An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene



Status:Completed
Conditions:Lung Cancer, Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:September 2009
End Date:January 2016

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Phase 3, Randomized, Open-Label Study Of The Efficacy And Safety Of PF-02341066 Versus Standard Of Care Chemotherapy (Pemetrexed Or Docetaxel) In Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (ALK) Gene Locus

This is a Phase 3 trial comparing the safety and anti-tumor activity of PF-02341066 versus
pemetrexed or docetaxel in patients with advanced non-small cell lung cancer with specific
gene profile involving the ALK gene after failure of one previous chemotherapy regimen that
included one platinum drug.


Inclusion Criteria:

- histologically or cytologically proven diagnosis of non-small cell lung cancer

- positive for the ALK fusion gene (test provided by a central laboratory)

- must have had disease progression after only one prior chemotherapy and that regimen
but must have included one platinum drug

- tumors must be measurable

Exclusion Criteria:

- prior treatment with PF-02341066

- current treatment in another clinical trial
We found this trial at
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Boston, Massachusetts 02215
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Boston, Massachusetts 02115
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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3700 Johnson Street
Hollywood, Florida 33021
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701 Ilalo Street Suite 600
Honolulu, Hawaii 96813
808-586-3010
Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
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550 University Boulevard
Indianapolis, Indiana 46202
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Los Angeles, California 90095
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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825 Eastlake Ave E
Seattle, Washington 98109
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12902 USF Magnolia Dr
Tampa, Florida 33612
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H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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Atlanta, Georgia 30322
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550 Peachtree St NE
Atlanta, Georgia 30308
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Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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1364 Clifton Rd NE
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Boston, Massachusetts 02114
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Boston, Massachusetts 02114
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Boston, Massachusetts 02115
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450 Brookline Ave
Boston, Massachusetts 2215
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Camperdown, New South Wales 2050
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Chapel Hill, North Carolina 27599
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1653 W. Congress Parkway
Chicago, Illinois 60612
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5841 S Maryland Ave
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2650 Kenny Road
Columbus, Ohio 43221
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Creve Coeur, Missouri 63141
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Decatur, Georgia 30033
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Denver, Colorado 80205
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Detroit, Michigan 48201
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Dickson, Tennessee 37055
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East Providence, Rhode Island 02914
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East Providence, Rhode Island 02915
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Farmington Hills, Michigan 48334
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Franklin, Tennessee 37067
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Harvey, Illinois 60426
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1 Ingalls Dr
Harvey, Illinois 60426
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Hermitage, Tennessee 37076
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Honolulu, Hawaii 96817
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Indianapolis, Indiana 46202
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Indianapolis, Indiana 46290
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535 Barnhill Dr
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Indiana University Melvin and Bren Simon Cancer Center At the IU Simon Cancer Center, more...
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La Jolla, California 92037
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Lake Success, New York 11042
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1 Medical Center Dr
Lebanon, New Hampshire 03756
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3322 West End Avenue
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250 25th Ave N, Ste 100
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333 Cedar Street
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630 W 168th St
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101 The City Drive South
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Palo Alto, California 94305
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Pembroke Pines, Florida 33028
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Philadelphia, Pennsylvania 19111
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Pittsburgh, Pennsylvania 15232
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Sacramento, California 95817
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2315 Stockton Blvd.
Sacramento, California 95817
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San Diego, California 92103
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Sandy Springs, Georgia 30342
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