Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia



Status:Active, not recruiting
Conditions:Blood Cancer, Leukemia
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:1/26/2019
Start Date:April 1999

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Molecular Genetic Features of Acute Leukemia

This research trial studies molecular genetic features in blood and tissue samples from
patients with newly diagnosed acute lymphoblastic leukemia or acute promyelocytic leukemia.
Studying samples of blood and tissue from patients with acute lymphoblastic leukemia or acute
promyelocytic leukemia in the laboratory may help doctors identify and learn more about
biomarkers related to cancer.

Objectives:

1. To perform quantitative PCR using known leukemia specific markers in diagnostic bone
marrow specimens of patients with newly diagnosed APL and ALL and to correlative
pre-treatment copy number with other biologic and molecular features, clinical response,
and treatment outcome.

2. To evaluate the expression of novel genes or microRNAs implicated in disease
pathogenesis and treatment response in pretreatment blood and bone marrow specimens of
patients with APL and ALL and to correlate expression level with other biological
features and treatment outcome.

3. To evaluate the clinical significance of sequential quantitative MRD measurements using
real-time quantitative PCR and/or flow cytometry during and following treatment of ALL
and APL and correlate these findings with efficacy of novel treatment approaches and
with other biological and clinical prognostic features.

4. To compare measurement of MRD in blood with bone marrow specimens in sequential
remission specimens of patients receiving treatment on ALL and APL treatment trials.

- Patients with a diagnosis of acute lymphoblastic leukemia (ALL) entered onto CALGB
treatment trials for previously untreated ALL must be enrolled on CALGB 9862. Entry on
CALGB 8461 is strongly encouraged.

- Patients with a diagnosis of acute promyelocytic leukemia (APL) enrolled on SWOG S0521
or S0535 must be enrolled on CALGB 9862.
We found this trial at
51
sites
750 E Adams St
Syracuse, New York 13210
(315) 464-5540
SUNY Upstate Medical University Hospital SUNY Upstate Medical University in Syracuse, NY, is the only...
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361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
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Augusta, ME
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417 State St #30
Bangor, Maine 04401
(207) 973-7478
CancerCare of Maine at Eastern Maine Medical Center Our compassionate, experienced physicians specialize in the...
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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115 Business loop 70 w
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
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600 Moye Boulevard
Greenville, North Carolina 27834
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900 West Faris Road
Greenville, South Carolina 29605
(864) 679-3900
Cancer Centers of the Carolinas - Faris Road Cancer Centers of the Carolinas is now...
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3 Butternut Drive, Suite B
Greenville, South Carolina 29605
(864) 241-7272
Cancer Centers of the Carolinas - Grove Commons Cancer Centers of the Carolinas is now...
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701 Grove Rd # 1
Greenville, South Carolina 29605
(864) 455-7000
Greenville Hospital Cancer Center Greenville Health System (GHS) is a public not-for-profit academic healthcare delivery...
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33 Villa Road, Suite 400
Greenville, South Carolina 29615
(864) 404-2045
CCOP - Greenville Cancer care in the last decade has made many advances. Most of...
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340 Medical Pkwy
Greer, South Carolina 29650
(864) 334-4900
Cancer Centers of the Carolinas - Greer Medical Oncology Cancer Centers of the Carolinas is...
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200 Hawkins Drive
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
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701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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902 Savannah Road
Lewes, Delaware 19958
(302) 645-3770
Tunnell Cancer Center at Beebe Medical Center The Robert & Eolyne Tunnell Cancer Center at...
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300 Community Drive
Manhasset, New York 11030
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425 E River Pkwy # 754
Minneapolis, Minnesota 55455
612-624-2620
Masonic Cancer Center at University of Minnesota The Masonic Cancer Center was founded in 1991....
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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1300 York Avenue # A421
New York, New York 10065
New York Weill Cornell Cancer Center at Cornell University Welcome to the Division of Hematology...
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2501 N Orange Ave # 235
Orlando, Florida 32804
(407) 303-1700
Florida Hospital Cancer Institute at Florida Hospital Orlando FHCI is the largest cancer center in...
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4800 Friendship Avenue
Pittsburgh, Pennsylvania 15224
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Comprehensive Cancer Center The Comprehensive Cancer Center at Rhode Island Hospital is...
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401 College Street
Richmond, Virginia 23298
(804) 828-0450
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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34800 Bob Wilson Dr,
San Diego, California 92134
(619) 532-6400
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
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1600 Divisadero Street
San Francisco, California 94115
888.689.8273
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
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100 Campus Dr # 108
Scarborough, Maine 04074
(207) 396-7600
Maine Center for Cancer Medicine and Blood Disorders - Scarborough Maine Center for Cancer Medicine...
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131 Lila Doyle Drive
Seneca, South Carolina 29672
(864) 888-3717
Cancer Centers of the Carolinas - Seneca Cancer Centers of the Carolinas is now Cancer...
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120 Dillon Dr
Spartanburg, South Carolina 29307
(864) 699-5700
Cancer Centers of the Carolinas - Spartanburg Cancer Centers of the Carolinas is now Cancer...
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42 E Laurel Rd # 2545
Voorhees, New Jersey 08043
(800) 826-6737
Cancer Institute of New Jersey at Cooper - Voorhees Cooper University Health Care, the clinical...
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1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Comprehensive Cancer Center Our newly expanded Comprehensive Cancer Center is the region’s...
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44 Binney St
Boston, Massachusetts 02115
(617) 632-6364
Dana-Farber/Brigham and Women's Cancer Center Boston's Brigham and Women's Hospital (BWH) is an international leader...
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101 Manning Drive
Chapel Hill, North Carolina 27514
(919) 966-0000
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill One of the...
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1801 West Taylor, Suite 1E
Chicago, Illinois 60612
312.355.1625
University of Illinois Cancer Center The University of Illinois Cancer Center is dedicated to reducing...
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20 Duke Clinic Cir
Durham, North Carolina 27710
(888) 275-3853
Duke Cancer Institute Leading-edge cancer care and research have been a hallmark of Duke Medicine...
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5008 Brittonfield Parkway
East Syracuse, New York 13057
(315) 472-7504
CCOP - Hematology-Oncology Associates of Central New York Hematology/Oncology Associates of CNY (HOACNY) has participated...
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Elkton, Maryland 21921
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Goldsboro, North Carolina 27534
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Jamaica, New York 11432
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270-05 76th Ave
New Hyde Park, New York 11040
(718) 470-7480
Long Island Jewish Medical Center Serving North Shore LIJ Health System employees and their families....
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4701 Ogletown-Stanton Road
Newark, Delaware 19713
302-623-4450
CCOP - Christiana Care Health Services Christiana Care's Cancer Research Program is part of a...
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164 Summit Ave
Providence, Rhode Island 02906
(401) 793-2500
Miriam Hospital The Miriam Hospital is a private, not-for-profit hospital, with a history of providing...
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