora, Illinois 60507
?
mi
from
Aurora, IL
Click here to add this to my saved trials
300 North Ave
Battle Creek, Michigan 49017
(269) 245-8000
Battle Creek Health System Cancer Care Center As a proud member of the Battle Creek...
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
1233 34th St NW
Bemidji, Minnesota 56601
(218) 333-5000
MeritCare Bemidji Sanford Health is an integrated health system headquartered in the Dakotas and is...
?
mi
from
Bemidji, MN
Click here to add this to my saved trials
?
mi
from
Bettendorf, IA
Click here to add this to my saved trials
605 Oak St
Big Rapids, Michigan 49307
(231) 796-8691
Mecosta County Medical Center Spectrum Health is a not-for-profit system of care dedicated to improving...
?
mi
from
Big Rapids, MI
Click here to add this to my saved trials
Billings, Montana 59101
?
mi
from
Billings, MT
Click here to add this to my saved trials
Billings, Montana 59107
?
mi
from
Billings, MT
Click here to add this to my saved trials
2900 12th Ave N Ste 160W
Billings, Montana 59101
(406) 238-6290
Hematology-Oncology Centers of the Northern Rockies - Billings The physicians and staff of Hematology-Oncology Centers...
?
mi
from
Billings, MT
Click here to add this to my saved trials
1101 N 27th St # 201
Billings, Montana 59101
(406) 237-3585
St. Vincent Healthcare Cancer Care Services The Sisters of Charity of Leavenworth, Kansas, founded St....
?
mi
from
Billings, MT
Click here to add this to my saved trials
720 E Rosser Ave
Bismarck, North Dakota 58501
(701) 323-6741
Medcenter One Hospital Cancer Care Center Sanford Health is an integrated health system headquartered in...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 East Broadway
Bismarck, North Dakota 58501
701.530.7000
St. Alexius Medical Center Cancer Center Throughout the healing continuum we are dedicated to our...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
2200 E Washington St,
Bloomington, Illinois 61701
(309) 662-3311
St. Joseph Medical Center Located in Bloomington, Illinois, OSF St. Joseph Medical Center is a...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1055 N Curtis Rd
Boise, Idaho 83706
(208) 367-2121
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Saint Alphonsus Health System...
?
mi
from
Boise, ID
Click here to add this to my saved trials
72 East Concord St.
Boston, Massachusetts 02118
617-638-4173
Boston University Cancer Research Center
?
mi
from
Boston, MA
Click here to add this to my saved trials
1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
?
mi
from
Boulder, CO
Click here to add this to my saved trials
960 W. Wooster
Bowling Green, Ohio 43402
419-352-9498
Wood County Oncology Center The Cancer Care Center at Wood County Hospital opened March 2014,...
?
mi
from
Bowling Green, OH
Click here to add this to my saved trials
931 Highland Blvd
Bozeman, Montana 59715
(406) 585-5070
Bozeman Deaconess Cancer Center Bozeman Deaconess Cancer Center provides the latest cancer technologies and treatment...
?
mi
from
Bozeman, MT
Click here to add this to my saved trials
Brainerd, Minnesota 56401
?
mi
from
Brainerd, MN
Click here to add this to my saved trials
201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
?
mi
from
Burnsville, MN
Click here to add this to my saved trials
400 S Clark St
Butte, Montana 59701
(406) 723-2616
St. James Healthcare Cancer Care The St. James Cancer Center is an integrated cancer treatment...
?
mi
from
Butte, MT
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
309-647-5240
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Canton, IL
Click here to add this to my saved trials
789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
(573) 519-4725
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
701 10th St SE
Cedar Rapids, Iowa 52403
(319) 365-4673
Mercy Regional Cancer Center at Mercy Medical Center Hall-Perrine Cancer Center is a part of...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
525 10th St SE
Cedar Rapids, Iowa 52403
(319) 363-8303
Cedar Rapids Oncology Associates Oncology Associates at Mercy Medical Center in Cedar Rapids (also known...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
?
mi
from
Chanute, KS
Click here to add this to my saved trials
272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
?
mi
from
Chillicothe, OH
Click here to add this to my saved trials
12495 University Ave
Clive, Iowa 50325
(515) 358-9700
Mercy Cancer Center - West Lakes When it comes to cancer care, there
?
mi
from
Clive, IA
Click here to add this to my saved trials
?
mi
from
Clive, IA
Click here to add this to my saved trials
2222 N. Nevada Avenue
Colorado Springs, Colorado 80907
(719) 776-5000
Penrose Cancer Center at Penrose Hospital Through a full range of clinical trials, genetic counseling,...
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
?
mi
from
Columbus, GA
Click here to add this to my saved trials
111 S Grant Avenue
Columbus, Ohio 43215
(614) 566-4321
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Columbus, Ohio 43228
?
mi
from
Columbus, OH
Click here to add this to my saved trials
1335 Dublin Road, Suite 124A
Columbus, Ohio 43215
(614) 488-2118
CCOP - Columbus As one of the original 20 CCOPs, the Columbus Community Clinical Oncology...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
793 West State Street
Columbus, Ohio 43222
614-234-5000
Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
11850 Blackfoot St. NW Suite 130
Coon Rapids, Minnesota 55433
763-236-0808
Mercy and Unity Cancer Center at Mercy Hospital The Virginia Piper Cancer Institute - Mercy...
?
mi
from
Coon Rapids, MN
Click here to add this to my saved trials
142 S Main St
Danville, Virginia 24541
(434) 799-2100
Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
?
mi
from
Danville, VA
Click here to add this to my saved trials
1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Dayton, Ohio 45406
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Dayton, Ohio 45420
?
mi
from
Dayton, OH
Click here to add this to my saved trials
405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
9000 North Main Street
Dayton, Ohio 45415
(937) 734-5800
Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
?
mi
from
Delaware, OH
Click here to add this to my saved trials
2525 S Downing St
Denver, Colorado 80210
(303) 778-1955
Porter Adventist Hospital Founded in 1930, Porter Adventist Hospital has provided people throughout Denver and...
?
mi
from
Denver, CO
Click here to add this to my saved trials
4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
?
mi
from
Denver, CO
Click here to add this to my saved trials
11600 W 2nd Pl
Denver, Colorado 80204
(720) 321-0000
St. Anthony Central Hospital The St. Anthony Medical Campus in Lakewood combines our heritage of...
?
mi
from
Denver, CO
Click here to add this to my saved trials
Denver, Colorado 80218
?
mi
from
Denver, CO
Click here to add this to my saved trials
1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
300 East Locust St., Ste 350
Des Moines, Iowa 50309
(515) 244-7586
CCOP - Iowa Oncology Research Association The Iowa Oncology Research Association (IORA) was established by...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
1221 Pleasant St
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
1221 Pleasant St
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
411 Laurel St New Visions
Des Moines, Iowa 50314
(515) 247-3970
Medical Oncology and Hematology Associates at Mercy Cancer Center When it comes to cancer care,...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
411 Laurel Street
Des Moines, Iowa 50314
(515) 247-3121
Mercy Cancer Center at Mercy Medical Center - Des Moines When it comes to cancer...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
2020 Central Ave
Dodge City, Kansas 67801
(620) 227-2488
Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
?
mi
from
Dodge City, KS
Click here to add this to my saved trials
Duluth, Minnesota 55805
?
mi
from
Duluth, MN
Click here to add this to my saved trials
400 E Third Street
Duluth, Minnesota 55805
(218) 786-3868
CCOP - Duluth The Duluth CCOP, established and funded by the National Cancer Institute (NCI)...
?
mi
from
Duluth, MN
Click here to add this to my saved trials
502 E 2nd St,
Duluth, Minnesota 55805
(218) 727-8762
Miller - Dwan Medical Center Essentia Health-Duluth, located in the Miller-Dwan building, is a 165-bed...
?
mi
from
Duluth, MN
Click here to add this to my saved trials
?
mi
from
Eau Claire, WI
Click here to add this to my saved trials
?
mi
from
Eau Claire, WI
Click here to add this to my saved trials
6401 France Ave S
Edina, Minnesota 55435
(952) 924-5000
Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
?
mi
from
Edina, MN
Click here to add this to my saved trials
700 West Central
El Dorado, Kansas 67042
(316) 889-0099
Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
?
mi
from
El Dorado, KS
Click here to add this to my saved trials
303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
600 East Blvd
Elkhart, Indiana 46515
(574) 294-2621
Elkhart General Hospital For over 100 years, the highly skilled professionals of Elkhart General Hospital...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
500 Arcade Blvd, Ste 240
Elkhart, Indiana 46514
574-389-0414
Michiana Hematology-Oncology The Advanced Center for Cancer Care in Plymouth is part of the Cancer...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
41201 Schadden Rd
Elyria, Ohio 44035
(440) 324-0480
Community Cancer Center When you have cancer, you might think first of treatments
?
mi
from
Elyria, OH
Click here to add this to my saved trials
6282 Linton Blvd
Elyria, Ohio 44035
(561) 495-8307
Hematology Oncology Center The Center for Hematology-Oncology was established in 1995 for the purpose of...
?
mi
from
Elyria, OH
Click here to add this to my saved trials