CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/24/2019
Start Date:March 27, 2018
End Date:September 30, 2022
Contact:Clinical Trials Administrator
Email:clinicaltrials@calithera.com
Phone:650-870-1000

Use our guide to learn which trials are right for you!

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial Comparing CB-839 in Combination With Cabozantinib (CB-Cabo) vs. Placebo With Cabozantinib (Pbo-Cabo) in Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC)

This clinical trial is a randomized Phase 2 evaluation of CB-839 (telaglenastat) in
combination with cabozantinib versus placebo with cabozantinib in patients with advanced or
metastatic Renal Cell Carcinoma with a clear cell component.

This clinical trial is a randomized Phase 2 evaluation of CB-839 (telaglenastat) in
combination with cabozantinib versus placebo with cabozantinib in Renal Cell Carcinoma
patients with at least one and not more than 2 prior therapies in the advanced or metastatic
setting.

Inclusion Criteria:

1. Documented histological or cytological diagnosis of renal cell carcinoma with a
clear-cell component

2. Adult patients

3. Karnofsky Performance Score (KPS) ≥ 70%

4. Measurable Disease per RECIST 1.1

5. 1-2 lines of prior therapy for advanced or metastatic RCC including one
anti-angiogenic therapy (any VEGF pathway-targeted agent used either as monotherapy or
as a component of a combination regimen) OR the combination regimen of nivolumab +
ipilimumab

6. Adequate hepatic, renal, cardiac and hematologic function

Exclusion Criteria:

1. Prior treatment with cabozantinib (or other MET inhibitor) or CB-839

2. Receipt of other anticancer therapy within 2-6 weeks, depending on the treatment

3. Untreated or active brain metastases or central nervous system cancer, as defined per
protocol

4. Prior gastric surgery, small bowel resection, or other conditions that may impede
adequate absorption of oral study drug

5. Known active infection with HIV, Hepatitis B or C virus

6. Inability to discontinue proton-pump-inhibitor use before randomization

7. Patients who are pregnant or lactating
We found this trial at
54
sites
259 1st Street
Mineola, New York 11501
Principal Investigator: Mary O'Keeffe, MD
Phone: 516-663-3115
?
mi
from
Mineola, NY
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Richard Lee, M.D., Ph.D.
Phone: 617-724-4000
?
mi
from
Boston, MA
Click here to add this to my saved trials
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: David F McDermott, MD
Phone: 617-975-7412
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Walter Stadler, MD
University of Chicago One of the world's premier academic and research institutions, the University of...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
Principal Investigator: James Reeves, MD
Phone: 239-274-9930
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Nancy Davis, MD
Phone: 615-875-7981
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Ajjai Alva, MD
Phone: 800-865-1125
University of Michigan The University of Michigan was founded in 1817 as one of the...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Atlanta, Georgia 30322
Principal Investigator: Bradley Carthon, MD
Phone: 404-778-3492
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Augusta, Georgia 30912
Principal Investigator: Jigarkumar Parikh, MD
Phone: 706-721-1206
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Baltimore, Maryland 20742
(301) 405-1000
Principal Investigator: Arif Hussain, MD
Phone: 410-328-8739
University of Maryland As a globally-connected university offering a world-class education, the University of Maryland...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Boise, Idaho 83712
Principal Investigator: Rafael Arteta-Bulos, MD
Phone: 208-381-2774
?
mi
from
Boise, ID
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Bradley McGregor, M.D., Ph.D.
Phone: 617-582-7334
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bowral, New South Wales
Principal Investigator: Stephen Della-Fiorentina, MD
Phone: +61 02 4862 9469
?
mi
from
Bowral,
Click here to add this to my saved trials
Buffalo, New York 14263
Principal Investigator: Saby George, MD
Phone: 716-845-8313
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Theodore Gourdin, MD
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlotte, North Carolina 28211
Principal Investigator: Claud Grigg, MD
Phone: 908-307-0670
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Jeffrey Sosman, MD
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Colorado Springs, Colorado 80907
Principal Investigator: Maurice Markus, MD
Phone: 719-776-6550
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
Detroit, Michigan 48201
Principal Investigator: Ulka Vaishampayan, MD
Phone: 313-576-9372
?
mi
from
Detroit, MI
Click here to add this to my saved trials
East Setauket, New York 11733
Principal Investigator: David Chu, MD
Phone: 631-675-5075
?
mi
from
East Setauket, NY
Click here to add this to my saved trials
Farmington, New Mexico 87401
Principal Investigator: Sardar Imam, MD
Phone: 505-564-6874
?
mi
from
Farmington, NM
Click here to add this to my saved trials
Fort Worth, Texas 76104
Principal Investigator: Ray Page, DO
Phone: 817-759-7013
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Germantown, Tennessee 38138
Principal Investigator: Daniel Vaena, MD
Phone: 901-683-0055
?
mi
from
Germantown, TN
Click here to add this to my saved trials
Goshen, Indiana 46526
Principal Investigator: Sachin Agarwal, MD
Phone: 574-364-2974
?
mi
from
Goshen, IN
Click here to add this to my saved trials
Greenville, South Carolina
Principal Investigator: Robert Siegel, MD
Phone: 864-603-6214
?
mi
from
Greenville, SC
Click here to add this to my saved trials
Hattiesburg, Mississippi 39401
Principal Investigator: John Hrom, MD
Phone: 601-261-1700
?
mi
from
Hattiesburg, MS
Click here to add this to my saved trials
1 Salt Creek Lane
Hinsdale, Illinois 60521
Principal Investigator: Donald Sweet, MD
Phone: 630-286-5543
?
mi
from
Hinsdale, IL
Click here to add this to my saved trials
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
Principal Investigator: Nizar Tannir, MD
Phone: 713-563-1895
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
?
mi
from
Houston, TX
Click here to add this to my saved trials
Joplin, Missouri 64804
Principal Investigator: Samir Dalia, MD
Phone: 417-556-3074
?
mi
from
Joplin, MO
Click here to add this to my saved trials
2316 East Meyer Boulevard
Kansas City, Missouri 64132
Principal Investigator: Peter Van Veldhuizen, MD
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kennewick, Washington 99336
Principal Investigator: Rangaswamy Chintapatla, MD
Phone: 509-783-4637
?
mi
from
Kennewick, WA
Click here to add this to my saved trials
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Principal Investigator: Oscar Goodman, MD
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Los Angeles, California 90048
Principal Investigator: Robert Figlin, MD
Phone: 310-423-3713
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Marietta, Georgia 30060
Principal Investigator: Steve McCune, MD
Phone: 770-281-5010
?
mi
from
Marietta, GA
Click here to add this to my saved trials
Metairie, Louisiana 70006
Principal Investigator: Thomas Cosgriff, MD
Phone: 504-503-5368
?
mi
from
Metairie, LA
Click here to add this to my saved trials
1475 NW 12th Ave
Miami, Florida 33136
(305) 243-1000
Principal Investigator: Jaime Merchan, MD
Phone: 305-243-4903
University of Miami, Sylvester Comprehensive Cancer Center Sylvester Comprehensive Cancer Center integrates all cancer-related activities...
?
mi
from
Miami, FL
Click here to add this to my saved trials
Milwaukee, Wisconsin
Principal Investigator: Deepak Kilari, MD
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Mount Kisco, New York 10549
Principal Investigator: Jonathan Goldberg, MD
Phone: 914-241-1050
?
mi
from
Mount Kisco, NY
Click here to add this to my saved trials
3322 West End Avenue
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Principal Investigator: Johanna Bendell, MD
Phone: 844-482-4812
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73142
Principal Investigator: Romeo A Mandanas, MD
Phone: 405-773-6613
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Palo Alto, California 94304
Principal Investigator: Alice Fan, MD
Phone: 650-725-9180
?
mi
from
Palo Alto, CA
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19111
Principal Investigator: Daniel Geynisman, MD
Phone: 215-728-3889
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Phoenix, Arizona 85054
Principal Investigator: Thai Ho, MD
Phone: 855-776-0015
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Principal Investigator: Shifeng Mao, MD
Phone: 412-359-8379
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
5115 Centre Avenue
Pittsburgh, Pennsylvania 15232
Principal Investigator: Leonard Appleman, MD
Phone: 412-623-4891
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Saint Petersburg, Florida 33705
Principal Investigator: Sunil Gandhi, MD
Phone: 239-274-9930
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Salinas, California 93901
Principal Investigator: Geetha Varma, MD
?
mi
from
Salinas, CA
Click here to add this to my saved trials
Salt Lake City, Utah 84112
Principal Investigator: Neeraj Agarwal, MD
Phone: 801-213-6232
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
San Diego, California 92093
Principal Investigator: Rana McKay, MD
Phone: 858-822-5398
?
mi
from
San Diego, CA
Click here to add this to my saved trials
3 Edmund D. Pellegrino Road
Stony Brook, New York 11794
Principal Investigator: Yue Zhang, MD
Phone: 631-638-0829
?
mi
from
Stony Brook, NY
Click here to add this to my saved trials
Tampa, Florida 33612
Principal Investigator: Rohit Jain, MD
Phone: 813-745-2226
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Tucson, Arizona 85724
Principal Investigator: Montaser Shaheen, MD
Phone: 520-626-0501
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Warrenville, Illinois 60555
Principal Investigator: Christopher George, MD
Phone: 630-232-0610
?
mi
from
Warrenville, IL
Click here to add this to my saved trials
3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 687-7695
Principal Investigator: Nancy Dawson, MD
Phone: 202-444-2198
Georgetown University Medical Center Georgetown University Medical Center is committed to excellence in research, education...
?
mi
from
Washington,
Click here to add this to my saved trials