Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections



Status:Recruiting
Conditions:Infectious Disease, Pulmonary
Therapuetic Areas:Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:Any - 21
Updated:2/8/2019
Start Date:October 30, 2018
End Date:December 31, 2022
Contact:PFN Central Coordinator
Email:PFNClinical@duke.edu
Phone:919-668-4847

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This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes
for children at high-risk for pulmonary invasive mold infection (PIMI).


Inclusion Criteria:

- Males or females age > 120 days and < 22 years at any participating site

- Have at least one of the following conditions associated with a known high incidence
of IMI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, or
hematologic malignancy

- New (last 96 hours) radiographic evidence showing at least one pulmonary nodule ≥ 1 cm
in diameter

- Prolonged neutropenia (absolute neutrophil count < 500 cells/µl for a period of ≥ 5
consecutive days) in 30 days prior to qualifying chest MRI or CT scan date OR
currently receiving systemic therapy for acute or chronic graft-versus-host disease
(GVHD) on the date of the qualifying chest MRI or CT scan

- Subject consent or parental/guardian permission (informed consent) and if appropriate,
child assent

Exclusion Criteria:

- Weight <3 kg, so as to not exceed 3 ml/kg in a single blood draw

- Previous inclusion in this study
We found this trial at
11
sites
225 E Chicago Ave
Chicago, Illinois 60611
(312) 227-4000
Ann & Robert H. Lurie Children's Hospital of Chicago Ann & Robert H. Lurie Children
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Chicago, IL
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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Cincinnati, OH
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Philadelphia, PA
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from
Chicago, IL
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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Houston, Texas 77030
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Houston, TX
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340 W 10th St #6200
Indianapolis, Indiana 46202
(317) 274-3772
Indiana University School of Medicine With more than 2,000 students in 2013, the Indiana University...
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Indianapolis, IN
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Kansas City, Missouri 64108
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Kansas City, MO
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8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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from
Milwaukee, WI
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from
Nashville, TN
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