Interventional Management of Stroke (IMS) III Trial



Status:Archived
Conditions:Peripheral Vascular Disease, Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:Any
Updated:7/1/2011

Use our guide to learn which trials are right for you!

Interventional Management of Stroke Trial: A Phase III Clinical Trial Examining Whether a Combined Intravenous (IV) and Intra-Arterial (IA) Approach to Recanalization is Superior to Standard IV Rt-PA (Activase®) Alone When Initiated Within Three Hours of Acute Ischemic Stroke Onset


The purpose of this study is to compare two different treatment approaches—combined
intravenous and intra-arterial treatment including recombinant tissue plasminogen activator
(rt-PA) and standard intravenous (IV) rt-PA—to restoring blood flow to the brain.


Stroke remains a major cause of death and disability. Acute thrombolytic therapy offers the
potential to achieve early recanalization (reopening of blocked arteries), save tissues, and
improve outcome. Currently, intravenous (IV) recombinant tissue plasminogen activator
(rt-PA) is the only approved acute stroke therapy. IV rt-PA is an effective therapy for
acute ischemic stroke but has substantial limitations when used alone to open blocked
arteries The Interventional Management of Stroke (IMS III) Trial is a multi-center study
that will compare two different treatment approaches for restoring blood flow to the brain.
One approach, giving the clot-dissolving drug rt-PA, is already FDA-approved when given
through a vein (IV). This treatment will be compared to a new approach, giving rt-PA at a
lower dose first through IV in the arm and then, if a blood clot in the brain artery is
found, through a small tube or catheter at the site of the blood clot (intra-arterial or IA)
to see which is better. Both approaches must be initiated within three hours of stroke
onset.

The primary goal of this trial is to determine if individuals with ischemic stroke treated
with rt-PA using a combined IV/IA approach to recanalization started within 3 hours of onset
are more likely to have a better outcome than individuals treated with standard IV rt-PA
alone.

Nine hundred participants with moderate to severe ischemic stroke will be enrolled at more
than 50 centers in the United States, Canada, and Australia. Participants will be assigned
randomly to one of 2 groups. Two participants will be randomized to the combined approach
for every one participant randomized to standard IV rt-PA. Group one will receive the
standard dose of IV rt-PA given over an hour. Group two will receive the standard dose of
IV rt-PA for only 40 minutes and then undergo an angiogram test (cerebral angiography) right
after the medicine is given to check for blood clots. If a clot is not seen then no more
treatment will be given. If a clot is seen, the doctor (a neurointerventionalist) will then
choose, based on the location and extent of the blood clot, one of 4 possible IA treatments
given directly in the brain artery that will be most effective in reopening the blocked
artery. All of the IA treatments used—embolectomy therapy with either the Merci® Retriever
or The Penumbra System™, or rt-PA infusion through the EKOS® Micro-Infusion Catheter,
concurrent with delivery of low-intensity ultrasound energy, or infusion of rt-PA though a
standard microcatheter at the site of the blood clot in the brain artery.

The primary measure of benefit in this trial is the ability of the individual with stroke to
live and function independently 3 months after the stroke. This trial will also determine
and compare the safety and cost effectiveness of the combined IV/IA approach to the standard
IV rt-PA approach.

Duration of the study for participants is approximately 12 months.


We found this trial at
50
sites
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
300 Pinellas St.
Clearwater, Florida 33756
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
?
mi
from
Houston, TX
Click here to add this to my saved trials
Sarasota, Florida 34232
?
mi
from
Sarasota, FL
Click here to add this to my saved trials
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Asheville, North Carolina 28801
?
mi
from
Asheville, NC
Click here to add this to my saved trials
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston, Massachusetts 02135
?
mi
from
Boston, MA
Click here to add this to my saved trials
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
Burlington, Maine 01805
?
mi
from
Burlington, ME
Click here to add this to my saved trials
101 Manning Dr
Chapel Hill, North Carolina 27599
(919) 966-4131
University of North Carolina Hospital at Chapel Hill The UNC Health Care System is a...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlottesville, Virginia 22903
(434) 924-0311
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Cincinnati, Ohio 45236
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Cincinnati, Ohio 45239
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Cincinnati, Ohio 45238
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
?
mi
from
Columbus, OH
Click here to add this to my saved trials
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
East Lansing, Michigan 48824
?
mi
from
East Lansing, MI
Click here to add this to my saved trials
Elk Grove Village, Illinois 60007
?
mi
from
Elk Grove Village, IL
Click here to add this to my saved trials
?
mi
from
Englewood, CO
Click here to add this to my saved trials
Fairfield, Ohio 45014
?
mi
from
Fairfield, OH
Click here to add this to my saved trials
?
mi
from
Florence, KY
Click here to add this to my saved trials
Ft. Thomas, Kentucky 41075
?
mi
from
Ft. Thomas, KY
Click here to add this to my saved trials
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
?
mi
from
Hershey, PA
Click here to add this to my saved trials
757 Westwood Plaza
Los Angeles, California 90024
(310) 825-9111
UCLA Medical Center Founded in 1955, UCLA Medical Center became Ronald Reagan UCLA Medical Center...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
530 S Jackson St
Louisville, Kentucky 40202
502-562-3226
University of Louisville Hospital As the academic hospital at the heart of the Louisville Metro...
?
mi
from
Louisville, KY
Click here to add this to my saved trials
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
?
mi
from
Miami, FL
Click here to add this to my saved trials
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
?
mi
from
Montgomery, OH
Click here to add this to my saved trials
New Britain, Connecticut 06052
?
mi
from
New Britain, CT
Click here to add this to my saved trials
Newport Beach, California 92663
?
mi
from
Newport Beach, CA
Click here to add this to my saved trials
?
mi
from
Northridge, CA
Click here to add this to my saved trials
Phoenix, Arizona 85054
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Phoenix, Arizona 85013
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15212
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Santa Monica, California 90404
?
mi
from
Santa Monica, CA
Click here to add this to my saved trials
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
St. Louis, Missouri 63110
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
St. Paul, Minnesota 55102
?
mi
from
St. Paul, MN
Click here to add this to my saved trials