Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:August 18, 2014

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Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

This phase III ALCHEMIST trial studies genetic testing in screening patients with stage
IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the
genes in a patient's tumor cells may help doctors select the best treatment for patients that
have certain genetic changes.

PRIMARY OBJECTIVES:

I. To centrally test resected non-small cell lung cancer (NSCLC) for genetic mutations to
facilitate accrual to randomized adjuvant studies.

II. To obtain clinically annotated tumor tissue and patient-matched non-malignant
deoxyribonucleic acid (DNA) from peripheral blood, as well as detailed epidemiologic and
clinical follow-up data, to allow clinically annotated advanced genomic analyses in concert
with the National Cancer Institute (NCI) Center for Cancer Genomics (CCG).

SECONDARY OBJECTIVES:

I. To characterize the natural history of molecularly characterized NSCLC to allow subsequent
development of targeted therapies against genotype-defined subpopulations in the adjuvant and
recurrent settings.

II. To cross-validate local genotyping assays for epidermal growth factor receptor (EGFR) and
anaplastic lymphoma receptor tyrosine kinase (ALK) with a central reference standard.

EXPLORATORY OBJECTIVES:

I. To study the genomic evolution of lung cancers by comparing genomic characteristics at
resection and at recurrence.

II. To understand reasons behind lack of enrollment to adjuvant targeted therapy studies for
potentially eligible patients.

III. To study the clinical significance of circulating tumor DNA within the plasma cell-free
DNA (cfDNA) from early stage lung cancer patients.

OUTLINE:

STEP 1 (SCREENING): Patients undergo collection of blood and tissue samples for EGFR, ALK,
and programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1)/cytotoxic
t-lymphocyte-associated protein 4 (CTLA-4) testing via direct sequencing, fluorescence in
situ hybridization (FISH) and immunohistochemistry (IHC). Patients that have had surgery
prior to pre-registration will submit samples from the previous surgery for testing.

STEP 2 (TREATMENT): Patients with a mutation targeted by one or more of the investigational
drugs used in this study or those without mutations are assigned to 1 of 3 treatment
subprotocols.

A081105: Patients are randomized to 1 of 4 treatment arms.

ARM A (BLINDED ERLOTINIB- CLOSED 06/14/17): Blinded patients receive erlotinib hydrochloride
orally (PO) once daily (QD) on days 1-21. Treatment repeats every 21 days for up to 2 years
in the absence of disease progression or unacceptable toxicity.

ARM B (PLACEBO- CLOSED 06/14/17): Patients receive placebo PO QD on days 1-21. Treatment
repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable
toxicity.

ARM C (UNBLINDED ERLOTINIB): Unblinded patients receive erlotinib hydrochloride PO QD on days
1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression
or unacceptable toxicity.

ARM D (OBSERVATION): Patients (including patients previously randomized to placebo) undergo
observation at least every 6 months for 2 years.

E4512: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive crizotinib PO twice daily (BID) on days 1-21. Treatment repeats every
21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

ARM B: Patients undergo observation.

EA5142: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1. Courses repeat
every 4 weeks for up to 1 year in the absence of disease progression or unacceptable
toxicity.

ARM II: Patients are followed serially with imaging for 1 year.

After completion of study, patients that are not enrolled on either A081105, E4512, or EA5142
are followed up every 6 months for 5 years.

Inclusion Criteria:

- PATIENT PRE-REGISTRATION ELIGIBILITY CRITERIA:

- For pre-surgical patients

- Suspected diagnosis of resectable non-small cell lung cancer; cancers with a
histology of "adenosquamous" are considered a type of adenocarcinoma and thus a
"nonsquamous" histology; patients with squamous cell carcinoma are eligible only
if the registering site has EA5142 Institutional Review Board (IRB) approved

- Suspected clinical stage of IIIA, II (IIA or IIB) or large IB (defined as size >=
4 cm); Note: IB tumors < 4 cm are NOT eligible; stage IB cancer based on pleural
invasion is not eligible unless the tumor size is >= 4 cm; the 7th edition of
American Joint Committee on Cancer (AJCC) staging will be utilized

- For post-surgical patients

- Completely resected non-small cell lung cancer with negative margins (R0);
patients with squamous cell carcinoma are eligible only if the registering site
has EA5142 IRB approved

- Pathologic stage IIIA, II (IIA or IIB) or large IB (defined as size >= 4 cm);
Note: IB tumors < 4 cm are NOT eligible; stage IB cancer based on pleural
invasion is not eligible unless the tumor size is >= 4 cm; the 7th edition of
AJCC staging will be utilized

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- No patients who have received neoadjuvant therapy (chemo- or radio-therapy) for this
lung cancer

- No locally advanced or metastatic cancer requiring systemic therapy within 5 years
prior to registration; no secondary primary lung cancer diagnosed concurrently or
within 2 year prior to registration

- No prior treatment with agents targeting EGFR mutation, ALK rearrangement, and
PD-1/PD-L1/CTLA-4

- No patients known to be pregnant or lactating

- Patients who have had local genotyping are eligible, regardless of the local result

- No patients with recurrence of lung cancer after prior resection

- Note: Post-surgical patients should proceed to registration immediately following
preregistration

- PATIENT REGISTRATION ELIGIBILITY CRITERIA:

- Completely resected NSCLC with negative margins (R0); cancers with a histology of
"adenosquamous" are considered a type of adenocarcinoma and thus a "nonsquamous"
histology; patients with squamous cell carcinoma are eligible only if the registering
site has EA5142 IRB approved

- Pathologic stage IIIA, IIA or IIB, or large IB (defined as size >= 4 cm); Note: IB
tumors < 4 cm are NOT eligible; stage IB cancer based on pleural invasion is not
eligible unless the tumor size is >= 4 cm; the 7th edition of AJCC staging will be
utilized

- Tissue available for the required analyses (either clinical tissue block or slides and
scrolls)

- In order to allow for time for central genotyping and eligibility for the ALCHEMIST
treatment trial, patients must register within the following eligibility windows,
depending on the adjuvant treatment approach:

- If no adjuvant therapy, register patient within 75 days following surgery

- If adjuvant chemotherapy or radiotherapy only, register patient within 225 days
following surgery

- If adjuvant chemotherapy and radiation, register patient within 285 days
following surgery
We found this trial at
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Munster, Indiana 46321
Principal Investigator: Mohamad Kassar
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1201 Camino de Salud Northeast
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361 Old Belgrade Road
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Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
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75 Francis street
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330 Brookline Ave
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666 Elm Street
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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1 South Prospect Street
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1300 Jefferson Park Avenue
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1500 E Duarte Rd
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4725 North Federal Highway
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593 Eddy Street
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401 College Street
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60 Crittenden Blvd # 70
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34800 Bob Wilson Dr,
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1100 Fairview Avenue North
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3900 W Avera Drive
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601 South Sherman Street
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Albuquerque, New Mexico 87102
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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Anchorage, Alaska 99508
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2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
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5301 McAuley Drive
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734-712-3456
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Principal Investigator: Matthias Weiss
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Appleton, Wisconsin 54911
Principal Investigator: Matthias Weiss
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Appleton, Wisconsin 54911
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1506 South Oneida Street
Appleton, Wisconsin 54915
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921 North Oak Park Boulevard
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364 White Oak St
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(336) 625-5151
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Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
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Asheville, North Carolina 28801
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Asheville, North Carolina 28801
Principal Investigator: Christopher H. Chay
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Asheville, North Carolina 28803
Principal Investigator: Raymond Thertulien
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Ashland, Kentucky 41101
Principal Investigator: David K. Goebel
Phone: 888-823-5923
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1625 Maple Lane
Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Ashland, WI
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Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Ashland, WI
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Athens, Georgia 30607
Principal Investigator: Sharad A. Ghamande
Phone: 706-353-5006
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Athens, GA
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Taofeek K. Owonikoko
Phone: 888-946-7447
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, GA
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Sreekanth C. Reddy
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Atlanta, Georgia 30322
Principal Investigator: Taofeek K. Owonikoko
Phone: 404-778-1868
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Atlanta, Georgia 30342
Principal Investigator: Taofeek K. Owonikoko
Phone: 888-823-5923
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Auburn, California 95602
Principal Investigator: Edmund W. Tai
Phone: 415-209-2686
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Auburn, CA
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Auburn, California 95603
Principal Investigator: Edmund W. Tai
Phone: 415-209-2686
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-887-9333
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Auburn, WA
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Augusta, Georgia 30912
Principal Investigator: Sharad A. Ghamande
Phone: 706-721-2388
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Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Aurora, CO
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1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Jose M. Pacheco
Phone: 720-848-0650
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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