Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:3/13/2019
Start Date:September 21, 2017
End Date:February 28, 2019

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Phase III Randomized Adjuvant Study of MK-3475 (Pembrolizumab) in Muscle Invasive and Locally Advanced Urothelial Carcinoma (AMBASSADOR) Versus Observation

This randomized phase III trial studies how well pembrolizumab works in treating patients
with bladder cancer that has spread from where it started to nearby tissue or lymph nodes.
Monoclonal antibodies recognizing and blocking checkpoint molecules can enhance the patient's
immune response and therefore help fight cancer. Pembrolizumab is one of the monoclonal
antibodies that block the PD-1 axis and can interfere with the ability of tumor cells to
grow.

PRIMARY OBJECTIVES:

I. To determine disease free survival (DFS) and overall survival (OS) in all patients with
muscle-invasive bladder and upper-tract urothelial carcinoma treated with adjuvant
pembrolizumab (MK-3475) versus (vs.) observation.

SECONDARY OBJECTIVES:

I. To determine DFS and OS in PD-L1 positive and negative patients with muscle-invasive
bladder and upper-tract urothelial carcinoma treated with adjuvant MK-3475 (pembrolizumab)
vs. observation.

II. To characterize the safety and tolerability of MK-3475 (pembrolizumab) when administered
in the adjuvant setting in patients with muscle-invasive bladder and upper-tract urothelial
carcinoma.

TERTIARY OBJECTIVES:

I. To determine if the 12 immune gene signatures are associated with OS and DFS.

II. To determine if tumor molecular subtype is associated with OS and DFS. III. To
investigate whether the diversity of T-cell receptor (TCR) clonotypes is associated with OS
and DFS.

IV. To investigate whether persistence of TCR clonotypes is associated with OS and DFS.

V. To determine if tumor burden and neoantigen burden are associated with OS and DFS.

VI. To determine if HLA subtypes are associated with OS and DFS. VII. To conduct exploratory
analyses regarding the association of plasma HGF and VEGF levels with IL-10 and IL-17 and OS
and DFS and between treated and untreated patients.

VIII. To investigate the effect of PDCD1 single-nucleotide polymorphism (SNP) rs11568821 on
severe (grade 3 or higher) immune-related toxicity in the MK-3475 (pembrolizumab)-treated
cohort.

IX. To investigate whether other SNPs commonly polymorphic within or near PDCD1 associate
with development of MK-3475 (pembrolizumab) toxicity in the treated cohort.

X. To identify novel germline genetic markers of treatment-related toxicity through
genome-wide association analysis of pembrolizumab-treated patients.

XI. To identify novel germline genetic markers that are associated with DFS and OS through
genome-wide association analysis.

XII. To compare health-related quality of life (HRQL) as assessed by the European
Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire
(QLQ)-core (C)30 between patients randomized to MK-3475 (pembrolizumab) vs. observation.

XIII. To compare urinary symptoms as assessed by EORTC QLQ- muscle-invasive bladder cancer
module (BLM)30 between patients randomized to MK-3475 (pembrolizumab) vs. observation.

XIV. To compare patient-reported fatigue, diarrhea, and pain between patients randomized to
MK-3475 (pembrolizumab) vs. observation.

XV. To compare health utilities and quality-adjusted life year (QALYs) between patients
randomized to MK-3475 (pembrolizumab) vs. observation.

XVI. To compare other scale scores of the EORTC QLQ-C30, EORTC QLQ-BLM30, and European
Quality of Life 5 Dimensions 5 Levels (EQ5D-5L) between patients randomized to MK-3475
(pembrolizumab) vs. observation.

XVII. To compare global quality of life, symptoms, health utilities, QALYs, and other scale
scores of the three questionnaires between patients randomized to MK-3475 (pembrolizumab) vs.
observation within subgroups defined by each of the stratification factors.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment
repeats every 21 days for up to 18 courses in the absence of disease progression or
unacceptable toxicity.

ARM B: Patients undergo observation.

After completion of study treatment, patients are followed up every 12 weeks for up 2 years,
and then annually for 3 years.

Inclusion Criteria:

- PRE-REGISTRATION ELIGIBILITY CRITERIA

- Histologically confirmed muscle-invasive urothelial carcinoma of the bladder or upper
tract; variant histology allowed as long as urothelial carcinoma is predominant (>
50%); pure small-cell carcinoma is excluded

- Paraffin tissue samples obtained by transurethral resection of muscle-invasive bladder
tumor, upper tract resection, cystectomy/nephrectomy/ureterectomy, or
nephroureterectomy must be available; this specimen submission is mandatory prior to
registration as results will be used for stratification

- Patient must fit into one of the following three categories:

- Patients who received neoadjuvant chemotherapy and pathologic stage at surgical
resection is >= pT2 and/or N+ OR

- Patients who are not cisplatin-eligible (according to >= 1 of the following
criteria: Eastern Cooperative Oncology Group [ECOG] performance status of 2,
creatinine clearance < 60 mL/min, grade >= 2 hearing loss, grade >= 2 neuropathy,
or New York Heart Association class III heart failure and pathologic stage at
surgical resection is >= pT3 or pN+) OR

- Patients that decline adjuvant cisplatin-based or other systemic chemotherapy
based on an informed discussion with the physician and pathologic stage at
surgical resection is >= pT3 or pN+

- Patient must have had radical surgical resection of their bladder cancer >= 4 weeks
but =< 16 weeks prior to pre-registration

- No invasive cancer at the surgical margins

- No evidence of residual cancer or metastasis after surgery

- No metastatic disease on cross-sectional imaging (according to Response Evaluation
Criteria in Solid Tumors [RECIST] version [v]1.1 criteria)

- No active autoimmune disease or history of autoimmune disease that might recur, which
may affect vital organ function or require immune suppressive treatment including
systemic corticosteroids; these include but are not limited to patients with a history
of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating)
neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease
such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma,
inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients
with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or
phospholipid syndrome because of the risk of recurrence or exacerbation of disease;
human immunodeficiency virus (HIV) (+) patients are eligible as long as they have: cd4
> 200, undetectable viral load and on highly active antiretroviral therapy (HAART)
therapy

- No current pneumonitis or prior history of non-infectious pneumonitis that required
steroids within the previous 5 years

- Patients with vitiligo, endocrine deficiencies including type I diabetes mellitus,
thyroiditis managed with replacement hormones including physiologic corticosteroids
are eligible

- Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and
psoriasis controlled with topical medication and patients with positive serology, such
as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the
presence of target organ involvement and potential need for systemic treatment but
should otherwise be eligible

- No known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or
hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is
detected)

- No postoperative/adjuvant systemic therapy

- No prior treatment with any therapy on the PD-1/PD-L1 axis

- No treatment with any other type of investigational agent =< 4 weeks before
pre-registration

- No major surgery =< 4 weeks before pre-registration

- No radiation therapy =< 4 weeks before pre-registration

- No neoadjuvant chemotherapy =< 4 weeks before pre-registration

- Not pregnant and not nursing

- ECOG performance status =< 2

- Absolute neutrophil count (ANC) >= 1,200/mm^3

- Leukocytes >= 3,000/ mm^3

- Platelet count >= 75,000/mm^3

- Hemoglobin >= 9 g/dL or >= 5.6 mmol/L

- Creatinine =< 2.0 x upper limit of normal (ULN) OR calculated (calc.) creatinine
clearance >= 30 mL/min

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit
of normal (ULN)

- Serum albumin >= 2.8 g/dL

- For women of childbearing potential only: a negative urine or serum pregnancy test
done =< 7 days prior to pre-registration is required

- REGISTRATION ELIGIBILITY CRITERIA

- Results of central PD-L1 testing available; Q2 Solutions will forward the PD-L1
results to the statistical center and the statistical center will notify the site that
the result is available; the notification from the Alliance registration/randomization
office will serve as a confirmation of this eligibility criteria; after sites receive
the confirmation e-mail from Alliance they can register the patient
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Bolivar, Missouri 65613
Principal Investigator: Rakesh Gaur
Phone: 800-328-6010
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Bolivar, MO
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Bonne Terre, Missouri 63628
Principal Investigator: Bryan A. Faller
Phone: 314-996-5569
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Bonne Terre, MO
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Boone, Iowa 50036
Principal Investigator: Joseph J. Merchant
Phone: 515-956-4132
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Boone, IA
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55 Fruit St
Boston, Massachusetts 02114
(617) 724-4000
Principal Investigator: Guru P. Sonpavde
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center An integral part of one of the world
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Boston, MA
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Guru P. Sonpavde
Phone: 877-442-3324
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Boston, Massachusetts 02118
Principal Investigator: Gretchen A. Gignac
Phone: 617-638-8265
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Boston, MA
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915 Highland Blvd
Bozeman, Montana 59715
(406) 414-5000
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Bozeman Deaconess Hospital Bozeman Deaconess Hospital is a Joint Commission certified, licensed Level III trauma...
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Bozeman, MT
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Branson, Missouri 65616
Principal Investigator: Jay W. Carlson
Phone: 417-269-4520
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Branson, MO
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Brewer, Maine 04412
Principal Investigator: Thomas H. Openshaw
Phone: 800-987-3005
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Brewer, ME
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7575 Grand River Avenue
Brighton, Michigan 48114
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Brighton, MI
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7575 Grand River Avenue
Brighton, Michigan 48114
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Brighton, MI
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Bristol, Tennessee 37620
Principal Investigator: Asheesh Shipstone
Phone: 423-578-8538
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Bristol, TN
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Bristol, Virginia 24201
Principal Investigator: Asheesh Shipstone
Phone: 423-578-8538
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Bristol, VA
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Bronx, New York 10468
Principal Investigator: Susan E. Bates
Phone: 718-584-9000
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Bronx, NY
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Bronx, New York 10467
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Bronx, New York 10461
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Bronx, New York 10461
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Brookfield, Wisconsin 53045
Principal Investigator: Jonathan S. Treisman
Phone: 262-687-5010
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Brookfield, WI
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4802 10th Ave
Brooklyn, New York 11219
(718) 283-6000
Principal Investigator: Kevin Becker
Phone: 718-765-2500
Maimonides Medical Center At 103 years old, Maimonides Medical Center remains a vital and thriving...
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Brooklyn, NY
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Burbank, California
Principal Investigator: Alison K. Conlin
Phone: 818-847-4793
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Burbank, CA
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