A Study of Response-Guided Duration of Combination Therapy With GS-9451, Pegasys® and Copegus® With and Without Tegobuvir (GS-9190) in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C



Status:Archived
Conditions:Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2010
End Date:December 2015

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A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating 16 and 24 Weeks of Four-Drug Regimen and 24 Weeks of a Three-Drug Regimen of GS-9451, Peginterferon Alfa 2a (PEG, Pegasys®) and Ribavirin (RBV, Copegus®) With and Without Tegobuvir (GS-9190) Followed by Response Guided PEG and RBV in Treatment Naïve Subjects With Chronic Genotype 1 Hepatitis C Virus Infection (Protocol No. GS US 196 0140


This phase 2b study will evaluate the efficacy and safety of 16 and 24 weeks of a 4-drug
regimen with GS-9451 and Tegobuvir and 24 weeks of a 3-drug regimen of GS-9451 without
Tegobuvir, all with Peginterferon Alfa-2a (Pegasys®) and Ribavirin (Copegus®).



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Arlington, Texas 76012
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Arlington, TX
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860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
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DeLand, FL
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
2301
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Baltimore, MD
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175 Cross Keys Rd.
Berlin, New Jersey 08009
856-753-7335
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Berlin, NJ
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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201 East Huron Street
Chicago, Illinois 60611
(847) 491-3741
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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Chicago, IL
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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234 Goodman Dr
Cincinnati, Ohio 45229
(513) 584-1000
University of Cincinnati Medical Center Opening in 1823 as the country
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Cincinnati, OH
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5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
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Gainesville, Florida 32611
(352) 392-3261
University of Florida Gainesville UF has a long history of established programs in international education,...
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5615 Kirby Dr.
Houston, Texas 77005
713-442-1223
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425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Indianapolis, IN
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
13
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300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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Manhasset, NY
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1 Gustave L Levy Pl # 271
New York, New York 10029
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Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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110 Irving St NW # 3B28
Washington, Washington DC 20010
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Washington, DC
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Albuquerque, New Mexico 87106
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Asheville, North Carolina 28801
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Atlanta, Georgia 30342
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Atlanta, Georgia 30309
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Atlanta, Georgia 30322
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Beverly Hills, California 90211
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Binghamton, New York 13903
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Boulder, Colorado 80309
(303) 492-1411
University of Colorado, Boulder As the flagship university of the state of Colorado, CU-Boulder is...
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Bowling Green, Kentucky 42101
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Bradenton, Florida 34209
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Bristol, Tennessee 37620
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1300 Morris Park Ave
Bronx, New York 10461
(718) 430-2000
Albert Einstein College of Medicine The Albert Einstein College of Medicine of Yeshiva University is...
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Chula Vista, California 91911
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Chula Vista, CA
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1879
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Cincinnati, OH
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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Cleveland, OH
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Decatur, Georgia 30033
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Decatur, GA
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Decatur, GA
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2799 W Grand Blvd
Detroit, Michigan 48202
(888) 777-4167
Josephine Ford Cancer Center at Henry Ford Hospital A diagnosis of cancer is one of...
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Detroit, MI
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1895
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Dothan, AL
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Englewood, Colorado 80113
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Fairfax, Virginia 22031
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Ft Sam Houston, Texas 78234
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Germantown, Tennessee 38138
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Hialeah, Florida 33016
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Hillsborough, New Jersey 08844
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Houston, Texas 77030
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Houston, Texas 77030
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Houston, Texas 77090
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Houston, Texas 77030
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Indianapolis, Indiana 46237
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Jackson, Mississippi 39202
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LaJolla, California 92037
95
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530 S Jackson St
Louisville, Kentucky 40202
502-562-3226
University of Louisville Hospital As the academic hospital at the heart of the Louisville Metro...
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Madison, Wisconsin 53706
(608) 263-2400
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
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Montgomery, AL
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Morristown, New Jersey 07960
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Mountain Home, Tennessee 37684
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National City, California 91950
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New Brunswick, New Jersey 08901
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New York, New York 10016
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550 1st Ave
New York, New York 10016
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New York University Langone Medical Center NYU NYU Langone Medical Center, a world-class, patient-centered, integrated,...
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722 W 168th St
New York, New York 10032
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Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Norfolk, Virginia 23502
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North Miami, Florida 33161
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1701 North Mills Avenue
Orlando, Florida 32803
(407)647-3960
Orlando Immunology Center Orlando Immunology Center , or simply (OIC) is a part of Infectious...
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601 E Rollins St
Orlando, Florida 32803
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Florida Hospital Florida Hospital is one of the country
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Phoenix, Arizona 85054
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Plymouth, Minnesota 55446
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San Antonio, Texas 78215
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San Diego, California 92015
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San Diego, California 92123
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San Francisco, California 94121
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45 Castro Street
San Francisco, California 94114
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California Pacific Medical Center California Pacific Medical Center is one of the largest private, not-for-profit,...
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Seattle, Washington 98101
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Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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St Louis, Missouri 63104
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Tucson, Arizona 85721
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University of Arizona The University of Arizona is a premier, public research university. Established in...
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Tulsa, Oklahoma 74104
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Vallejo, California 94589
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Wellington, FL
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Worcester, Massachusetts 01608
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