Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Status: | Recruiting |
---|---|
Conditions: | Breast Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 12/23/2018 |
Start Date: | July 16, 2018 |
End Date: | July 15, 2027 |
Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive Breast Cancer
This randomized research trial studies how well serum tumor marker directed disease
monitoring works in monitoring patients with hormone receptor positive Her2 negative breast
cancer that has spread to other places in the body. Using markers to prompt when scans should
be ordered may be as good as the usual approach to monitoring disease.
monitoring works in monitoring patients with hormone receptor positive Her2 negative breast
cancer that has spread to other places in the body. Using markers to prompt when scans should
be ordered may be as good as the usual approach to monitoring disease.
PRIMARY OBJECTIVES:
I. To assess whether patients with HER-2 negative, hormone receptor positive, metastatic
breast cancer who are monitored with serum tumor marker directed disease monitoring (STMDDM)
have non-inferior overall survival compared to patients monitored with usual care.
SECONDARY OBJECTIVES:
I. To compare cumulative direct healthcare costs through 48 weeks among patients monitored
with STMDDM versus those monitored with usual care in this patient population.
II. To assess whether the patient-reported outcomes (PROs) of anxiety and quality of life
(QOL) are different among patients who are monitored with STMDDM compared with patients who
are monitored with usual care in this patient population.
TERTIARY OBJECTIVES:
I. To assess modality and frequency of disease monitoring testing in the usual care cohort.
II. To assess the association of PROs and patient preferences for disease monitoring testing.
III. To evaluate predictors of physician preferences for disease monitoring testing.
OUTLINE: Patients are randomized into 1 of 2 arms.
ARM I: Patients undergo imaging studies at a minimum frequency of every 12 weeks and continue
with usual care disease monitoring for up to 312 weeks in the absence of disease progression.
ARM II: Patients undergo disease specific serum tumor marker (STM) evaluation every 6 weeks.
Patients with elevated STM, undergo imaging evaluation. Patients continue with STMDDM for up
to 312 weeks in the absence of disease progression.
I. To assess whether patients with HER-2 negative, hormone receptor positive, metastatic
breast cancer who are monitored with serum tumor marker directed disease monitoring (STMDDM)
have non-inferior overall survival compared to patients monitored with usual care.
SECONDARY OBJECTIVES:
I. To compare cumulative direct healthcare costs through 48 weeks among patients monitored
with STMDDM versus those monitored with usual care in this patient population.
II. To assess whether the patient-reported outcomes (PROs) of anxiety and quality of life
(QOL) are different among patients who are monitored with STMDDM compared with patients who
are monitored with usual care in this patient population.
TERTIARY OBJECTIVES:
I. To assess modality and frequency of disease monitoring testing in the usual care cohort.
II. To assess the association of PROs and patient preferences for disease monitoring testing.
III. To evaluate predictors of physician preferences for disease monitoring testing.
OUTLINE: Patients are randomized into 1 of 2 arms.
ARM I: Patients undergo imaging studies at a minimum frequency of every 12 weeks and continue
with usual care disease monitoring for up to 312 weeks in the absence of disease progression.
ARM II: Patients undergo disease specific serum tumor marker (STM) evaluation every 6 weeks.
Patients with elevated STM, undergo imaging evaluation. Patients continue with STMDDM for up
to 312 weeks in the absence of disease progression.
Inclusion Criteria:
- STEP 1 REGISTRATION
- Patients must have a diagnosis of hormone receptor positive (estrogen receptor
positive [ER+] and/or progesterone receptor positive [PR+]), HER-2 negative,
metastatic (M1) breast cancer and must be receiving or plan to receive first-line
systemic treatment for metastatic disease
- NOTE: Participants are eligible if they have either de-novo metastatic breast
cancer and/or recurrent breast cancer from an earlier stage that is now
metastatic
- Patients must be registered to step 1 between 14 days prior to and 28 days after start
of first-line systemic treatment for metastatic disease
- Patients must have been tested for all of the following breast cancer specific STMs
after diagnosis of metastatic disease and within +/-14 days of initiation of
first-line systemic treatment for metastatic disease:
- CA 15-3
- CA 27.29
- CEA
- At least one of these STMs must have been >= 2 x the institutional upper limit of
normal at this time
- Patients must have systemic radiographic imaging prior to initiation of systemic
therapy for treatment of metastatic breast cancer and prior to step 1 registration
with either:
- A computed tomography (CT) scan of the chest and abdomen with or without CT
pelvis, and with or without bone scan or
- A positron emission tomography (PET) scan with or without CT
- Note: the treating physician can order additional imaging tests at any point
prior to randomization at their discretion
- Patients must be willing to obtain disease monitoring (imaging and/or serum tumor
markers) at their current center for the duration of the study intervention (312 weeks
after step 2 randomization)
- Patients with known cirrhosis, untreated B12 deficiency, thalassemia, or sickle cell
anemia are not eligible as these could cause falsely elevated STM levels
- Patients with known brain metastases are not eligible as they may require regular
radiographic monitoring to assess treatment response
- Patients must not be currently enrolled or plan to participate in a first-line
treatment trial for metastatic breast cancer with a defined monitoring schedule
- Patients who are able to complete questionnaires in English or Spanish must
participate in patient-reported outcome (PRO) assessments
- Patients must not be pregnant due to the potential harm to the fetus from radiation
exposure from radiographic imaging
- Except for breast cancer (and previous history of breast cancer), no other prior
malignancy is allowed except for adequately treated basal (or squamous cell) skin
cancer, in situ cervical cancer or other cancer for which the patient has been disease
free for five years
- Patients must not have received prior systemic therapy for metastatic breast cancer,
except for their current treatment regimen initiated no more than 28 days prior to
registration
- Patients must have decision making capacity and be able to provide informed consent
- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent in accordance with institutional and federal
guidelines; use of legally-authorized representative is not permissible for this study
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
treating institution's identity is provided in order to ensure that the current
(within 365 days) date of institutional review board approval for this study has been
entered in the system
- STEP 2 RANDOMIZATION
- Patients must be tested for all of the following breast cancer specific STMs between
56 and 112 days after initiation of first-line systemic therapy for metastatic
disease:
- CA 15-3
- CA 27.29
- CEA
- At least one of the STMs that was previously elevated must have decreased from the
assessment at step 1 by >= 25% at this time
- Patients must not have known progression since registration to step 1
- Patients must be registered to step 2 randomization between 56 days and 112 days after
the initiation of first-line systemic therapy for metastatic disease; patients must
have been eligible for step 1 in order to be eligible for step 2 randomization
- Baseline questionnaires must be completed within 28 days prior to step 2
randomization; (Note: Those patients who cannot complete the PRO questionnaires in
English or Spanish can be registered to step 2 without contributing to PRO research)
We found this trial at
241
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Principal Investigator: Timothy D. Moore
Phone: 614-566-4475
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
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111 S Grant Ave
Columbus, Ohio 43215
Columbus, Ohio 43215
(614) 566-9000
![Grant Medical Center](/wp-content/uploads/logos/grant-medical-center.jpg)
Principal Investigator: Timothy D. Moore
Phone: 614-566-4475
Grant Medical Center Founded in 1900 in Columbus' downtown, Grant has grown into one of...
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3100 Plaza Properties Blvd
Columbus, Ohio 43219
Columbus, Ohio 43219
(614) 383-6000
![The Mark H. Zangmeister Center](/wp-content/uploads/logos/the-mark-h-zangmeister-center.jpg)
Principal Investigator: Timothy D. Moore
Phone: 614-488-2118
The Mark H. Zangmeister Center At The Zangmeister Center, we appreciate that our patients have...
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Columbus, Ohio 43222
Principal Investigator: Timothy D. Moore
Phone: 614-234-5433
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5100 W Broad St
Columbus, Ohio 43228
Columbus, Ohio 43228
(614) 544-1000
![Doctors Hospital](/wp-content/uploads/logos/doctors-hospital.jpg)
Principal Investigator: Timothy D. Moore
Phone: 614-566-3275
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Concord, New Hampshire 03301
Principal Investigator: Douglas J. Weckstein
Phone: 603-224-2556
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Coos Bay, Oregon 97420
Principal Investigator: Gary E. Goodman
Phone: 541-269-8392
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Danville, Illinois 61832
Principal Investigator: Pratima Chalasani
Phone: 800-446-5532
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100 North Academy Avenue
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
570-271-6211
![Geisinger Medical Center](/wp-content/uploads/logos/geisinger-medical-center.jpg)
Principal Investigator: Victor G. Vogel
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
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1 Wyoming St,
Dayton, Ohio 45409
Dayton, Ohio 45409
(937) 208-8000
![Miami Valley Hospital](/wp-content/uploads/logos/miami-valley-hospital.png)
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital Miami Valley Hospital (MVH) is passionate about providing the most recent medical...
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Dayton, Ohio 45415
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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2222 Philadelphia Dr
Dayton, Ohio 45406
Dayton, Ohio 45406
(937) 734-2612
![Good Samaritan Hospital - Dayton](/wp-content/uploads/logos/good-samaritan-hospital---dayton.png)
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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9000 N. Main St.
Dayton, Ohio 45415
Dayton, Ohio 45415
(937) 734-6784
![Samaritan North Health Center](/wp-content/uploads/logos/samaritan-north-health-center.png)
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Samaritan North Health Center Good Samaritan Hospital (GSH) is passionate about providing the most recent...
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210 West McKinley Avenue
Decatur, Illinois 62526
Decatur, Illinois 62526
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
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2300 N Edward St
Decatur, Illinois 62526
Decatur, Illinois 62526
(217) 876-8121
![Decatur Memorial Hospital](/wp-content/uploads/logos/decatur-memorial-hospital.jpg)
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
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561 West Central Avenue
Delaware, Ohio 43015
Delaware, Ohio 43015
(740) 615-1000
![Delaware Health Center-Grady Cancer Center](/wp-content/uploads/logos/delaware-health-center-grady-cancer-center.jpg)
Principal Investigator: Timothy D. Moore
Phone: 740-615-0227
Delaware Health Center-Grady Cancer Center As the center of healthcare in Delaware County, Grady Memorial...
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561 W. Central Avenue
Delaware, Ohio 43015
Delaware, Ohio 43015
(740) 615-1000
![Grady Memorial Hospital](/wp-content/uploads/logos/grady-memorial-hospital.jpg)
Principal Investigator: Timothy D. Moore
Phone: 740-615-2403
Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
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Detroit, Michigan 48236
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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Easley, South Carolina 29640
Principal Investigator: Jeffrey K. Giguere
Phone: 864-241-6251
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17900 23 Mile Road
East China Township, Michigan 48054
East China Township, Michigan 48054
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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East Stroudsburg, Pennsylvania 18301
Principal Investigator: Christopher M. Reynolds
Phone: 570-422-1700
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Edmonds, Washington 98026
Principal Investigator: Gary E. Goodman
Phone: 206-215-3086
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Effingham, Illinois 62401
Principal Investigator: Pratima Chalasani
Phone: 800-446-5532
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Effingham, Illinois 62401
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
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Egg Harbor Township, New Jersey 08234
Principal Investigator: Victor G. Vogel
Phone: 609-748-7200
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Elmira, New York 14905
Principal Investigator: Serge Dauphin
Phone: 607-271-7000
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1202 East Locust Street
Emmett, Idaho 83617
Emmett, Idaho 83617
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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101 S Major St
Eureka, Illinois 61530
Eureka, Illinois 61530
309-467-2371
![Illinois CancerCare - Eureka](/wp-content/uploads/logos/illinois-cancercare---eureka.jpg)
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Eureka Illinois CancerCare is one of the largest private oncology and hematology...
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1717 13th St
Everett, Washington 98201
Everett, Washington 98201
(425) 297-5500
![Providence Regional Cancer Partnership](/wp-content/uploads/logos/providence-regional-cancer-partnership.png)
Principal Investigator: Gary E. Goodman
Phone: 425-261-3529
Providence Regional Cancer Partnership Founded in 2007, the Providence Regional Cancer Partnership is the result...
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Findlay, Ohio 45840
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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1900 S Main St
Findlay, Ohio 45840
Findlay, Ohio 45840
(419) 423-4500
![Blanchard Valley Hospital](/wp-content/uploads/logos/blanchard-valley-hospital.jpg)
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Blanchard Valley Hospital For more than 100 years, Blanchard Valley Hospital has made quality care...
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Flint, Michigan 48503
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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302 Kensington Avenue
Flint, Michigan 48503
Flint, Michigan 48503
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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302 Kensington Ave
Flint, Michigan 48503
Flint, Michigan 48503
(810) 762-8490
![Genesys Hurley Cancer Institute](/wp-content/uploads/logos/genesys-hurley-cancer-institute.jpg)
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
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1600 S Andrews Ave
Fort Lauderdale, Florida 33316
Fort Lauderdale, Florida 33316
(954) 355-4400
![Broward Health Medical Center](/wp-content/uploads/logos/broward-health-medical-center.png)
Principal Investigator: Mehmet F. Hepgur
Phone: 954-355-5346
Broward Health Medical Center Broward Health, providing service for more than 75 years, is a...
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Franklin, Ohio 45005
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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One Medical Center Drive
Franklin, Ohio 45005
Franklin, Ohio 45005
(513) 424-2111
![Atrium Medical Center - Middletown Regional Hospital](/wp-content/uploads/logos/atrium-medical-center---middletown-regional-hospital.png)
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Atrium Medical Center - Middletown Regional Hospital Atrium Medical Center (Atrium) is built on the...
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