A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata



Status:Recruiting
Conditions:Dermatology, Dermatology, Hair Loss
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - 70
Updated:4/5/2019
Start Date:September 24, 2018
End Date:August 5, 2022
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
Email:ClinicalTrials.gov@lilly.com
Phone:1-317-615-4559

Use our guide to learn which trials are right for you!

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients With Severe or Very Severe Alopecia Areata

This study is designed to select up to two doses of baricitinib (referred to as low dose and
high dose) and assess their efficacy and safety for the treatment of severe or very severe
alopecia areata.


Inclusion Criteria:

- Are at least 18 years and ≤60 years for males (≤70 years of age for females) at the
time of informed consent.

- Have severe or very severe AA, as determined by all of the following:

- Current AA episode of more than 6 months' duration and hair loss encompassing
≥50% of the scalp, as measured by SALT (AA-IGA of 3 or 4) at screening and
baseline.

- No spontaneous improvement over the past 6 months.

- Current episode of severe or very severe AA of less than 8 years. Note:
participants who have severe or very severe AA for ≥8 years may be enrolled if
episodes of regrowth, spontaneous or under treatment, have been observed on the
affected areas over the past 8 years.

- Male or nonpregnant, nonbreastfeeding female participants.

Exclusion Criteria:

- Primarily "diffuse" type of AA.

- Are currently experiencing other forms of alopecia or any other concomitant conditions
that would interfere with evaluations of the effect of study medication on AA.

- Previously treated with an oral Janus kinase (JAK) inhibitor and had an inadequate
response (for example, absence of significant terminal hair growth after at least 12
weeks of treatment).
We found this trial at
52
sites
Fort Smith, Arkansas 72916
Principal Investigator: Sandra Johnson
Phone: 479-649-3376
?
mi
from
Fort Smith, AR
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Tiffany Mayo
Phone: 205-502-9960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Maryanne Senna
Phone: 617-726-2914
?
mi
from
Boston, MA
Click here to add this to my saved trials
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Arash Mostaghimi
Phone: 617-525-8335
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
?
mi
from
Boston, MA
Click here to add this to my saved trials
3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Principal Investigator: Steven Robert Cohen
Phone: 7189202176
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
?
mi
from
Bronx, NY
Click here to add this to my saved trials
9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Principal Investigator: Wilma Bergfeld
Phone: 216-444-5725
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Miami, Florida 33124
(305) 284-2211
Principal Investigator: Antonella Tosti
Phone: 305-243-8205
University of Miami A private research university with more than 15,000 students from around the...
?
mi
from
Miami, FL
Click here to add this to my saved trials
7810 Louis Pasteur
San Antonio, Texas 78229
210-692-1382
Principal Investigator: Steven Andrew Davis
Phone: 2106921382
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
6565 West Loop South Freeway
Bellaire, Texas 77401
Principal Investigator: Craig Teller
Phone: 832-553-2318
?
mi
from
Bellaire, TX
Click here to add this to my saved trials
Beverly, Massachusetts 01915
Principal Investigator: David S Greenstein
Phone: 978-969-6897
?
mi
from
Beverly, MA
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Lara Wine Lee
Phone: 843-792-5858
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Maria Colavincenzo
Phone: 312-503-5944
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Clarkston, Michigan 48346
Principal Investigator: Wendy McFalda
Phone: 248-620-3376
?
mi
from
Clarkston, MI
Click here to add this to my saved trials
Cleveland, Ohio 44012
Principal Investigator: Neil J Korman
Phone: 216-844-5197
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Dallas, Texas 75231
Principal Investigator: Jennifer A Cather
Phone: 214-361-2008
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Encinitas, California 92024
Principal Investigator: Stacy R. Smith
Phone: 760-203-3839
?
mi
from
Encinitas, CA
Click here to add this to my saved trials
Exton, Pennsylvania 19341
Principal Investigator: Scott L Gottlieb
Phone: 610-594-6660
?
mi
from
Exton, PA
Click here to add this to my saved trials
920 North Hamilton Road
Gahanna, Ohio 43230
Principal Investigator: Jessica Kaffenberger
Phone: 614-366-9201
?
mi
from
Gahanna, OH
Click here to add this to my saved trials
Glenn Dale, Maryland 20769
Principal Investigator: Valerie Callender
Phone: 301-249-0970
?
mi
from
Glenn Dale, MD
Click here to add this to my saved trials
Houston, Texas 77030
Principal Investigator: Stephen K. Tyring
Phone: 713-528-8818
?
mi
from
Houston, TX
Click here to add this to my saved trials
Irvine, California 92697
949-824-5011
Principal Investigator: Natasha Mesinkovska
Phone: 949-824-7103
University of California, Irvine Since 1965, the University of California, Irvine has combined the strengths...
?
mi
from
Irvine, CA
Click here to add this to my saved trials
Jacksonville, Florida
Principal Investigator: Pearl Kwong
Phone: 904-619-8157
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Kurume, Fukuoka 83000
Principal Investigator: Norito Ishii
Phone: 81120360605
?
mi
from
Kurume,
Click here to add this to my saved trials
Laguna Hills, California 92653
Principal Investigator: Kenneth Deck
Phone: 949-680-3490
?
mi
from
Laguna Hills, CA
Click here to add this to my saved trials
Los Angeles, California 90045
Principal Investigator: Howard L Sofen
Phone: 310-337-7171
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Louisville, Kentucky 40202
Principal Investigator: Cindy E Owen
Phone: 502-585-9059
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Macon, Georgia 31217
Principal Investigator: David J Cohen
Phone: 478-742-2180
?
mi
from
Macon, GA
Click here to add this to my saved trials
Minneapolis, Minnesota 55455
Principal Investigator: Maria K Hordinsky
Phone: 612-625-6118
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
Mobile, Alabama 36608
Principal Investigator: Aldo Trovato
Phone: 251-414-1984
?
mi
from
Mobile, AL
Click here to add this to my saved trials
243 6100 South
Murray, Utah 84107
Principal Investigator: Gerald G Krueger
Phone: 801-213-0375
?
mi
from
Murray, UT
Click here to add this to my saved trials
333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Principal Investigator: Brett A King
Phone: 203-577-1050
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
Newnan, Georgia 30263
Principal Investigator: Mark R Ling
Phone: 770-252-6900
?
mi
from
Newnan, GA
Click here to add this to my saved trials
Orange Park, Florida 32073
Principal Investigator: George Schmieder
Phone: 904-458-0411
?
mi
from
Orange Park, FL
Click here to add this to my saved trials
Pflugerville, Texas 78660
Principal Investigator: Edward Lain
Phone: 512-279-2545
?
mi
from
Pflugerville, TX
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
Principal Investigator: Susan Taylor
Phone: 215-615-2934
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
200 Lothrop St
Pittsburgh, Pennsylvania 15213
Principal Investigator: Laura K Ferris
Phone: 412-647-2013
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Plymouth Meeting, Pennsylvania 19462
Principal Investigator: Jonathan Wolfe
Phone: 610-828-0400
?
mi
from
Plymouth Meeting, PA
Click here to add this to my saved trials
Portland, Oregon 97210
Principal Investigator: Janet Roberts
Phone: 503-223-1933
?
mi
from
Portland, OR
Click here to add this to my saved trials
3303 Southwest Bond Avenue
Portland, Oregon 97239
Principal Investigator: Teri Ms Greiling
Phone: 503-494-4770
?
mi
from
Portland, OR
Click here to add this to my saved trials
Portland, Oregon 97223
Principal Investigator: Andrew Blauvelt
Phone: 503-245-1525
?
mi
from
Portland, OR
Click here to add this to my saved trials
Portsmouth, New Hampshire 03801
Principal Investigator: Abel Jarell
Phone: 603-319-8863
?
mi
from
Portsmouth, NH
Click here to add this to my saved trials
Redwood City, California 94063
Principal Investigator: Justin Ko
Phone: 650-721-7167
?
mi
from
Redwood City, CA
Click here to add this to my saved trials
Rochester, New York 14642
Principal Investigator: Mary Gail Mercurio
Phone: 5852734421
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Sacramento, California 95816
Principal Investigator: Emanual Maverakis
Phone: 916-734-8254
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
San Antonio, Texas 78218
Principal Investigator: John C. Browning
Phone: 210-829-5180
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Antonio, Texas 78249
Principal Investigator: Stephen L Miller
Phone: 215-615-2934
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Diego, California 92123
Principal Investigator: Walter K Nahm
Phone: 858-278-8470
?
mi
from
San Diego, CA
Click here to add this to my saved trials
1821 Wilshire Boulevard
Santa Monica, California 90403
Principal Investigator: Vandana Madkan
Phone: 310-453-3101
?
mi
from
Santa Monica, CA
Click here to add this to my saved trials
Seattle, Washington 98101
Principal Investigator: Peter J Jenkin
Phone: 206-315-0377
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Tampa, Florida 33624
Principal Investigator: Seth B Forman
Phone: 813-960-2400
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Washington, District of Columbia 20060
Principal Investigator: Ginette Okoye
Phone: 202-865-4330
?
mi
from
Washington,
Click here to add this to my saved trials
Webster, Texas 77598
Principal Investigator: Patricia C. Lee
Phone: 281-333-2288
?
mi
from
Webster, TX
Click here to add this to my saved trials