HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network



Status:Recruiting
Conditions:Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:6/17/2018
Start Date:November 2011
End Date:December 2018

Use our guide to learn which trials are right for you!

HCV-TARGET: Hepatitis C Therapeutic Registry and Research Network - A Longitudinal, Observational Study.

The primary purpose of the HCV-TARGET study is to establish a nationwide registry of patients
undergoing treatment with antiviral therapies for chronic hepatitis C (HCV) at both academic
and community practices.

HCV-TARGET is a longitudinal, observational study that will create a carefully maintained
research registry of HCV patients treated with antiviral therapies designed to rapidly inform
strategies for better management of populations underrepresented in clinical trials, identify
and remediate educational gaps relative to treatment guidelines and adverse event management
in order to optimize rates of sustained virological response (SVR), and serve as the core
resource for important collaborative translational studies utilizing biospecimens and
clinical data from diverse patient populations.

HCV-TARGET is a cooperative academic consortium of principal investigators from Clinical and
Translational Award (CTSA)-funded academic institutions and community-based sites affiliated
with the academic sites in geographic proximity. The Clinical Coordinating Center (CCC)
resides at the University of Florida and the Data Coordinating Center (DCC) resides at the
University of North Carolina at Chapel Hill.

The HCV-TARGET registry will characterize the population of chronic hepatitis C (HCV)
patients who are being treated with antiviral therapies at academic and community sites.
Patient characteristics such as age, race, ethnicity, comorbidity, and disease and treatment
status will be examined.

HCV-TARGET will also:

1. Provide baseline and treatment response data that will be used to pre-identify
candidates for enrollment in future clinical trials. HCV-TARGET will also develop a
well-characterized cohort of protease inhibitor treatment failures to be considered for
future trials.

2. Establish and maintain data, a specimen bank and other resources for ancillary studies
of the pathogenesis, diagnosis, natural history and treatment of HCV infection.

This study will investigate various aspects of treatment response to regimens containing
direct-acting antiviral agents for the treatment of chronic hepatitis C, including the
following:

- Patients underrepresented in clinical trials of approved antiviral therapies(including
African-Americans, patients with cirrhosis, and patients that are considered null
responders to treatment.)

- Treatment persistence

- Virological breakthrough

- Impact of viral load measurement on treatment efficacy

- Adverse Event Management and Surveillance.

The secondary aims for this study will investigate the following:

- Sustained virological response (SVR) rates and safety in special populations.

- Surveillance of drug-drug interactions.

- Treatment and management adherence.

- Pretreatment Education in HCV patient population.

- Use of specialty pharmacy for hepatitis C therapy.

Inclusion Criteria:

- All adult patients (age 18 or older) being treated with antiviral HCV treatment
regimens that contain telaprevir or boceprevir.

Exclusion Criteria:

- Inability to provide written informed consent.

- Currently participating in another clinical trial of hepatitis C therapeutics. Studies
comparing HCV RNA assays are not considered exclusionary.
We found this trial at
53
sites
New York, New York 10021
Principal Investigator: Robert S Brown, MD
Phone: 646-962-4742
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Michael W. Fried, M.D
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Nancy Reau, MD
Phone: 773-702-4477
University of Chicago One of the world's premier academic and research institutions, the University of...
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3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Principal Investigator: Jacqueline O'Leary, MD
Phone: 214-820-6243
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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Gainesville, Florida 32610
(352) 392-3261
Principal Investigator: Giuseppe Morelli, M.D.
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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1601 Northwest 12th Avenue
Miami, Florida 33136
(305) 243-6545
Principal Investigator: Eugene Schiff, MD
Phone: 305-243-0311
University of Miami Miller School of Medicine The University of Miami Leonard M. Miller School...
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Mohamed Hassan, MD
Phone: 612-626-1716
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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Seattle, Washington 98104
(206) 543-2100
Principal Investigator: Charles Landis, MD
Phone: 206-744-3402
Univ of Washington Founded in 1861 by a private gift of 10 acres in what...
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Anna SF Lok, MD
Phone: 734-647-0236
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Asheville, North Carolina 28801
Principal Investigator: Will Harlan, MD
Phone: 828-350-3669
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Atlanta, Georgia 30312
Principal Investigator: Brian Pearlman, MD
Phone: 404-265-1044
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Austin, Texas 78758
Principal Investigator: Imtiaz Alam, MD
Phone: 512-371-7702
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Austin, Texas 78758
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Beacon, New York 12508
Principal Investigator: Christine Kerr, MD
Phone: 914-419-3150
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Boston, Massachusetts 02114
Principal Investigator: Raymond Chung, MD
Phone: 617-724-3836
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Boston, Massachusetts 02215
Principal Investigator: Michael Curry, MD
Phone: 617-632-1129
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303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Josh Levitsky, MD
Phone: 312-926-0370
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2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
Principal Investigator: Kenneth Sherman, MD
Phone: 513-584-2363
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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Denver, Colorado 80291
Principal Investigator: James Burton, MD
Phone: 303-724-1861
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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Principal Investigator: Stuart C Gordon, MD
Phone: 313-916-1962
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Anrdrew Muir, MD
Phone: 919-681-2941
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Houston, Texas 77030
Principal Investigator: Joseph Galati, MD
Phone: 713-634-5110
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545 Barnhill Dr
Indianapolis, Indiana 46201
(317) 274-8157
Principal Investigator: Marco Lacerda, MD
Phone: 317-278-4633
Indiana University Medical Center Indiana University Health is Indiana
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La Jolla, California 92037
Principal Investigator: Paul Pockros, MD
Phone: 858-652-5419
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Principal Investigator: Rolland C Dickson, MD
Phone: 603-653-3668
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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Little Rock, Arkansas 72205
Principal Investigator: Alonzo Williams, MD
Phone: 501-687-9300
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Lutherville, Maryland 21218
Principal Investigator: Mark Sulkowski, MD
Phone: 443-287-9605
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Minneapolis, Minnesota 55455
Principal Investigator: Coleman Smith, MD
Phone: 612-625-0673
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New Haven, Connecticut 06520
Principal Investigator: Joseph Lim, MD
Phone: 203-737-6839
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630 W 168th St
New York, New York
212-305-2862
Principal Investigator: Elizabeth Verna, MD
Phone: 212-305-3839
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Emile St
Omaha, Nebraska 68198
(402) 559-4000
Principal Investigator: Mark Mailliard, MD
Phone: 402-559-3652
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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1701 North Mills Avenue
Orlando, Florida 32803
(407)647-3960
Principal Investigator: Edwin DeJesus, MD
Phone: 480-342-1328
Orlando Immunology Center Orlando Immunology Center , or simply (OIC) is a part of Infectious...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Rajender Reddy, MD
Phone: 215-615-5471
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Jonathan Fenkel, MD
Phone: 215-955-8108
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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Phoenix, Arizona 85054
Principal Investigator: Hugo Vargas, MD
Phone: 480-342-1328
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Richmond, Virginia 23226
Principal Investigator: Mitchell L. Shiffman, MD
Phone: 804-977-8921
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Richmond, Virginia 23298
Principal Investigator: Richard K Sterling, MD
Phone: 804-828-2202
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Rochester, Minnesota 55905
Principal Investigator: Kimberly Watt, MD
Phone: 507-293-4773
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Rocky Mount, North Carolina 27804
Principal Investigator: M Mah'moud
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Saint Louis, Missouri 63110
Principal Investigator: Adrian DiBisceglie, MD
Phone: 314-977-9400
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34800 Bob Wilson Drive
San Diego, California 92103
Principal Investigator: Alexander Kuo, MD
Phone: 619-471-3922
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San Francisco, California 94143
Principal Investigator: Nora Terrault, MD
Phone: 415-514-3274
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1635 Divisadero Street
San Francisco, California 94110
Principal Investigator: Mandana Khalili, MD
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Santa Fe, New Mexico 87505
Principal Investigator: Trevor N Hawkins, MD
Phone: 505-216-1546
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Seattle, Washington 98101
(888) 862-2737
Principal Investigator: James Bredfeldt, MD
Phone: 206-341-1992
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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Toronto, Ontario
Principal Investigator: Jordan Feld, MD
Phone: 416-603-5800 x 5086
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Valatie, New York 12184
Principal Investigator: Anathakrishnan Ramani, MD
Phone: 518-943-1943
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3700 O St NW
Washington, District of Columbia 20057
(202) 687-0100
Principal Investigator: Coleman Smith, MD
Georgetown University Georgetown University is one of the world's leading academic and research institutions, offering...
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Wilmington, North Carolina 28403
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55 N Lake Ave
Worcester, Massachusetts 01655
(508) 856-8989
Principal Investigator: Gyongyi Szabo, MD
Phone: 774-441-7727
Univ of Massachusetts Med School As the commonwealth's only public medical school, we take seriously...
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