Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage



Status:Terminated
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 75
Updated:7/27/2018
Start Date:July 2016
End Date:June 2018

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Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage

This study compares EG-1962 to enteral nimodipine in the treatment of aneurysmal subarachnoid
hemorrhage.


Inclusion Criteria:

1. Ruptured saccular aneurysm confirmed by angiography and repaired by neurosurgical
clipping or endovascular coiling

2. External ventricular drain in place

3. Subarachnoid hemorrhage on computed tomography (CT) scan of grade 2-4 on the modified
Fisher scale

4. WFNS grade 2, 3, or 4

Exclusion Criteria:

1. Major complication during aneurysm repair such as, but not limited to, massive
intraoperative hemorrhage, brain swelling, arterial occlusion or inability to secure
the ruptured aneurysm

2. Angiographic vasospasm prior to randomization

3. Evidence of a cerebral infarction with neurological deficit
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