Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/30/2019
Start Date:July 9, 2009
End Date:November 2020

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer

The purpose of this study is to investigate whether neratinib can further reduce the risk of
recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment
with trastuzumab.


Inclusion Criteria:

- Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.

- Been treated for early breast cancer with standard of care duration of trastuzumab.

- Could have been treated neoadjuvantly but have not reached pathologic complete
response.

Exclusion Criteria:

- Positive clinical and radiologic assessments for local or regional recurrence of
disease at the time of study entry.

- History of heart disease.

- Corrected QT (QTc) interval >0.45 seconds

- History of gastrointestinal disease with diarrhea as the major symptom.
We found this trial at
186
sites
El Paso Cancer Treatment Ctr - West
El Paso, Texas 79902
1425
mi
from 43215
El Paso, TX
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
643
mi
from 43215
Boston, MA
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Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
164
mi
from 43215
Detroit, MI
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Lakeland Regional Cancer Center
3525
Lakeland, Florida 33805
822
mi
from 43215
Lakeland, FL
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
334
mi
from 43215
Nashville, TN
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M.D. Anderson Cancer Center at Orlando
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
795
mi
from 43215
Orlando, FL
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Hematology Oncology Associates of Treasure Coast
1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
889
mi
from 43215
Port Saint Lucie, FL
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
2026
mi
from 43215
Portland, OR
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Wenatchee Valley Medical Center
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
1912
mi
from 43215
Wenatchee, WA
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Phoebe Cancer Center
427 West 3rd Avenue
Albany, Georgia 31701
582
mi
from 43215
Albany, GA
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Anniston Oncology
901 Leighton Avenue
Anniston, Alabama 36207
462
mi
from 43215
Anniston, AL
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Ashland Bellefonte Cancer Center
Ashland, Kentucky 41101
105
mi
from 43215
Ashland, KY
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Piedmont Cancer Institute, P.C.
Atlanta, Georgia 30318
433
mi
from 43215
Atlanta, GA
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Augusta Oncology Associates (ACORN), P.C.
820 Saint Sebastian Way
Augusta, Georgia 30901
452
mi
from 43215
Augusta, GA
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Texas Oncology
Austin, Texas 78731
1062
mi
from 43215
Austin, TX
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Innovative Medical Research of South Florida Inc.
Aventura, Florida 33180
981
mi
from 43215
Aventura, FL
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Medical Oncology & Hematology Mercy Medical Center
227 Saint Paul Place
Baltimore, Maryland 21202
344
mi
from 43215
Baltimore, MD
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Harry and Jeanette Weinberg Cancer Center
9103 Franklin Square Drive
Baltimore, Maryland 21237
350
mi
from 43215
Baltimore, MD
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Hematology-Oncology Clinic
Baton Rouge, Louisiana 70809
801
mi
from 43215
Baton Rouge, LA
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Texas Oncology, P.A.
Bedford, Texas 76022
925
mi
from 43215
Bedford, TX
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Bend Memorial Clinic
Bend, Oregon 97701
1966
mi
from 43215
Bend, OR
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Southwestern Vermont Regional Cancer Center
Bennington, Vermont 05201
547
mi
from 43215
Bennington, VT
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Oncology Hematology of Lehigh Valley
Bethlehem, Pennsylvania 18015
407
mi
from 43215
Bethlehem, PA
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Cedars-Sinai Medical Group
Beverly Hills, California 90021
1978
mi
from 43215
Beverly Hills, CA
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Birmingham Hematology and Oncology Associates, LLC
Birmingham, Alabama 35205
493
mi
from 43215
Birmingham, AL
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Mid Dakota Clinic, PC
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
1006
mi
from 43215
Bismarck, ND
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University Cancer Institute, LLC
Boynton Beach, Florida 33426
943
mi
from 43215
Boynton Beach, FL
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Eastchester Center for Cancer Care
Bronx, New York 10469
486
mi
from 43215
Bronx, NY
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Charleston Hematology/Oncology Associates, Pa
Charleston, South Carolina 29403
523
mi
from 43215
Charleston, SC
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Medical University of South Carolina Hollings Cancer Center
Charleston, South Carolina 29425
524
mi
from 43215
Charleston, SC
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University Hematology/Oncology Associates PLLC
979 East 3rd Street
Chattanooga, Tennessee 37403
361
mi
from 43215
Chattanooga, TN
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The Center for Cancer and Hematologic Disease
Cherry Hill, New Jersey 08003
423
mi
from 43215
Cherry Hill, NJ
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Rush University Medical Center
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
277
mi
from 43215
Chicago, IL
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Christ Hospital Cancer Center
Cincinnati, Ohio 45219
98
mi
from 43215
Cincinnati, OH
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University of Cincinnati
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
98
mi
from 43215
Cincinnati, OH
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University Hospitals of Cleveland Medical Center
Cleveland, Ohio 44012
127
mi
from 43215
Cleveland, OH
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MetroHealth Med Ctr
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
127
mi
from 43215
Cleveland, OH
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Francisco Gonzalez MD PA
115 North Sumter Street
Columbia, South Carolina 29203
442
mi
from 43215
Columbia, SC
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NorthEast Oncology Associates Carolinas Medical Center NorthEast
100 Medical Park Drive Northeast
Concord, North Carolina 28025
339
mi
from 43215
Concord, NC
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Cookeville Regional Cancer Center
Cookeville, Tennessee 38501
294
mi
from 43215
Cookeville, TN
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Coastal Bend Cancer Center
Corpus Christi, Texas 78463
1178
mi
from 43215
Corpus Christi, TX
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South Texas Institute of Cancer
Corpus Christi, Texas 78374
1166
mi
from 43215
Corpus Christi, TX
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Cancer Specialists Of South Texas, Pa
Corpus Christi, Texas 78412
1177
mi
from 43215
Corpus Christi, TX
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Samaritan Hematology & Oncology Consultants
Corvallis, Oregon 97330
2060
mi
from 43215
Corvallis, OR
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Center for Oncology Research
Dallas, Texas 75230
905
mi
from 43215
Dallas, TX
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Texas Oncology, PA
Dallas, Texas 75246
909
mi
from 43215
Dallas, TX
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Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
909
mi
from 43215
Dallas, TX
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University of Texas Southwestern Medical Center Simmons Cancer Center
2201 Inwood Road
Dallas, Texas 75390
911
mi
from 43215
Dallas, TX
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Cancer Care Specialists of Illinois, Decatur Memorial Hospital Clinical Research
210 West McKinley Avenue
Decatur, Illinois 62526
314
mi
from 43215
Decatur, IL
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North Broward Medical Center
Deerfield Beach, Florida 33064
960
mi
from 43215
Deerfield Beach, FL
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Texas Oncology, P.A.
Denton, Texas 76210
910
mi
from 43215
Denton, TX
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Duke University Medical Center Medical Oncology
20 Duke Medicine Circle
Durham, North Carolina 27710
352
mi
from 43215
Durham, NC
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The Center for Integrative Cancer Medicine
El Paso, Texas 79902
1424
mi
from 43215
El Paso, TX
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Trinitas Comprehensive Cancer Center
Elizabeth, New Jersey 07207
466
mi
from 43215
Elizabeth, NJ
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Medical Oncology and Hematology Associates of Northern Virginia
Fairfax, Virginia 22031
316
mi
from 43215
Fairfax, VA
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
316
mi
from 43215
Fairfax, VA
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McLeod Oncology and Hematology Associates
401 East Cheves Street
Florence, South Carolina 29506
437
mi
from 43215
Florence, SC
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Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia 30905
455
mi
from 43215
Fort Gordon, GA
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Broward General Medical Center
Fort Lauderdale, Florida 33316
972
mi
from 43215
Fort Lauderdale, FL
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Texas Oncology P.A.
Fort Worth, Texas 76104
?
mi
from 43215
Fort Worth, TX
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Florida Cancer Specialists & Research Institute
Gainesville, Florida 32605
711
mi
from 43215
Gainesville, FL
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Texas Oncology PA
Garland, Texas 75042
899
mi
from 43215
Garland, TX
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The Jones Clinic, PC
Germantown, Tennessee 38138
501
mi
from 43215
Germantown, TN
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Gettysburg Cancer Center
Gettysburg, Pennsylvania 17325
307
mi
from 43215
Gettysburg, PA
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Ronald Yanagihara MD - PP
Gilroy, California 95020
2077
mi
from 43215
Gilroy, CA
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Glendale Adventist Medical Center Cancer Services
1509 Wilson Terrace
Glendale, California 91206
1968
mi
from 43215
Glendale, CA
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Cancer and Hematology Centers of Western Michigan
Grand Rapids, Michigan 49503
247
mi
from 43215
Grand Rapids, MI
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Medical Specialty Associates
233 Fulton Street East
Grand Rapids, Michigan 49503
248
mi
from 43215
Grand Rapids, MI
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Aurora BayCare Medical Center
2845 Greenbrier Rd
Green Bay, Wisconsin 54311
(920) 288-8000
Aurora BayCare Medical Center Aurora BayCare Medical Center is a 167-bed, full-service hospital serving the...
400
mi
from 43215
Green Bay, WI
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California Cancer Care
Greenbrae, California 94904
2110
mi
from 43215
Greenbrae, CA
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Pinnacle Health Cancer Center Community Campus
4300 Londonderry Road
Harrisburg, Pennsylvania 17109
328
mi
from 43215
Harrisburg, PA
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Beaver Medical Group, L.P.
Highland, California 92346
1915
mi
from 43215
Highland, CA
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South Carolina Cancer Specialists
Hilton Head Island, South Carolina 29926
549
mi
from 43215
Hilton Head Island, SC
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Straub Clinic And Hospital
888 S King St
Honolulu, Hawaii 96813
(808) 522-4000
Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
4501
mi
from 43215
Honolulu, HI
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Texas Oncology - Memorial City
Houston, Texas 77024
996
mi
from 43215
Houston, TX
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The Methodist Hospital Breast Center
6550 Fannin Street
Houston, Texas 77030
995
mi
from 43215
Houston, TX
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Medicus Alliance Clinical Research Org., Inc.
14090 Southwest Freeway
Houston, Texas 77055
1008
mi
from 43215
Houston, TX
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Jabboury Foundation for Cancer Research, Inc.
Houston, Texas 77082
991
mi
from 43215
Houston, TX
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Central Indiana Cancer Centers
Indianapolis, Indiana 46227
165
mi
from 43215
Indianapolis, IN
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Hematology Oncology of Indiana
Indianapolis, Indiana 46260
167
mi
from 43215
Indianapolis, IN
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Capitol Comprehensive Cancer Care Clinic
Jefferson City, Missouri 65109
502
mi
from 43215
Jefferson City, MO
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Midwest Center for Hematology/Oncology
Joliet, Illinois 60432
284
mi
from 43215
Joliet, IL
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Northeast Arkansas Clinic
Jonesboro, Arkansas 72401
505
mi
from 43215
Jonesboro, AR
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Cascade Cancer Center
Kirkland, Washington 98034
2000
mi
from 43215
Kirkland, WA
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Thompson Cancer Survival Center
1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
281
mi
from 43215
Knoxville, TN
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ProHEALTH Care Associates
Lake Success, New York 11042
493
mi
from 43215
Lake Success, NY
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Central Maine Healthcare Corp
300 Main Street
Lewiston, Maine 04240
715
mi
from 43215
Lewiston, ME
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Southeast Nebraska Hematology & Oncology Consultants
Lincoln, Nebraska 68510
719
mi
from 43215
Lincoln, NE
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Saint Barnabas Health Care System
94 Old Short Hills Road
Livingston, New Jersey 07039
462
mi
from 43215
Livingston, NJ
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Breastlink Med Group Inc
Long Beach, California 90806
1975
mi
from 43215
Long Beach, CA
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Long Beach Memorial Medical Center
Long Beach, California 90801
1976
mi
from 43215
Long Beach, CA
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Hematology Oncology Associates
12993 Southern Boulevard
Loxahatchee Groves, Florida 33470
931
mi
from 43215
Loxahatchee Groves, FL
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Crescent City Research Consortium, LLC
Marrero, Louisiana 70072
802
mi
from 43215
Marrero, LA
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Signal Point Hematology/Oncology
Middletown, Ohio 45042
79
mi
from 43215
Middletown, OH
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Minnesota Oncology and Hematology, PA
Minneapolis, Minnesota 55405
627
mi
from 43215
Minneapolis, MN
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Facey Medical Group
Mission Hills, California
1978
mi
from 43215
Mission Hills, CA
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Montana Cancer Specialists
Missoula, Montana 59802
1614
mi
from 43215
Missoula, MT
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Medical Arts Associates, Ltd
Moline, Illinois 61265
404
mi
from 43215
Moline, IL
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Sweeney-Melenyser Pavillion
Monongahela, Pennsylvania 15063
165
mi
from 43215
Monongahela, PA
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West Virginia University/Mary Babb Randolph Cancer Center
Morgantown, West Virginia 26506
163
mi
from 43215
Morgantown, WV
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Summit Medical Group
Morristown, New Jersey 07960
453
mi
from 43215
Morristown, NJ
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