Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia



Status:Recruiting
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:11/23/2018
Start Date:August 16, 2017
End Date:August 18, 2025

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A Simplified Patient Care Strategy to Decrease Early Deaths in Acute Promyelocytic Leukemia (APL)

This clinical trial studies how well simplified patient care strategy works in decreasing
early death in patients with acute promyelocytic leukemia. Implementing simplified acute
promyelocytic leukemia guidelines along with support from acute promyelocytic leukemia
experts may decrease deaths and improve survival.

PRIMARY OBJECTIVES:

I. To evaluate if the proposed patient care strategy, that includes use of simplified
guidelines along with acute promyelocytic leukemia (APL) expert support, decreases the
one-month induction mortality rate from 30% to under 15%.

SECONDARY OBJECTIVES:

I. To assess the overall survival 1 year after accrual is completed. II. To assess incidence
and severity of differentiation syndrome. III. To correlate outcomes with time to initiation
of all-trans retinoic acid (ATRA) from diagnosis or suspicion of diagnosis.

IV. To compare outcomes between academic and community centers separately. V. To evaluate
factors associated with outcome.

OUTLINE:

Patients receive standard of care treatment for APL. Patients? doctors regularly discuss with
an APL expert to identify and mange treatment.

After diagnosis, patients are followed up for 1 year.

Inclusion Criteria:

- Confirmed to have a diagnosis of APL, which is defined as:

- Positive t(15:17) by fluorescence in situ hybridization (FISH) or conventional
karyotype

- Positive promyelocytic leukemia/retinoic acid receptor PML/RAR alpha by
polymerase chain reaction (PCR)

- Patients must accept treatment and supportive care guidelines

- Referrals must be made as early as possible but no later than 5 calendar days after
ATRA therapy is initiated; consent can be obtained up till day 7 or earlier

- Co-management can be started as soon as referral is made including weekends; the
physician at the outlying facility should make every effort to call the APL expert at
the first suspicion of APL
We found this trial at
113
sites
2000 N Boise Ave
Loveland, Colorado 80538
(970) 669-4640
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
McKee Medical Center Through the years, McKee has led the way in health care innovation....
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1111 Duff Ave
Ames, Iowa 50010
(866) 972-5477
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
McFarland Clinic PC-William R Bliss Cancer Center The William R. Bliss Cancer Center at Mary...
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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Antioch, California 94531
Principal Investigator: Louis Fehrenbacher
Phone: 626-564-3455
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Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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1300 Anne Street NW
Bemidji, Minnesota 56601
(218) 751-5430
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Sanford Clinic North-Bemidgi Sanford Health is a voluntary, not-for-profit health care organization. Through its entities,...
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300 N. Seventh St.
Bismarck, North Dakota 58501
(701) 323-6000
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Sanford Bismarck Medical Center Whether your stay in our hospital is one day for same...
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1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
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Bonne Terre, Missouri 63628
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Boone, Iowa 50036
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
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Boulder, Colorado 80303
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Brainerd, Minnesota 56401
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
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210 W Walnut St
Canton, Illinois 61520
309-647-5240
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: James L. Wade
Phone: 309-243-3605
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
(573) 519-4725
Principal Investigator: James L. Wade
Phone: 309-243-3605
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
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Carbondale, Illinois 62902
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Carterville, Illinois 62918
Principal Investigator: James L. Wade
Phone: 309-243-3605
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160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Centralia, Illinois 62801
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Cheyenne, Wyoming 82001
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Jessica K. Altman
Phone: 312-503-1817
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Decatur, Illinois 62526
Principal Investigator: James L. Wade
Phone: 309-243-3605
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2300 N Edward St
Decatur, Illinois 62526
(217) 876-8121
Principal Investigator: James L. Wade
Phone: 309-243-3605
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
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777 Bannock St
Denver, Colorado 80204
(303) 436-6000
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Denver Health Medical Center Denver Health is a comprehensive, integrated organization providing level one care...
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4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
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1721 East 19th Ave., Suite #200 & #300
Denver, Colorado 80218
720-754-4800
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Colorado Blood Cancer Institute When patients come to the Colorado Blood Cancer Institute, the entire...
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Denver, Colorado 80218
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Denver, Colorado 80220
Principal Investigator: Keren Sturtz
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Denver, Colorado 80218
Principal Investigator: Keren Sturtz
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Denver, Colorado 80206
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Denver, Colorado 80218
Principal Investigator: Keren Sturtz
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3773 Chry Crk North Dr # 101
Denver, Colorado 80209
Principal Investigator: Keren Sturtz
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Duluth, Minnesota 55805
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
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Duluth, Minnesota 55805
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
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Duluth, Minnesota 55805
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
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Effingham, Illinois 62401
Principal Investigator: James L. Wade
Phone: 309-243-3605
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501 E. Hampden Ave.
Englewood, Colorado 80113
303-788-5000
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Phone: 303-777-2663
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Englewood, Colorado 80113
Principal Investigator: Keren Sturtz
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101 S Major St
Eureka, Illinois 61530
309-467-2371
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Eureka Illinois CancerCare is one of the largest private oncology and hematology...
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820 4th St N
Fargo, North Dakota 58102
(701) 234-6161
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Roger Maris Cancer Center Sanford Health is an integrated health system headquartered in the Dakotas...
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Fargo, North Dakota 58103
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801 Broadway North
Fargo, North Dakota 58122
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Fergus Falls, Minnesota 56537
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Fort Dodge, Iowa 50501
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39400 Paseo Padre Parkway
Fremont, California 94538
(510) 248-3000
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Kaiser Permanente - Fremont You can rely on Kaiser Permanente for quality care, delivered with...
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505 East Alluvial Avenue
Fresno, California 93720
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Fresno, California 93720
Principal Investigator: Louis Fehrenbacher
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3315 N Seminary St
Galesburg, Illinois 61401
309-344-9269
Principal Investigator: James L. Wade
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Illinois CancerCare - Galesburg Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Galesburg, Illinois 61401
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Golden, Colorado 80401
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1801 16th St
Greeley, Colorado 80631
(970) 352-4121
Principal Investigator: Keren Sturtz
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North Colorado Medical Center NCMC is a fully accredited, private, non-profit facility licensed to operate...
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Greenwood Village, Colorado 80111
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Honolulu, Hawaii 96819
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4500 San Pablo Rd S
Jacksonville, Florida 32224
(904) 953-2000
Principal Investigator: James M. Foran
Phone: 904-953-7292
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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Jefferson, Iowa 50129
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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1432 Southwest Blvd.
Jefferson City, Missouri 65109
(573) 632-4800
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Capital Region Medical Center-Goldschmidt Cancer Center At the Goldschmidt Cancer Center in Jefferson City, board...
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205 Tenney St
Kewanee, Illinois 61443
309-852-0596
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Kewanee Clinic Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer...
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Littleton, Colorado 80120
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Lone Tree, Colorado 80124
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501 E Grant
Macomb, Illinois 61455
309-833-3503
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Macomb Illinois CancerCare is one of the largest private oncology and hematology...
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Marshalltown, Iowa 50158
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Memphis, Tennessee 38120
Principal Investigator: Salil Goorha
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Modesto, California 95356
Principal Investigator: Louis Fehrenbacher
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Martin S. Tallman
Phone: 212-639-3842
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Oakland, California 94611
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Oakland, California 94611
Principal Investigator: Louis Fehrenbacher
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1200 Starfire Drive
Ottawa, Illinois 61350
815-431-9270
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Illinois CancerCare-Ottawa Clinic Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases....
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603 S 13th St
Pekin, Illinois 61554
(309) 353-0214
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Pekin, Illinois 61554
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221 NE Glen Oak Ave
Peoria, Illinois 61636
(309) 672-5522
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Methodist Medical Center of Illinois UnityPoint Health is one of the nation's most integrated health...
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8940 Wood Sage Rd
Peoria, Illinois 61615
(309) 243-3000
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Illinois CancerCare-Peoria Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
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Peoria, Illinois 61615
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Peoria, Illinois 61637
Principal Investigator: James L. Wade
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4391 Venture Dr.
Peru, Illinois 61354
815-223-7010
Principal Investigator: James L. Wade
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Illinois CancerCare - Peru Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Peru, Illinois 61354
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Philadelphia, Pennsylvania 19104
Principal Investigator: Selina M. Luger
Phone: 215-662-6348
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Philadelphia, Pennsylvania 19103
Principal Investigator: Anand P. Jillella
Phone: 404-778-1900
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530 Park Ave East
Princeton, Illinois 61356
815-875-3010
Principal Investigator: James L. Wade
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Illinois CancerCare - Princeton Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Rancho Cordova, California 95670
Principal Investigator: Louis Fehrenbacher
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Redwood City, California 94063
Principal Investigator: Louis Fehrenbacher
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Richmond, California 94801
Principal Investigator: Louis Fehrenbacher
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Rochester, Minnesota 55905
Principal Investigator: Mark R. Litzow
Phone: 507-266-0523
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Rohnert Park, California 94928
Principal Investigator: Louis Fehrenbacher
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Roseville, California 95678
Principal Investigator: Louis Fehrenbacher
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Roseville, California 95678
Principal Investigator: Louis Fehrenbacher
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Sacramento, California 95823
Principal Investigator: Louis Fehrenbacher
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Sacramento, California 95823
Principal Investigator: Louis Fehrenbacher
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6600 Bruceville Road
Sacramento, California 95823
(916) 688-2000
Principal Investigator: Louis Fehrenbacher
Phone: 626-564-3455
Kaiser Permanente - Sacramento At the Kaiser Permanente South Sacramento Medical Center, you and your...
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3015 North Ballas Road
Saint Louis, Missouri 63131
(314) 996-5000
Principal Investigator: James L. Wade
Phone: 309-243-3605
Missouri Baptist Medical Center You just feel it. The smile that greets you. The hand...
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Sainte Genevieve, Missouri 63670
Principal Investigator: James L. Wade
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San Francisco, California 94115
Principal Investigator: Louis Fehrenbacher
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San Jose, California 95119
Principal Investigator: Louis Fehrenbacher
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San Leandro, California 94577
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700 Lawrence Expy
Santa Clara, California 95051
(408) 851-1000
Principal Investigator: Louis Fehrenbacher
Phone: 626-564-3455
Kaiser Permanente Medical Center - Santa Clara At Kaiser Permanente Santa Clara, members and patients...
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Santa Rosa, California 95403
Principal Investigator: Louis Fehrenbacher
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1305 W 18th St
Sioux Falls, South Dakota 57117
(605) 333-1000
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Sanford USD Medical Center - Sioux Falls Sanford
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1309 W 17th Street
Sioux Falls, South Dakota 57104
(605) 328-8000
Principal Investigator: Preston D. Steen
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Sanford Cancer Center-Oncology Clinic Sanford Health is an integrated health system headquartered in the Dakotas...
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South San Francisco, California 94080
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South San Francisco, California 94080
Principal Investigator: Louis Fehrenbacher
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Springfield, Illinois 62703
Principal Investigator: James L. Wade
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