ACT-293987 in Pulmonary Arterial Hypertension



Status:Active, not recruiting
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:1/25/2019
Start Date:December 1, 2009
End Date:February 1, 2021

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Trial Summary
Trial Overview
Inclusion Criteria

Long-term Single-arm Open-label Study, to Assess the Safety and Tolerability of Selexipag (ACT-293987) in Patients With Pulmonary Arterial Hypertension

Long-term, single-arm, multicenter, open-label extension, Phase 3 study, to evaluate the
safety and tolerability of ACT-293987 in patients with PAH who participated in the
double-blind study AC-065A302 (GRIPHON)


Inclusion Criteria:

- Patients who participated to the double-blind study AC-065A302 and either had a
morbidity event or had completed the study as scheduled per protocol.

- Signed informed consent.

Exclusion Criteria:

- Patients who have started receiving prostacyclin (epoprostenol) or prostacyclin
analogs (i.e., treprostinil, iloprost, beraprost) since the last study drug intake in
AC-065A302/GRIPHON.

- Severe hepatic impairment (Child-Pugh C).

- Females who are pregnant or who plan to become pregnant during the study, or are
breastfeeding.

- Any known factor or disease that might interfere with treatment compliance, study
conduct or interpretation of the results, such as drug or alcohol dependence, or
psychiatric disease.
We found this trial at
36
sites
University of California, Davis, UC Davis Medical Center
Sacramento, California 95817
363
mi
from 91732
Sacramento, CA
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Tufts Medical Center
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
2578
mi
from 91732
Boston, MA
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Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
13
mi
from 91732
Los Angeles, CA
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University of Michigan
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
1932
mi
from 91732
Ann Arbor, MI
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Emory University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
Atlanta, Georgia 30322
?
mi
from 91732
Atlanta, GA
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Georgia Regents Univ/ Augusta Univ
1430 John Wesley Gilbert Drive
Augusta, Georgia 30912
2058
mi
from 91732
Augusta, GA
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Piedmont Healthcare Pulm & Crit Care Research
3820 Medical Park Drive Southwest
Austell, Georgia 30106
1905
mi
from 91732
Austell, GA
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Johns Hopkins University School of Medicine
733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
Johns Hopkins University School of Medicine Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is...
2302
mi
from 91732
Baltimore, MD
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Boston University School of Medicine / Boston University Medical Center
Boston, Massachusetts 02118
2578
mi
from 91732
Boston, MA
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Montefiore Medical Center-Weiler Division
Bronx, New York 10461
2440
mi
from 91732
Bronx, NY
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Centro de Investigacion y Prevencion Cardiovascular (CIPREC)
Buenos Aires,
6113
mi
from 91732
Buenos Aires,
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The Lindner Clinical Trial Center
Cincinnati, Ohio 45219
1879
mi
from 91732
Cincinnati, OH
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Ohio State University Medical Center
Columbus, Ohio 43210
1959
mi
from 91732
Columbus, OH
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UT Southwestern Medical Center at Dallas
Dallas, Texas 75390
1225
mi
from 91732
Dallas, TX
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Henry Ford Hospital
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
1965
mi
from 91732
Detroit, MI
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
2203
mi
from 91732
Durham, NC
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University of Texas-Houston Health Center Department of Pulmonary & Critical Care
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Baylor College of Medicine, Houston Methodist Hospital
6550 Fannin Street
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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University of California San Diego Medical Center (La Jolla)
La Jolla, California 92037
95
mi
from 91732
La Jolla, CA
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GLVA Healthcare Center
Los Angeles, California 90073
?
mi
from 91732
Los Angeles, CA
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Kentuckiana Pulmonary Associates
Louisville, Kentucky 40202
1813
mi
from 91732
Louisville, KY
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University of Wisconsin Hospital-Department of Medicine
Madison, Wisconsin 53792
1654
mi
from 91732
Madison, WI
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St. Luke's Medical Center
Milwaukee, Wisconsin 53215
1726
mi
from 91732
Milwaukee, WI
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Froedtert Hospital, Pulm & Critical Care
9200 West Wisconsin Avenue
Milwaukee, Wisconsin 53226
1723
mi
from 91732
Milwaukee, WI
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Vanderbilt Medical Center
Nashville, Tennessee 37212
1762
mi
from 91732
Nashville, TN
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LSU Health Science Center - New Orleans
New Orleans, Louisiana 70112
1655
mi
from 91732
New Orleans, LA
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Columbia University Medical Center, Pediatric Cardiology
New York, New York 10032
2435
mi
from 91732
New York, NY
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Christiana Care Health Services, Inc
Newark, Delaware 19713
2347
mi
from 91732
Newark, DE
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Newark Beth Israel Medical Center
201 Lyons Ave
Newark, New Jersey 07112
(973) 926-7000
Newark Beth Israel Medical Center Newark Beth Israel Medical Center, a regional care, teaching hospital...
2423
mi
from 91732
Newark, NJ
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
2375
mi
from 91732
Philadelphia, PA
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Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
2375
mi
from 91732
Philadelphia, PA
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Oregon Pulmonary Associates, PC
Portland, Oregon 97225
?
mi
from 91732
Portland, OR
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1569
mi
from 91732
Saint Louis, MO
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LIU Center for Pulmonary Hypertension
Torrance, California 90502
24
mi
from 91732
Torrance, CA
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William Beaumont Hospital
Troy, Michigan 48085
1965
mi
from 91732
Troy, MI
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University of Arizona Clinical and Translational Science (CATS) Research Center
Tucson, Arizona 85724
427
mi
from 91732
Tucson, AZ
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