Breast Cancer WEight Loss Study (BWEL Study)



Status:Recruiting
Conditions:Breast Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/23/2019
Start Date:August 2016
Contact:Jennifer Ligibel, MD
Email:BWELStudy@partners.org
Phone:857-215-2935

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Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women With Early Breast Cancer

This randomized phase III trial studies whether weight loss in overweight and obese women may
prevent breast cancer from coming back (recurrence). Previous studies have found that women
who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk
of their breast cancer recurring, as compared to women who were thinner when their cancer was
diagnosed. This study aims to test whether overweight or obese women who take part in a
weight loss program after being diagnosed with breast cancer have a lower rate of cancer
recurrence as compared to women who do not take part in the weight loss program. This study
will help to show whether weight loss programs should be a part of breast cancer treatment.

This randomized controlled trial of weight loss interventions in overweight and obese women
with early stage breast cancer consists of two arms, please see the arms section for more
information. Patients will be randomized 1:1 within stratification factors: menopausal status
(premenopausal vs. postmenopausal), hormone receptor status of the tumor (ER and/or PR
positive vs. ER and PR negative), and race/ethnicity (African American vs. Hispanic vs.
Other). The primary objective of this trial is to compare the effect of the telephone-based
intervention versus a health educational control on invasive disease-free survival (IDFS).
The total sample size is 3136 patients. Patient follow up for primary and secondary endpoints
will continue to a maximum of 10 years, as per the standard protocol for cooperative group
adjuvant trials.

The primary and secondary objectives of the study:

Primary objective To compare the effect of a supervised weight loss intervention plus health
education materials versus health education materials alone upon invasive disease free
survival (IDFS) in overweight (BMI 27-29.9 kg/m2) and obese (BMI ≥30kg/m2) women diagnosed
with HER-2 negative, stage II and III breast cancer.

Secondary objectives

1. To determine the relationship between changes in weight and IDFS, and to explore
interaction between the level of clinical benefit from weight loss and the intervention.

2. To evaluate the effect of a supervised weight loss intervention upon:

1. Overall survival

2. Distant disease free survival

3. Weight

4. Body composition (as measured by waist and hip circumference)

5. Insulin Resistance Syndrome associated conditions - diabetes, hospitalization for
CV disease

3. To determine the impact of a supervised weight loss intervention on IDFS within
subgroups of women with 1) hormone receptor positive breast cancer and 2) hormone
receptor negative breast cancer.

4. To determine the impact of a supervised weight loss intervention on IDFS within
subgroups of 1) premenopausal women and 2) post-menopausal women.

Patients are to be followed every 6 months for the first 3 years after study enrollment and
then annually until 10 years from registration. The intervention will last 2 years or until
disease recurrence/progression, new invasive primary cancer as defined in the protocol or
patient withdrawal.

1. Documentation of Disease:

1.1 Subjects must have histologically confirmed invasive breast cancer and
registration must occur within 14 months after the first histologic diagnosis of
invasive breast cancer.

- A core biopsy interpreted as invasive cancer meets this criterion; if no core
biopsy is performed, the date of first histologic diagnosis will be the date of
first surgical procedure that identifies invasive cancer (biopsy, lumpectomy or
mastectomy).

- Neoadjuvant subjects should have no evidence of clinical T4 disease prior to
chemotherapy and surgery; eligibility for neoadjuvant patients can be defined by
either clinical stage prior to therapy or pathologic stage at surgery; if patient
is eligible based on either, they are eligible for the study.

- Bilateral breast carcinoma is allowed provided diagnoses are synchronous - that
is, within 3 months of one another - and at least one of the two breast
carcinomas meet the eligibility criteria and neither Her-2 positive or
inflammatory.

- No evidence of metastatic disease

1.2 Her-2 negative, defined as:

- In-situ hybridization (ISH) ratio of < 2.0 (if performed)

- Immunohistochemistry (IHC) staining of 0-2+ (if performed)

- Deemed to not be a candidate for Her-2 directed therapy.

1.3 Eligible tumor-node-metastasis (TNM) Stages include:

- Estrogen receptor (ER) and Progesterone receptor (PR) negative (defined as <1%
staining for ER and PR by IHC): T2 or T3 N0, T0-3N1-3. Note: Patients with T1,
N1mi disease are NOT eligible.

- ER and/or PR positive (defined as ≥ 1% staining for ER and/or PR on IHC):
T0-3N1-3 or T3N0. Note: Patients with T0N0, T1N0, T2N0 or T1N1mi and T2N1mi
disease are NOT eligible.

- The eligibility of neo-adjuvant subjects can be assessed on the basis of clinical
(c)TNM or pathologic (yp)TNM. The same eligible TNM combinations apply; patients
may be eligible if they meet eligibility requirements at either time point, as
long as they do not have T4 disease prior to therapy.

1.4 No history of invasive breast cancer in 5 years prior to study registration other
than the current diagnosis (prior ductal breast carcinoma in situ [DCIS] at any time
is acceptable).

1.5 Patients must have had a bilateral mammogram within 12 months prior to
registration, unless the initial surgery was a total mastectomy, in which case only a
mammogram of the remaining breast is required. (Subjects with bilateral total
mastectomies do not require imaging).

1.6 Investigations, including chest X-ray or computed tomography (CT) chest, bone scan
(with radiographs of suspicious areas) and abdominal ultrasound or liver scan or CT
abdomen have been performed between the first histologic diagnosis and the time of
registration as detailed below.

- Chest X-Ray, 2 view (or Chest CT, or positron emission tomography [PET]/CT) is
mandatory

- Bone scans (with x-rays of abnormal areas) are required only if alanine
aminotransferase (ALT), aspartate aminotransferase (AST) or Alkaline Phosphatase
is elevated or if there are signs or symptoms of metastatic disease

- Abdominal imaging is required only if ALT, AST or Alkaline Phosphatase is
elevated or if there are signs or symptoms of metastatic disease

2. Prior Treatment

2.1 All adjuvant or neoadjuvant chemotherapy, radiation, and surgery completed at
least 21 days prior to registration.

2.2 All triple negative patients must receive chemotherapy of the treating physician's
choice.

2.3 ER/PR+ patients must receive chemotherapy (of the treating physician's choice)
unless Oncotype Dx or another genomic predictor score indicates that they are at low
or intermediate risk of disease recurrence with endocrine therapy alone.

2.4 Patients may have breast reconstruction during protocol participation, but
definitive breast cancer surgery must be completed at least 21 days prior to
registration.

Concomitant biologic therapy, hormonal therapy, and bisphosphonates are acceptable.

2.5 Surgical margins must be clear of invasive carcinoma. If there is microscopic
residual ductal in situ disease present at lumpectomy or total mastectomy margins,
further excision is highly recommended. If further excision is not undertaken, the
subject may still be entered on study, provided that in addition to breast or chest
wall irradiation, a boost to the tumor bed is delivered. In situ lobular disease at
the margin is acceptable.

2.6 All subjects (both adjuvant and neoadjuvant) must have sentinel lymph node biopsy
and/or axillary lymph node dissection. Sentinel lymph node biopsy alone is allowed in
the following instances:

- Sentinel lymph node biopsy is negative: pN0

- Sentinel lymph node biopsy is positive for isolated tumor cells only:

pN0 (i+)

- Clinically node negative, T1-2 tumors with sentinel lymph node biopsy positive in
< 2 lymph nodes without matted nodes and undergoing breast conserving surgery and
tangential whole breast irradiation, or undergoing mastectomy and chest wall
irradiation.

- For patients who had a positive node prior to neoadjuvant chemotherapy, sentinel
node alone is allowed after neoadjuvant therapy if:

- Sentinel node biopsy is negative after chemotherapy and either at least 2
sentinel nodes were removed or a clip was placed in the involved node prior
to treatment.

- =< 2 lymph nodes are positive for cancer and the patient is participating in
A011202

- All women who undergo breast conserving therapy must receive concomitant
radiotherapy. Radiation after mastectomy is to be administered according to
prespecified institutional guidelines. Radiation must be completed at least 21
days prior to registration.

- Patients with hormone receptor positive breast cancer as defined above must
receive at least 5 years of adjuvant hormonal therapy in the form of tamoxifen or
an aromatase inhibitor, alone or in combination with ovarian suppression. (NOTE:
for patients with ER and PR staining in less than 5% of cells, hormonal therapy
for at least 5 years is strongly recommended but not required). Hormonal therapy
can be initiated prior to or during protocol therapy.

3. Participants must be women

4. Age ≥ 18 years

5. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1

6. Comorbid Conditions

6.1 No history of other malignancy within the past 4 years, except for malignancies
with a >95% likelihood of cure (e.g. non-melanoma skin cancer, papillary thyroid
cancer, in situ cervical cancer). Patients cannot have metastatic breast or other
cancer.

6.2 No diabetes mellitus currently treated with insulin or sulfonylureas.

6.3 No history of serious digestive and/or absorptive problems, including inflammatory
bowel disease and chronic diarrhea that preclude adherence to the study diet.

6.4 No history of severe cardiovascular, respiratory or musculoskeletal disease or
joint problems that preclude moderate physical activity. Examples would include
unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and
osteoarthritis requiring imminent joint replacement. Moderate arthritis that does not
preclude physical activity is not a reason for ineligibility.

6.5 No prior bariatric surgery or planning to undergo this procedure within the next 2
years after study registration.

6.6 No comorbid conditions that would cause life expectancy of less than 5 years.

6.7 No history of psychiatric disorders that would preclude participation in the study
intervention (e.g. untreated major depression or psychosis, substance abuse, severe
personality disorder) or prevent the patient from giving informed consent.

7. Other

7.1 BMI ≥27 kg/m2 documented within 56 days prior to study registration. The most recent
BMI obtained must be used for eligibility. If most recent BMI is <27 then the patient is
not eligible to enroll.

7.2 Self-reported ability to walk at least 2 blocks (at any pace).

7.3 Not participating in another weight loss, physical activity or dietary intervention
clinical trial. Co-enrollment in some trials involving pharmacologic therapy is allowed.
Participants in both arms are also allowed to pursue weight loss and physical activity
programs on their own, as long as these programs are not provided as part of a clinical
trial.

7.4 Able to read and comprehend English. Eligibility is restricted to individuals who can
comprehend and read English given that participation in the study will require the ability
to read lifestyle intervention materials and communicate with a coach through 42 phone
calls over 2 years. The study team plans to make the intervention available in Spanish in
the future.
We found this trial at
1323
sites
Pittsburgh, Pennsylvania 15232
Principal Investigator: Priscilla F. McAuliffe
Phone: 412-647-8073
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Zoneddy R. Dayao
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Principal Investigator: Thomas H. Openshaw
Phone: 207-626-4855
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
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8600 Old Georgetown Road
Bethesda, Maryland 20814
301-896-3100
Principal Investigator: Vered Stearns
Phone: 301-896-2719
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
(484) 884-2200
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Jennifer A. Ligibel
Phone: 617-667-9925
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Bremerton, Washington 98310
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Tracey L. O'Connor
Phone: 800-767-9355
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Principal Investigator: Jeffrey P. Lamont
Phone: 800-422-9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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3300 Gallows Road
Falls Church, Virginia 22042
(703) 776-4001
Principal Investigator: Kathleen K. Harnden
Phone: 703-208-6650
Inova Fairfax Hospital Inova Fairfax Hospital, Inova's flagship hospital, is an 833-bed, nationally recognized regional...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 771-8000
Principal Investigator: Michael A. Schwartz
Phone: 305-674-2625
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Barbara S. Craft
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Arash Asher
Phone: 310-423-8965
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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777 Hemlock Street
Macon, Georgia 31201
(478) 633-1000
Principal Investigator: Bradley T. Sumrall
Phone: 478-633-2152
Medical Center of Central Georgia Navicent Health is a designated Level I Trauma Center and...
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Alison K. Conlin
Phone: 503-215-2614
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Mary Anne Fenton
Phone: 401-444-1488
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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401 College Street
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Mary H. Hackney
Phone: 773-702-9171
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Richard L. Crownover
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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34800 Bob Wilson Dr,
San Diego, California 92134
(619) 532-6400
Principal Investigator: Preston S. Gable
Phone: 619-532-8712
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
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Seattle, Washington 98104
Principal Investigator: Alison K. Conlin
Phone: 206-215-3086
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1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
Principal Investigator: Julie R. Gralow
Phone: 800-804-8824
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Principal Investigator: Julie R. Gralow
Phone: 800-804-8824
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Principal Investigator: Amy K. Krie
Phone: 888-634-7268
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
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1000 36th Street
Vero Beach, Florida 32960
Principal Investigator: James M. Grichnik
Phone: 772-563-4673
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808 North 39th Avenue
Yakima, Washington 98902
Principal Investigator: John A. Keech
Phone: 509-574-3535
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-487-7447
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-486-6000
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2226 Liliha Street
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-678-9000
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-539-2273
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Abbotsford, British Columbia
Principal Investigator: Thao P. Nguyen
Phone: 604-851-4710
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Aberdeen, South Dakota 57401
Principal Investigator: Amy K. Krie
Phone: 605-622-8700
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Aberdeen, Washington 98520
Principal Investigator: Alison K. Conlin
Phone: 360-412-8958
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Abilene, Texas 79601
Principal Investigator: Ke Ning
Phone: 325-670-6340
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1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Willard G. Andrews
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Adrian, Michigan 49221
Principal Investigator: Rex B. Mowat
Phone: 517-265-0116
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Akron, Ohio 44304
Principal Investigator: Bradley T. Clifford
Phone: 330-375-6101
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1 Akron General Avenue
Akron, Ohio 44307
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Albany, Georgia 31701
Principal Investigator: Sharad A. Ghamande
Phone: 229-312-0405
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315 South Manning Boulevard
Albany, New York 12208
Principal Investigator: Ami Negandhi
Phone: 888-823-5923
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Albert Lea, Minnesota 56007
Principal Investigator: Kathryn J. Ruddy
Phone: 855-776-0015
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Albuquerque, New Mexico 87102
Principal Investigator: Zoneddy R. Dayao
Phone: 505-272-0530
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Albuquerque, New Mexico 87110
Principal Investigator: Zoneddy R. Dayao
Phone: 505-559-6113
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Albuquerque, New Mexico 87102
Principal Investigator: Zoneddy R. Dayao
Phone: 505-272-0530
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Albuquerque, New Mexico 87109
Principal Investigator: Zoneddy R. Dayao
Phone: 773-702-9171
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Alexandria, Louisiana 71301
Principal Investigator: John T. Cole
Phone: 318-448-6976
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Allentown, Pennsylvania 18103
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Amarillo, Texas 79106
Principal Investigator: Brian T. Pruitt
Phone: 806-212-1985
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-956-4132
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-956-4132
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Anacortes, Washington 98221
Principal Investigator: Alison K. Conlin
Phone: 503-215-2614
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Anaheim, California 92806
Principal Investigator: Jonathan A. Polikoff
Phone: 800-398-3996
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Anchorage, Alaska 98508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99504
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 773-702-9171
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: Leander I. Cannick
Phone: 864-512-4651
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Anne F. Schott
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Annapolis, Maryland 21401
Principal Investigator: Mary E. Young
Phone: 443-481-1320
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Antigo, Wisconsin 54409
Principal Investigator: Harish G. Ahuja
Phone: 715-623-9869
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Antioch, California 94531
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
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Appleton, Wisconsin 54911
Principal Investigator: Shannon Schmidt
Phone: 844-510-3600
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Appleton, Wisconsin 54913
Principal Investigator: William A. Conkright
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Arlington Heights, Illinois 60005
Principal Investigator: Stephen S. Nigh
Phone: 847-618-4968
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921 North Oak Park Boulevard
Arroyo Grande, California 93420
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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Arroyo Grande, CA
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364 White Oak St
Asheboro, North Carolina 27203
(336) 625-5151
Principal Investigator: Vinay K. Gudena
Phone: 336-832-0836
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
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Asheboro, NC
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Asheville, North Carolina 28803
Principal Investigator: Raymond Thertulien
Phone: 828-650-8037
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Asheville, NC
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1625 Maple Lane
Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Ashland, WI
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Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Ashland, WI
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Cheryl F. Jones
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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20 Glenlake Parkway Northeast
Atlanta, Georgia 30328
Principal Investigator: Hima B. Lingam
Phone: 800-611-1811
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Atlanta, GA
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Sarah C. Friend
Phone: 888-946-7447
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, Georgia 30322
Principal Investigator: Sarah C. Friend
Phone: 404-778-1868
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Atlanta, GA
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Atlanta, Georgia 30342
Principal Investigator: Sarah C. Friend
Phone: 888-823-5923
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Atlanta, GA
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Atlantis, Florida 33462
Principal Investigator: Georges F. Hatoum
Phone: 561-964-2662
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Atlantis, FL
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Auburn, California 95602
Principal Investigator: Oleg I. Krijanovski
Phone: 415-209-2686
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Auburn, California 95603
Principal Investigator: Oleg I. Krijanovski
Phone: 415-209-2686
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Auburn, New York 13021
Principal Investigator: Jeffrey J. Kirshner
Phone: 315-472-7504
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Auburn, NY
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-887-9333
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Auburn, WA
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Augusta, Georgia 30912
Principal Investigator: Sharad A. Ghamande
Phone: 706-721-2388
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Augusta, GA
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Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Aurora, CO
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1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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Aurora, CO
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12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Regina J. Brown
Phone: 720-848-0650
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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2000 Ogden Ave
Aurora, Illinois 60504
(630) 978-6200
Principal Investigator: Kendrith M. Rowland
Phone: 630-978-6212
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
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Aurora, IL
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1500 Red River Street
Austin, Texas 78701
Principal Investigator: Boone W. Goodgame
Phone: 512-324-7991
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Austin, TX
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Aventura, Florida 33180
Principal Investigator: Michael A. Schwartz
Phone: 305-674-2625
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Aventura, FL
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Bainbridge Island, Washington 98110
Principal Investigator: John A. Keech
Phone: 206-342-6954
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Bainbridge Island, WA
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3325 Pocahontas Road
Baker City, Oregon 97814
Principal Investigator: Benjamin T. Marchello
Phone: 734-712-3671
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Baker City, OR
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Bakersfield, California 93301
Principal Investigator: Scott D. Christensen
Phone: 661-323-4673
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Bakersfield, CA
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Baldwin Park, California 91706
Principal Investigator: Jonathan A. Polikoff
Phone: 800-398-3996
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Ballwin, Missouri 63011
Principal Investigator: Jay W. Carlson
Phone: 314-251-7058
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Ballwin, MO
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Baltimore, Maryland 21237
Principal Investigator: Asma A. Dilawari
Phone: 443-777-7364
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