Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting



Status:Active, not recruiting
Conditions:Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:1/25/2018
Start Date:December 2, 2010
End Date:August 30, 2020

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Studying Interventions for Managing Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY)

The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI)
in patients newly diagnosed with CML and their quality of life in a real-world setting.

Time Perspective : Most patients are expected to be a mix of retrospective and prospective
data collection. Patients can be enrolled after their study index date (retrospective
component) and have to be followed until 5 years from study index date are complete (time
between enrollment and 5 year follow-up is the prospective component)

For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com.

Inclusion Criteria:

- Newly-diagnosed chronic phase chronic myeloid leukemia (CP-CML) patients who started
their first-line Tyrosine Kinase Inhibitor (TKI) treatment on imatinib, dasatinib or
nilotinib in accordance with the timelines below

- 18 years or older at time of of CP-CML diagnosis

a) Imatinib Cohorts

- Patients who started their first-line Imatinib treatment between January 2, 2008 and
September 30, 2010.Patients fitting this criterion are defined as retrospective
Imatinib patients

− Patients who started their first-line Imatinib treatment on or after October 1, 2010

b) Dasatinib Cohort

- Patients who started their first-line Dasatinib treatment after the drug was approved
in this indication

c) Nilotinib Cohort

- Patients who started their first-line Nilotinib treatment after the drug was approved
in this indication

- Patients are also eligible when they have already switched to a subsequent therapy
(TKI or other) at the time of enrollment, as long as their first-line and subsequent
CML treatment information is available at site for data entry into the study
Electronic Case Report Form (eCRF)

- Receiving treatment at medical practice (eg. community-based, office-based,
hospital-based, academic setting, oncology center)

Exclusion Criteria:

- Patients who are participating in an interventional trial which may influence the
management of their CML disease will be excluded

Discontinuation Criteria:

- Enrolled patients who join an interventional trial which may influence the management
of their CML disease will be excluded at the time of entry into the interventional
trial
We found this trial at
144
sites
Portsmouth, New Hampshire 03801
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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6405 N Federal Hwy # 300
Fort Lauderdale, Florida 33308
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200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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Los Angeles, California 90033
213) 740-2311
University of Southern California The University of Southern California is one of the world’s leading...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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105 West 8th Avenue
Spokane, Washington 99220
(509) 474-3131
Providence Cancer Center at Sacred Heart Medical Center When Mother Joseph and the Sisters of...
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490 North Washington Avenue
Titusville, Florida 32796
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820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
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1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Akron General Medical Center It
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1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Lehigh Valley Hospital At Lehigh Valley Health Network, we continually go the extra mile to...
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Amarillo, Texas 79106
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Anaheim, California 92801
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Anderson, Indiana 46016
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Arlington, Texas 76014
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Atlanta, Georgia 30309
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Attleboro, Massachusetts 02703
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Austin, Texas 78759
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Beaumont, Texas 77701
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801 Ostrum St
Bethlehem, Pennsylvania 18015
(484) 526-4000
St Luke'S Hospital And Health Network St. Luke's University Health Network (SLUHN) is a nonprofit,...
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801 North 29th Street
Billings, Montana 59107
406-238-2500
Billings Clinic Based in Billings, Montana, Billings Clinic is a community-governed health care organization consisting...
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Blois cedex, 41016
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Boston, Massachusetts 02130
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Bronx, New York 10461
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Burlington, North Carolina 27215
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4875 Higbee Ave NW
Canton, Ohio 44718
330-492-3345
Gabrail Cancer Center Since 1990, Gabrail Cancer Center has built a national reputation for excellence...
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Cary, North Carolina 27511
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Charleston, South Carolina
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Charleston, West Virginia 25304
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Columbia, Maryland 21044
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Cranston, Rhode Island 02920
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Danville, Virginia 24541
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Escondido, California 92025
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Evergreen Park, Illinois 60805
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Fall River, Massachusetts 02720
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Frederick, Maryland 21701
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Fredericksburg, Virginia 22408
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Gastonia, North Carolina 28054
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Geneva, Illinois 60134
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Glendora, California 91741
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1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hialeah, Florida 33012
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Honolulu, Hawaii 96813
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Honolulu, Hawaii 96813
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Honolulu, Hawaii 96819
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Hot Springs National Park, Arkansas 71913
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Houston, Texas 77030
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Houston, Texas 77030
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Hutchinson, Kansas 67502
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Indianapolis, Indiana 46254
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Jacksonville, Florida
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Jacksonville, Florida 32209
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Johnson City, New York 13790
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Jonesboro, Arkansas 72401
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Knoxville, Tennessee 37920
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Lafayette, Indiana
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Lakeland, Florida 33805
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Lancaster, Pennsylvania 17601
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409 West Circle Drive
Lansing, Michigan 48910
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Leesburg, Florida 34748
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Lewisville, Texas 75067
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1740 Nicholasville Rd
Lexington, Kentucky 40503
(859) 260-6100
Central Baptist Hospital Located in Lexington, Ky., Baptist Health Lexington offers some of the most...
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Manchester, Connecticut 06040
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Marietta, Georgia 30060
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Mason City, Iowa 50401
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Mesquite, Texas 75150
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Morristown, New Jersey 07960
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Muscle Shoals, Alabama 35661
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New Albany, Indiana 47150
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New Orleans, Louisiana 70121
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New Port Richey, Florida 34655
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New York, New York 10013
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New York, New York 10019
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Newark, Ohio 43055
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Newport News, Virginia 23601
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Niles, Illinois 60076
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Normal, Illinois 61761
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North Chicago, Illinois 60064
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Omaha, Nebraska 68105
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Orange, California 92868
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Orlando, Florida 32806
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