Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Status: | Recruiting |
---|---|
Conditions: | Infectious Disease, Pulmonary |
Therapuetic Areas: | Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases |
Healthy: | No |
Age Range: | Any - 21 |
Updated: | 2/8/2019 |
Start Date: | October 30, 2018 |
End Date: | December 31, 2022 |
Contact: | PFN Central Coordinator |
Email: | PFNClinical@duke.edu |
Phone: | 919-668-4847 |
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes
for children at high-risk for pulmonary invasive mold infection (PIMI).
for children at high-risk for pulmonary invasive mold infection (PIMI).
Inclusion Criteria:
- Males or females age > 120 days and < 22 years at any participating site
- Have at least one of the following conditions associated with a known high incidence
of IMI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, or
hematologic malignancy
- New (last 96 hours) radiographic evidence showing at least one pulmonary nodule ≥ 1 cm
in diameter
- Prolonged neutropenia (absolute neutrophil count < 500 cells/µl for a period of ≥ 5
consecutive days) in 30 days prior to qualifying chest MRI or CT scan date OR
currently receiving systemic therapy for acute or chronic graft-versus-host disease
(GVHD) on the date of the qualifying chest MRI or CT scan
- Subject consent or parental/guardian permission (informed consent) and if appropriate,
child assent
Exclusion Criteria:
- Weight <3 kg, so as to not exceed 3 ml/kg in a single blood draw
- Previous inclusion in this study
We found this trial at
11
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Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
Cincinnati, Ohio 45229
1-513-636-4200
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Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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225 E Chicago Ave
Chicago, Illinois 60611
Chicago, Illinois 60611
(312) 227-4000
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Ann & Robert H. Lurie Children's Hospital of Chicago Ann & Robert H. Lurie Children
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Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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340 W 10th St #6200
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
(317) 274-3772
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Indiana University School of Medicine With more than 2,000 students in 2013, the Indiana University...
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Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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