A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain



Status:Terminated
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:40 - 75
Updated:11/10/2018
Start Date:July 2014
End Date:June 2015

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A Phase 2, Randomized, Double-Blind, Placebo and Active-Controlled Trial of LY2951742 in Patients With Mild to Moderate Osteoarthritis Pain of the Knee

The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain.
The study drugs will be given as an injection under the skin and as an oral capsule. The
study will last about 28 weeks for each participant.


Inclusion Criteria:

- Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology
(ACR) criteria and confirmed with X-rays and ACR functional class of I to III

- Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs
(NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at
least 20 days in the past month

- Willing to stop all analgesics for OA pain during the study

- Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100
Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm
following washout of current Osteoarthritis pain medications at screening

Exclusion Criteria:

- Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs

- Arthritis of the knee from other causes

- Uncontrolled hypertension

- Have OA pain that requires treatment with potent opioids, systemic corticosteroids,
intra-articular injections, duloxetine, or venlafaxine

- Moderate to severe renal impairment

- Pregnant or lactating
We found this trial at
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San Diego, California 92123
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2017 Canyon Road, Suite 41
Birmingham, Alabama 35216
(205) 757-8208
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860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
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4495 Hale Parkway
Denver, Colorado 80220
303-399-4067
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900 W 49th St # 430
Hialeah, Florida 33012
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400 Tower Rd Ne
Marietta, Georgia 30060
678-581-5252
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400 Gresham Dr
Norfolk, Virginia 23507
757-627-7446
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104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
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100 West Gore St # 202
Orlando, Florida 32806
(407) 426-9299
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Albuquerque, NM
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760 North Euclid Street
Anaheim, California 92801
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Biloxi, Mississippi 39531
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Brockton, Massachusetts 02301
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Charleston, South Carolina 29406
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Chicago, Illinois 60603
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Duncansville, Pennsylvania 16635
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Gainesville, Georgia 30501
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Greensboro, North Carolina 27408
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Greenville, South Carolina 29601
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Hartsdale, New York 10530
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Hialeah, Florida 33012
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Methuen, Massachusetts 01844
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Miami, Florida 33155
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286 Westward Drive
Miami, Florida 33185
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Nassau Bay, Texas 77058
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New York, New York 10004
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Newport News, Virginia 23606
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San Antonio, Texas 78209
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Upland, California 91786
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55 University Drive
Valparaiso, Indiana 46383
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Walnut creek, California 94598
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Warwick, Rhode Island 02888
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West Covina, California 91760
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Williamsville, New York 14221
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Wooster, Ohio 44691
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