Safety and Efficacy of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients



Status:Recruiting
Conditions:Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:Any
Updated:11/11/2012
Start Date:May 2011
Contact:Novartis Pharmaceuticals
Phone:862-778-8300

Use our guide to learn which trials are right for you!

A Randomized, Double-blind, Active-controlled Study of Canakinumab Prefilled Syringes or Reconstituted Lyophilizate Versus Triamcinolone Acetonide for Treating Acute Gouty Arthritis Flares in Frequently Flaring Patients


This study will assess the safety and efficacy of canakinumab pre-filled syringes in
comparison to triamcinolone acetonide 40 mg and canakinumab lyophilizate in patients that
have frequent flares of acute gouty arthritis.


Inclusion criteria:

- 3 or more gout flares within last year

- Contraindication, intolerance or lack of efficacy for NSAIDs and/or colchicine

- Body mass index of less than or equal to 45 kg/m2

Exclusion criteria:

- Use of the following therapies (within varying protocol defined timeframes):
corticosteroids, narcotics, topical ice/cold packs, chronic opiate treatment, NSAIDs
(such as aspirin), colchicine.

- Hemodialysis

- Live vaccine within 3 months before first dose

- Donation or loss of 400 mL or more within 3 months before first dose

- Gout brought on by other factors such as chemotherapy, lead, transplant, etc.

- Presence of other acute inflammatory arthritis such as Rheumatoid Arthritis

- Any conditions or significant medical problems that puts the patient at an
unacceptable immunological risk to receive this type of therapy such as HIV,
Hepatitis, Tuberculosis and other infections/conditions

- Significant cardiovascular conditions such as uncontrolled hypertension

- Significant medical diseases such as uncontrolled diabetes, thyroid disease

- History of malignancy of any organ system within the past 5 years

- Women who are pregnant or nursing

- Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
72
sites
?
mi
from
Augusta, GA
Click here to add this to my saved trials
175 Meadowbrook Lane
, Pennsylvania 16635
814-693-0300
?
mi
from
, PA
Click here to add this to my saved trials
325 Winding River Lane
, Virginia 22911
434-817-2442
?
mi
from
, VA
Click here to add this to my saved trials
1952 - 152nd Place NE
East Seattle, Washington 98007
425-453-0404
?
mi
from
East Seattle, WA
Click here to add this to my saved trials
404 Memorial Dr.
Greer, South Carolina 29651
864-848-9293
?
mi
from
Greer, SC
Click here to add this to my saved trials
1044 SW 44th Street
Oklahoma City, Oklahoma 73109
405-616-4888
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
6600 Mercy Ct Fair Oaks
Sacramento, California 95628
916-966-7452
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
823 SW Mulvane St
Topeka, Kansas 66606
785-368-0741
?
mi
from
Topeka, KS
Click here to add this to my saved trials
1202 Medical Center Dr.
Wilmington, North Carolina 28401
910-815-6108
?
mi
from
Wilmington, NC
Click here to add this to my saved trials
Anniston, Alabama 36207
?
mi
from
Anniston, AL
Click here to add this to my saved trials
Asheville, North Carolina 28803
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Belzoni, Mississippi 39038
?
mi
from
Belzoni, MS
Click here to add this to my saved trials
Boise, Idaho 83702
?
mi
from
Boise, ID
Click here to add this to my saved trials
Bountiful, Utah 84010
?
mi
from
Bountiful, UT
Click here to add this to my saved trials
Bristol, Tennessee 37620
?
mi
from
Bristol, TN
Click here to add this to my saved trials
Buena Park, California
?
mi
from
Buena Park, CA
Click here to add this to my saved trials
Chandler, Arizona 85225
?
mi
from
Chandler, AZ
Click here to add this to my saved trials
Charleston, South Carolina 29412
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlotte, North Carolina 28277
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Charlotte, North Carolina 28209
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Chesapeake, Virginia 23320
?
mi
from
Chesapeake, VA
Click here to add this to my saved trials
Clarksville, Tennessee 37043
?
mi
from
Clarksville, TN
Click here to add this to my saved trials
Clearwater, Florida 33756
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Columbia, South Carolina 29204
?
mi
from
Columbia, SC
Click here to add this to my saved trials
Columbus, Ohio 43212
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Dallas, Texas 75231
?
mi
from
Dallas, TX
Click here to add this to my saved trials
142 S Main St
Danville, Virginia 24541
(434) 799-2100
Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
?
mi
from
Danville, VA
Click here to add this to my saved trials
Decatur, Georgia 30035
?
mi
from
Decatur, GA
Click here to add this to my saved trials
East Point, Georgia 30344
?
mi
from
East Point, GA
Click here to add this to my saved trials
Fargo, North Dakota 58103
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Fayetteville, Tennessee 33734
?
mi
from
Fayetteville, TN
Click here to add this to my saved trials
Foley, Alabama 36535
?
mi
from
Foley, AL
Click here to add this to my saved trials
Fort Mill, South Carolina 29707
?
mi
from
Fort Mill, SC
Click here to add this to my saved trials
Freehold, New Jersey 07728
?
mi
from
Freehold, NJ
Click here to add this to my saved trials
Greensboro, North Carolina 27410
?
mi
from
Greensboro, NC
Click here to add this to my saved trials
Greensboro, North Carolina 27408
?
mi
from
Greensboro, NC
Click here to add this to my saved trials
?
mi
from
Houston, TX
Click here to add this to my saved trials
Jackson, Mississippi 39209
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Jackson, Mississippi 39202
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Johnson City, Tennessee 37601
?
mi
from
Johnson City, TN
Click here to add this to my saved trials
Jupiter, Florida 33458
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
Lake Success, New York 11042
?
mi
from
Lake Success, NY
Click here to add this to my saved trials
Lincoln, Nebraska 68512
?
mi
from
Lincoln, NE
Click here to add this to my saved trials
Louisville, Kentucky 40217
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Memphis, Tennessee 38125
?
mi
from
Memphis, TN
Click here to add this to my saved trials
Metairie, Louisiana 70006
?
mi
from
Metairie, LA
Click here to add this to my saved trials
Midlothian, Virginia 23114
?
mi
from
Midlothian, VA
Click here to add this to my saved trials
259 1st St
Mineola, New York 11501
(516) 663-0333
Winthrop University Hospital Founded in 1896 by a group of local physicians and concerned citizens,...
?
mi
from
Mineola, NY
Click here to add this to my saved trials
Missoula, Montana
?
mi
from
Missoula, MT
Click here to add this to my saved trials
Mobile, Alabama 36608
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Murrells Inlet, South Carolina 29576
?
mi
from
Murrells Inlet, SC
Click here to add this to my saved trials
Newport News, Virginia 23606
?
mi
from
Newport News, VA
Click here to add this to my saved trials
North Richland Hills, Texas 76180
?
mi
from
North Richland Hills, TX
Click here to add this to my saved trials
Norwalk, California 90650
?
mi
from
Norwalk, CA
Click here to add this to my saved trials
10040 Regency Cir
Omaha, Nebraska 68114
(402) 934-0044
Quality Clinical Research, Inc. Welcome to Quality Clinical Research. We originated here in Omaha, NE...
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Omaha, Nebraska 68134
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Omaha, Nebraska 68130
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Overland Park, Kansas 66215
?
mi
from
Overland Park, KS
Click here to add this to my saved trials
Owensboro, Kentucky 42303
?
mi
from
Owensboro, KY
Click here to add this to my saved trials
Picayune, Mississippi 39466
?
mi
from
Picayune, MS
Click here to add this to my saved trials
Pinellas Park, Florida 33782
?
mi
from
Pinellas Park, FL
Click here to add this to my saved trials
Raleigh, North Carolina 27609
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
Roseville, California 95661
?
mi
from
Roseville, CA
Click here to add this to my saved trials
Roslyn, New York 11576
?
mi
from
Roslyn, NY
Click here to add this to my saved trials
Salisbury, North Carolina 28144
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
San Marino, California 91108
?
mi
from
San Marino, CA
Click here to add this to my saved trials
Shelby, North Carolina 28152
?
mi
from
Shelby, NC
Click here to add this to my saved trials
South Miami, Florida 33143
?
mi
from
South Miami, FL
Click here to add this to my saved trials
Troy, Michigan 48085
?
mi
from
Troy, MI
Click here to add this to my saved trials
Tucson, Arizona 85710
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Varnville, South Carolina 29924
?
mi
from
Varnville, SC
Click here to add this to my saved trials
Westlake Village, California 91361
?
mi
from
Westlake Village, CA
Click here to add this to my saved trials