MMRF Molecular Profiling Protocol
| Status: | Recruiting |
|---|---|
| Conditions: | Blood Cancer, Hematology, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/21/2019 |
| Start Date: | June 2015 |
| End Date: | June 2023 |
| Contact: | Jennifer Yesil, M.S. |
| Email: | yesilj@themmrf.org |
| Phone: | 203.652.0237 |
Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies
Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative
analysis between multiple myeloma or related plasma cell malignancies and normal cells
coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of
the genetic alterations for the purpose of identifying informative and/or actionable
mutations in patients with multiple myeloma and plasma cell malignancies. The approach will
enable the detection of point mutations, insertions/deletions, gene fusions and
rearrangements, amplifications/deletions, and outlier expressed genes among other classes of
alterations.
analysis between multiple myeloma or related plasma cell malignancies and normal cells
coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of
the genetic alterations for the purpose of identifying informative and/or actionable
mutations in patients with multiple myeloma and plasma cell malignancies. The approach will
enable the detection of point mutations, insertions/deletions, gene fusions and
rearrangements, amplifications/deletions, and outlier expressed genes among other classes of
alterations.
Inclusion Criteria:
1. Patients must have a diagnosis of multiple myeloma or related malignancy
2. Patients are undergoing standard of care bone marrow aspirates
3. Patients (male or female) from any race or ethnicity must be at least 18 years of age
at the time of registration.
4. Procedure-specific signed informed consent form prior to initiation of any
study-related procedures.
Exclusion Criteria:
1. It is the enrolling study physician's discretion to decide if a patient is not fit
enough to undergo a bone marrow aspirate.
2. Patients who are incarcerated are not eligible to participate.
3. Women who are pregnant
4. Patients who have had another malignancy within the last five (5) years (except for
basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a
possibility to contaminate the bone marrow aspirate.
We found this trial at
20
sites
University of Chicago One of the world's premier academic and research institutions, the University of...
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Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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University of Michigan The University of Michigan was founded in 1817 as one of the...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Baylor Research Institute Baylor Research Institute (BRI) is a dedicated research center for finding prevention...
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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3322 West End Avenue
Nashville, Tennessee 37203
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
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Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
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