Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/30/2019
Start Date:July 9, 2009
End Date:November 2020

Use our guide to learn which trials are right for you!

A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer

The purpose of this study is to investigate whether neratinib can further reduce the risk of
recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment
with trastuzumab.


Inclusion Criteria:

- Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.

- Been treated for early breast cancer with standard of care duration of trastuzumab.

- Could have been treated neoadjuvantly but have not reached pathologic complete
response.

Exclusion Criteria:

- Positive clinical and radiologic assessments for local or regional recurrence of
disease at the time of study entry.

- History of heart disease.

- Corrected QT (QTc) interval >0.45 seconds

- History of gastrointestinal disease with diarrhea as the major symptom.
We found this trial at
186
sites
Gettysburg, Pennsylvania 17325
2266
mi
from 91732
Gettysburg, PA
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
2578
mi
from 91732
Boston, MA
Click here to add this to my saved trials
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
1966
mi
from 91732
Detroit, MI
Click here to add this to my saved trials
3525
Lakeland, Florida 33805
2161
mi
from 91732
Lakeland, FL
Click here to add this to my saved trials
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
1762
mi
from 91732
Nashville, TN
Click here to add this to my saved trials
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
2184
mi
from 91732
Orlando, FL
Click here to add this to my saved trials
1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
2276
mi
from 91732
Port Saint Lucie, FL
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
827
mi
from 91732
Portland, OR
Click here to add this to my saved trials
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
930
mi
from 91732
Wenatchee, WA
Click here to add this to my saved trials
427 West 3rd Avenue
Albany, Georgia 31701
1964
mi
from 91732
Albany, GA
Click here to add this to my saved trials
901 Leighton Avenue
Anniston, Alabama 36207
1839
mi
from 91732
Anniston, AL
Click here to add this to my saved trials
Ashland, Kentucky 41101
1981
mi
from 91732
Ashland, KY
Click here to add this to my saved trials
Atlanta, Georgia 30318
1915
mi
from 91732
Atlanta, GA
Click here to add this to my saved trials
820 Saint Sebastian Way
Augusta, Georgia 30901
2058
mi
from 91732
Augusta, GA
Click here to add this to my saved trials
Austin, Texas 78731
1208
mi
from 91732
Austin, TX
Click here to add this to my saved trials
2319
mi
from 91732
Aventura, FL
Click here to add this to my saved trials
227 Saint Paul Place
Baltimore, Maryland 21202
2301
mi
from 91732
Baltimore, MD
Click here to add this to my saved trials
9103 Franklin Square Drive
Baltimore, Maryland 21237
2308
mi
from 91732
Baltimore, MD
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
1589
mi
from 91732
Baton Rouge, LA
Click here to add this to my saved trials
Bedford, Texas 76022
1203
mi
from 91732
Bedford, TX
Click here to add this to my saved trials
Bend, Oregon 97701
714
mi
from 91732
Bend, OR
Click here to add this to my saved trials
2468
mi
from 91732
Bennington, VT
Click here to add this to my saved trials
Bethlehem, Pennsylvania 18015
2363
mi
from 91732
Bethlehem, PA
Click here to add this to my saved trials
Beverly Hills, California 90021
20
mi
from 91732
Beverly Hills, CA
Click here to add this to my saved trials
1785
mi
from 91732
Birmingham, AL
Click here to add this to my saved trials
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
1259
mi
from 91732
Bismarck, ND
Click here to add this to my saved trials
Boynton Beach, Florida 33426
2308
mi
from 91732
Boynton Beach, FL
Click here to add this to my saved trials
Bronx, New York 10469
2440
mi
from 91732
Bronx, NY
Click here to add this to my saved trials
Charleston, South Carolina 29403
2183
mi
from 91732
Charleston, SC
Click here to add this to my saved trials
2184
mi
from 91732
Charleston, SC
Click here to add this to my saved trials
979 East 3rd Street
Chattanooga, Tennessee 37403
1854
mi
from 91732
Chattanooga, TN
Click here to add this to my saved trials
Cherry Hill, New Jersey 08003
2382
mi
from 91732
Cherry Hill, NJ
Click here to add this to my saved trials
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
1726
mi
from 91732
Chicago, IL
Click here to add this to my saved trials
Cincinnati, Ohio 45219
1879
mi
from 91732
Cincinnati, OH
Click here to add this to my saved trials
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
1880
mi
from 91732
Cincinnati, OH
Click here to add this to my saved trials
2032
mi
from 91732
Cleveland, OH
Click here to add this to my saved trials
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
2032
mi
from 91732
Cleveland, OH
Click here to add this to my saved trials
115 North Sumter Street
Columbia, South Carolina 29203
2145
mi
from 91732
Columbia, SC
Click here to add this to my saved trials
100 Medical Park Drive Northeast
Concord, North Carolina 28025
2112
mi
from 91732
Concord, NC
Click here to add this to my saved trials
Cookeville, Tennessee 38501
1833
mi
from 91732
Cookeville, TN
Click here to add this to my saved trials
Corpus Christi, Texas 78463
1290
mi
from 91732
Corpus Christi, TX
Click here to add this to my saved trials
Corpus Christi, Texas 78374
1295
mi
from 91732
Corpus Christi, TX
Click here to add this to my saved trials
Corpus Christi, Texas 78412
1298
mi
from 91732
Corpus Christi, TX
Click here to add this to my saved trials
776
mi
from 91732
Corvallis, OR
Click here to add this to my saved trials
Dallas, Texas 75230
1223
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
Dallas, Texas 75246
1225
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1225
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1221
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1645
mi
from 91732
Decatur, IL
Click here to add this to my saved trials
Deerfield Beach, Florida 33064
2313
mi
from 91732
Deerfield Beach, FL
Click here to add this to my saved trials
Denton, Texas 76210
1204
mi
from 91732
Denton, TX
Click here to add this to my saved trials
20 Duke Medicine Circle
Durham, North Carolina 27710
2199
mi
from 91732
Durham, NC
Click here to add this to my saved trials
686
mi
from 91732
El Paso, TX
Click here to add this to my saved trials
685
mi
from 91732
El Paso, TX
Click here to add this to my saved trials
Elizabeth, New Jersey 07207
2422
mi
from 91732
Elizabeth, NJ
Click here to add this to my saved trials
2269
mi
from 91732
Fairfax, VA
Click here to add this to my saved trials
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
2269
mi
from 91732
Fairfax, VA
Click here to add this to my saved trials
401 East Cheves Street
Florence, South Carolina 29506
2174
mi
from 91732
Florence, SC
Click here to add this to my saved trials
Fort Gordon, Georgia 30905
2050
mi
from 91732
Fort Gordon, GA
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
2317
mi
from 91732
Fort Lauderdale, FL
Click here to add this to my saved trials
Fort Worth, Texas 76104
?
mi
from 91732
Fort Worth, TX
Click here to add this to my saved trials
2102
mi
from 91732
Gainesville, FL
Click here to add this to my saved trials
Garland, Texas 75042
1229
mi
from 91732
Garland, TX
Click here to add this to my saved trials
Germantown, Tennessee 38138
1600
mi
from 91732
Germantown, TN
Click here to add this to my saved trials
Gilroy, California 95020
284
mi
from 91732
Gilroy, CA
Click here to add this to my saved trials
1509 Wilson Terrace
Glendale, California 91206
13
mi
from 91732
Glendale, CA
Click here to add this to my saved trials
1843
mi
from 91732
Grand Rapids, MI
Click here to add this to my saved trials
233 Fulton Street East
Grand Rapids, Michigan 49503
1840
mi
from 91732
Grand Rapids, MI
Click here to add this to my saved trials
2845 Greenbrier Rd
Green Bay, Wisconsin 54311
(920) 288-8000
Aurora BayCare Medical Center Aurora BayCare Medical Center is a 167-bed, full-service hospital serving the...
1749
mi
from 91732
Green Bay, WI
Click here to add this to my saved trials
Greenbrae, California 94904
368
mi
from 91732
Greenbrae, CA
Click here to add this to my saved trials
4300 Londonderry Road
Harrisburg, Pennsylvania 17109
2286
mi
from 91732
Harrisburg, PA
Click here to add this to my saved trials
Highland, California 92346
46
mi
from 91732
Highland, CA
Click here to add this to my saved trials
Hilton Head Island, South Carolina 29926
2147
mi
from 91732
Hilton Head Island, SC
Click here to add this to my saved trials
888 S King St
Honolulu, Hawaii 96813
(808) 522-4000
Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
2572
mi
from 91732
Honolulu, HI
Click here to add this to my saved trials
Houston, Texas 77024
1349
mi
from 91732
Houston, TX
Click here to add this to my saved trials
6550 Fannin Street
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
14090 Southwest Freeway
Houston, Texas 77055
1347
mi
from 91732
Houston, TX
Click here to add this to my saved trials
1358
mi
from 91732
Houston, TX
Click here to add this to my saved trials
Indianapolis, Indiana 46227
1794
mi
from 91732
Indianapolis, IN
Click here to add this to my saved trials
Indianapolis, Indiana 46260
1792
mi
from 91732
Indianapolis, IN
Click here to add this to my saved trials
Jefferson City, Missouri 65109
1462
mi
from 91732
Jefferson City, MO
Click here to add this to my saved trials
1704
mi
from 91732
Joliet, IL
Click here to add this to my saved trials
Jonesboro, Arkansas 72401
1547
mi
from 91732
Jonesboro, AR
Click here to add this to my saved trials
Kirkland, Washington 98034
967
mi
from 91732
Kirkland, WA
Click here to add this to my saved trials
1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
1923
mi
from 91732
Knoxville, TN
Click here to add this to my saved trials
Lake Success, New York 11042
2448
mi
from 91732
Lake Success, NY
Click here to add this to my saved trials
300 Main Street
Lewiston, Maine 04240
2616
mi
from 91732
Lewiston, ME
Click here to add this to my saved trials
1256
mi
from 91732
Lincoln, NE
Click here to add this to my saved trials
94 Old Short Hills Road
Livingston, New Jersey 07039
2417
mi
from 91732
Livingston, NJ
Click here to add this to my saved trials
Long Beach, California 90806
21
mi
from 91732
Long Beach, CA
Click here to add this to my saved trials
Long Beach, California 90801
21
mi
from 91732
Long Beach, CA
Click here to add this to my saved trials
12993 Southern Boulevard
Loxahatchee Groves, Florida 33470
2294
mi
from 91732
Loxahatchee Groves, FL
Click here to add this to my saved trials
Marrero, Louisiana 70072
1655
mi
from 91732
Marrero, LA
Click here to add this to my saved trials
Middletown, Ohio 45042
1885
mi
from 91732
Middletown, OH
Click here to add this to my saved trials
Minneapolis, Minnesota 55405
1508
mi
from 91732
Minneapolis, MN
Click here to add this to my saved trials
Mission Hills, California
29
mi
from 91732
Mission Hills, CA
Click here to add this to my saved trials
Missoula, Montana 59802
909
mi
from 91732
Missoula, MT
Click here to add this to my saved trials
Moline, Illinois 61265
1579
mi
from 91732
Moline, IL
Click here to add this to my saved trials
Monongahela, Pennsylvania 15063
2124
mi
from 91732
Monongahela, PA
Click here to add this to my saved trials
2122
mi
from 91732
Morgantown, WV
Click here to add this to my saved trials
Morristown, New Jersey 07960
2407
mi
from 91732
Morristown, NJ
Click here to add this to my saved trials