Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting



Status:Active, not recruiting
Conditions:Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:1/25/2018
Start Date:December 2, 2010
End Date:August 30, 2020

Use our guide to learn which trials are right for you!

Studying Interventions for Managing Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY)

The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI)
in patients newly diagnosed with CML and their quality of life in a real-world setting.

Time Perspective : Most patients are expected to be a mix of retrospective and prospective
data collection. Patients can be enrolled after their study index date (retrospective
component) and have to be followed until 5 years from study index date are complete (time
between enrollment and 5 year follow-up is the prospective component)

For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com.

Inclusion Criteria:

- Newly-diagnosed chronic phase chronic myeloid leukemia (CP-CML) patients who started
their first-line Tyrosine Kinase Inhibitor (TKI) treatment on imatinib, dasatinib or
nilotinib in accordance with the timelines below

- 18 years or older at time of of CP-CML diagnosis

a) Imatinib Cohorts

- Patients who started their first-line Imatinib treatment between January 2, 2008 and
September 30, 2010.Patients fitting this criterion are defined as retrospective
Imatinib patients

− Patients who started their first-line Imatinib treatment on or after October 1, 2010

b) Dasatinib Cohort

- Patients who started their first-line Dasatinib treatment after the drug was approved
in this indication

c) Nilotinib Cohort

- Patients who started their first-line Nilotinib treatment after the drug was approved
in this indication

- Patients are also eligible when they have already switched to a subsequent therapy
(TKI or other) at the time of enrollment, as long as their first-line and subsequent
CML treatment information is available at site for data entry into the study
Electronic Case Report Form (eCRF)

- Receiving treatment at medical practice (eg. community-based, office-based,
hospital-based, academic setting, oncology center)

Exclusion Criteria:

- Patients who are participating in an interventional trial which may influence the
management of their CML disease will be excluded

Discontinuation Criteria:

- Enrolled patients who join an interventional trial which may influence the management
of their CML disease will be excluded at the time of entry into the interventional
trial
We found this trial at
144
sites
2811 Tieton Drive
Yakima, Washington 98902
875
mi
from 91732
Yakima, WA
Click here to add this to my saved trials
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
1919
mi
from 91732
Atlanta, GA
Click here to add this to my saved trials
6405 N Federal Hwy # 300
Fort Lauderdale, Florida 33308
2314
mi
from 91732
Fort Lauderdale, FL
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
1836
mi
from 91732
Kalamazoo, MI
Click here to add this to my saved trials
Los Angeles, California 90033
213) 740-2311
University of Southern California The University of Southern California is one of the world’s leading...
11
mi
from 91732
Los Angeles, CA
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
827
mi
from 91732
Portland, OR
Click here to add this to my saved trials
105 West 8th Avenue
Spokane, Washington 99220
(509) 474-3131
Providence Cancer Center at Sacred Heart Medical Center When Mother Joseph and the Sisters of...
938
mi
from 91732
Spokane, WA
Click here to add this to my saved trials
490 North Washington Avenue
Titusville, Florida 32796
2214
mi
from 91732
Titusville, FL
Click here to add this to my saved trials
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
930
mi
from 91732
Wenatchee, WA
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Akron General Medical Center It
2038
mi
from 91732
Akron, OH
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Lehigh Valley Hospital At Lehigh Valley Health Network, we continually go the extra mile to...
2356
mi
from 91732
Allentown, PA
Click here to add this to my saved trials
Amarillo, Texas 79106
918
mi
from 91732
Amarillo, TX
Click here to add this to my saved trials
Anaheim, California 92801
16
mi
from 91732
Anaheim, CA
Click here to add this to my saved trials
Anderson, Indiana 46016
1819
mi
from 91732
Anderson, IN
Click here to add this to my saved trials
Arlington, Texas 76014
1208
mi
from 91732
Arlington, TX
Click here to add this to my saved trials
Atlanta, Georgia 30309
1918
mi
from 91732
Atlanta, GA
Click here to add this to my saved trials
Attleboro, Massachusetts 02703
2568
mi
from 91732
Attleboro, MA
Click here to add this to my saved trials
Austin, Texas 78759
1212
mi
from 91732
Austin, TX
Click here to add this to my saved trials
Beaumont, Texas 77701
1423
mi
from 91732
Beaumont, TX
Click here to add this to my saved trials
959
mi
from 91732
Bellevue, WA
Click here to add this to my saved trials
801 Ostrum St
Bethlehem, Pennsylvania 18015
(484) 526-4000
St Luke'S Hospital And Health Network St. Luke's University Health Network (SLUHN) is a nonprofit,...
2361
mi
from 91732
Bethlehem, PA
Click here to add this to my saved trials
801 North 29th Street
Billings, Montana 59107
406-238-2500
Billings Clinic Based in Billings, Montana, Billings Clinic is a community-governed health care organization consisting...
949
mi
from 91732
Billings, MT
Click here to add this to my saved trials
Blois cedex, 41016
1877
mi
from 91732
Blois cedex,
Click here to add this to my saved trials
Boston, Massachusetts 02130
2578
mi
from 91732
Boston, MA
Click here to add this to my saved trials
815
mi
from 91732
Boulder, CO
Click here to add this to my saved trials
2309
mi
from 91732
Boynton Beach, FL
Click here to add this to my saved trials
Bronx, New York 10461
2441
mi
from 91732
Bronx, NY
Click here to add this to my saved trials
Burlington, North Carolina 27215
2171
mi
from 91732
Burlington, NC
Click here to add this to my saved trials
4875 Higbee Ave NW
Canton, Ohio 44718
330-492-3345
Gabrail Cancer Center Since 1990, Gabrail Cancer Center has built a national reputation for excellence...
2044
mi
from 91732
Canton, OH
Click here to add this to my saved trials
Cary, North Carolina 27511
2211
mi
from 91732
Cary, NC
Click here to add this to my saved trials
Charleston, South Carolina
2184
mi
from 91732
Charleston, SC
Click here to add this to my saved trials
Charleston, West Virginia 25304
2038
mi
from 91732
Charleston, WV
Click here to add this to my saved trials
Columbia, Maryland 21044
2288
mi
from 91732
Columbia, MD
Click here to add this to my saved trials
Cranston, Rhode Island 02920
2561
mi
from 91732
Cranston, RI
Click here to add this to my saved trials
1224
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1226
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1221
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
Danville, Virginia 24541
2167
mi
from 91732
Danville, VA
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
2203
mi
from 91732
Durham, NC
Click here to add this to my saved trials
Escondido, California 92025
86
mi
from 91732
Escondido, CA
Click here to add this to my saved trials
Evergreen Park, Illinois 60805
1724
mi
from 91732
Evergreen Park, IL
Click here to add this to my saved trials
Fall River, Massachusetts 02720
2576
mi
from 91732
Fall River, MA
Click here to add this to my saved trials
Frederick, Maryland 21701
2259
mi
from 91732
Frederick, MD
Click here to add this to my saved trials
Fredericksburg, Virginia 22408
2262
mi
from 91732
Fredericksburg, VA
Click here to add this to my saved trials
Gastonia, North Carolina 28054
2084
mi
from 91732
Gastonia, NC
Click here to add this to my saved trials
Geneva, Illinois 60134
1695
mi
from 91732
Geneva, IL
Click here to add this to my saved trials
Glendora, California 91741
9
mi
from 91732
Glendora, CA
Click here to add this to my saved trials
1843
mi
from 91732
Grand Rapids, MI
Click here to add this to my saved trials
1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
2290
mi
from 91732
Greenville, NC
Click here to add this to my saved trials
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
2430
mi
from 91732
Hackensack, NJ
Click here to add this to my saved trials
Hialeah, Florida 33012
2313
mi
from 91732
Hialeah, FL
Click here to add this to my saved trials
Honolulu, Hawaii 96813
2573
mi
from 91732
Honolulu, HI
Click here to add this to my saved trials
Honolulu, Hawaii 96813
2573
mi
from 91732
Honolulu, HI
Click here to add this to my saved trials
Honolulu, Hawaii 96819
2573
mi
from 91732
Honolulu, HI
Click here to add this to my saved trials
Hot Springs National Park, Arkansas 71913
1420
mi
from 91732
Hot Springs National Park, AR
Click here to add this to my saved trials
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
Hutchinson, Kansas 67502
1152
mi
from 91732
Hutchinson, KS
Click here to add this to my saved trials
1793
mi
from 91732
Indianapolis, IN
Click here to add this to my saved trials
Indianapolis, Indiana 46254
1787
mi
from 91732
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida
2130
mi
from 91732
Jacksonville, FL
Click here to add this to my saved trials
Jacksonville, Florida 32209
2139
mi
from 91732
Jacksonville, FL
Click here to add this to my saved trials
Johnson City, New York 13790
2328
mi
from 91732
Johnson City, NY
Click here to add this to my saved trials
Jonesboro, Arkansas 72401
1547
mi
from 91732
Jonesboro, AR
Click here to add this to my saved trials
2332
mi
from 91732
Kingston, PA
Click here to add this to my saved trials
Knoxville, Tennessee 37920
1925
mi
from 91732
Knoxville, TN
Click here to add this to my saved trials
Knoxville, Tennessee 37920
1925
mi
from 91732
Knoxville, TN
Click here to add this to my saved trials
Lafayette, Indiana
1757
mi
from 91732
Lafayette, IN
Click here to add this to my saved trials
Lakeland, Florida 33805
2163
mi
from 91732
Lakeland, FL
Click here to add this to my saved trials
Lancaster, Pennsylvania 17601
2313
mi
from 91732
Lancaster, PA
Click here to add this to my saved trials
409 West Circle Drive
Lansing, Michigan 48910
1897
mi
from 91732
Lansing, MI
Click here to add this to my saved trials
Leesburg, Florida 34748
2149
mi
from 91732
Leesburg, FL
Click here to add this to my saved trials
Lewisville, Texas 75067
1210
mi
from 91732
Lewisville, TX
Click here to add this to my saved trials
1740 Nicholasville Rd
Lexington, Kentucky 40503
(859) 260-6100
Central Baptist Hospital Located in Lexington, Ky., Baptist Health Lexington offers some of the most...
1879
mi
from 91732
Lexington, KY
Click here to add this to my saved trials
1463
mi
from 91732
Little Rock, AR
Click here to add this to my saved trials
1812
mi
from 91732
Louisville, KY
Click here to add this to my saved trials
Manchester, Connecticut 06040
2505
mi
from 91732
Manchester, CT
Click here to add this to my saved trials
Marietta, Georgia 30060
1908
mi
from 91732
Marietta, GA
Click here to add this to my saved trials
2229
mi
from 91732
Martinsburg, WV
Click here to add this to my saved trials
Mason City, Iowa 50401
1471
mi
from 91732
Mason City, IA
Click here to add this to my saved trials
1297
mi
from 91732
McAllen, TX
Click here to add this to my saved trials
Mesquite, Texas 75150
1233
mi
from 91732
Mesquite, TX
Click here to add this to my saved trials
Miami, Florida
2322
mi
from 91732
Miami, FL
Click here to add this to my saved trials
1886
mi
from 91732
Middletown, OH
Click here to add this to my saved trials
932
mi
from 91732
Midland, TX
Click here to add this to my saved trials
Morristown, New Jersey 07960
2407
mi
from 91732
Morristown, NJ
Click here to add this to my saved trials
Muscle Shoals, Alabama 35661
1725
mi
from 91732
Muscle Shoals, AL
Click here to add this to my saved trials
New Albany, Indiana 47150
1809
mi
from 91732
New Albany, IN
Click here to add this to my saved trials
New Orleans, Louisiana 70121
1650
mi
from 91732
New Orleans, LA
Click here to add this to my saved trials
New Port Richey, Florida 34655
2118
mi
from 91732
New Port Richey, FL
Click here to add this to my saved trials
New York, New York 10013
2432
mi
from 91732
New York, NY
Click here to add this to my saved trials
New York, New York 10019
2433
mi
from 91732
New York, NY
Click here to add this to my saved trials
Newark, Ohio 43055
1992
mi
from 91732
Newark, OH
Click here to add this to my saved trials
Newport News, Virginia 23601
2326
mi
from 91732
Newport News, VA
Click here to add this to my saved trials
Niles, Illinois 60076
1726
mi
from 91732
Niles, IL
Click here to add this to my saved trials
Normal, Illinois 61761
1647
mi
from 91732
Normal, IL
Click here to add this to my saved trials
North Chicago, Illinois 60064
1723
mi
from 91732
North Chicago, IL
Click here to add this to my saved trials
1579
mi
from 91732
Odessa, TX
Click here to add this to my saved trials
Omaha, Nebraska 68105
1299
mi
from 91732
Omaha, NE
Click here to add this to my saved trials
Orange, California 92868
21
mi
from 91732
Orange, CA
Click here to add this to my saved trials
Orlando, Florida 32806
2186
mi
from 91732
Orlando, FL
Click here to add this to my saved trials