Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:2/21/2019
Start Date:January 28, 2019
End Date:July 1, 2021

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A Phase II Study of Rucaparib in Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-Small Cell Lung Cancer (LUNG-MAP Sub-Study)

This phase II Lung-MAP trial studies how well rucaparib works in treating patients with
genomic loss of heterozygosity (LOH) high and/or deleterious BRCA1/2 mutation stage IV
non-small cell lung cancer or that has come back. Rucaparib may stop the growth of tumor
cells by blocking some of the enzymes needed for cell growth.

PRIMARY OBJECTIVES:

I. To evaluate the overall response rate (ORR) (confirmed and unconfirmed, complete and
partial) associated with rucaparib in patients with genomic LOH high and/or deleterious
BRCA1/2 mutations within: Cohort 1: Patients with squamous cell histology or mixed histology
with a squamous component; Cohort 2: Patients with non-squamous histology (adenocarcinoma,
large cell, or non-small cell lung cancer [NSCLC] not otherwise specified [NOS]).

SECONDARY OBJECTIVES:

I. To evaluate investigator assessed progression-free survival (IA-PFS) and overall survival
(OS) associated with rucaparib within each cohort.

II. To evaluate duration of response among responders within each cohort. III. To evaluate
the frequency and severity of toxicities associated with rucaparib among all patients
enrolled on the study (combining cohorts).

TRANSLATIOAL MEDICINE OBJECTIVES:

I. To evaluate the association between alterations in deoxyribonucleic acid (DNA) repair
genes and response by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

II. To perform comprehensive next-generation sequencing of circulating tumor DNA (ctDNA) at
baseline in all patients to assess its clinical utility in comparison to tumor tissue
biomarker profiles.

III. To establish a tissue/blood repository from patients with refractory non-small cell lung
cancer (NSCLC).

OUTLINE:

Patients receive rucaparib orally (PO) twice daily (BID) on days 1-21. Courses repeat every
21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year, and
then every 6 months for up to 3 years.

Inclusion Criteria:

- Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON
ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master
Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)

- Patients must be assigned to S1900A. S1900A biomarker eligibility defined as LOH high
and/or deleterious BRCA1/2 mutation is as follows using the Foundation Medicine Inc
(FMI) tissue- assay:

- LOH; alteration type: loss of heterozygosity (LOH); eligible alteration: Genomic
LOH >= 21%

- BRCA; alteration type: homologous recombination deficiency (HRD); eligible
alteration: Deleterious mutations in BRCA1 or BRCA2

- Patients must not have had prior treatment with any PARP inhibitor, including
rucaparib, talazoparib, veliparib, olaparib, or niraparib. For information and a list
of PARP inhibitors, please consult the S1900A ? Poly Polymerase Inhibitors, Scott et
al., 2015 JCO ref from the link on the S1900A protocol abstract page of the SWOG
(http://swog.org) or CTSU (https://www.ctsu.org) websites.

- Patients must be able to take oral medications.

- Patients must not have a >= Grade 3 hypercholesterolaemia (defined by National Cancer
Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version [v]5)
within 28 days prior to sub-study registration.

- Patients must not have EGFR sensitizing mutations, EGFR T790M mutation, ALK gene
fusion, ROS 1 gene rearrangement, and BRAF V600E mutation unless they have progressed
following all standard of care targeted therapy.

- Patients must not have documented evidence of acute hepatitis or have an active or
uncontrolled infection.

- Patients with a known history of human immunodeficiency virus (HIV) seropositivity:

- Must have undetectable viral load using standard HIV assays in clinical practice.

- Must have CD4 count >= 400/mcL.

- Must not require prophylaxis for any opportunistic infections (i.e., fungal,
mycobacterium avium complex [mAC], or pneumocystis pneumonia [PCP] prophylaxis).

- Must not be newly diagnosed within 12 months prior to sub-study registration.

- Patients must have progressed (in the opinion of the treating physician) following the
most recent line of therapy.

- Patients must not have received any prior systemic therapy (systemic chemotherapy,
immunotherapy or investigational drug) within 21 days prior to sub-study registration.
Patients must have recovered (=< Grade 1) from any side effects of prior therapy.
Patients must not have received any radiation therapy within 14 days prior to
sub-study registration.

- Patients must not be planning to receive any concurrent chemotherapy, immunotherapy,
biologic or hormonal therapy for cancer treatment while receiving treatment on this
study. Concurrent use of hormones for non-cancer-related conditions (e.g., insulin for
diabetes and hormone replacement therapy) is acceptable.

- Patients must have measurable disease documented by computed tomography (CT) or
magnetic resonance imaging (MRI). The CT from a combined positron emission tomography
(PET)/CT may be used to document only non-measurable disease unless it is of
diagnostic quality. Measurable disease must be assessed within 28 days prior to
sub-study registration. Pleural effusions, ascites and laboratory parameters are not
acceptable as the only evidence of disease. Non-measurable disease must be assessed
within 42 days prior to sub-study registration. All disease must be assessed and
documented on the Baseline Tumor Assessment Form. Patients whose only measurable
disease is within a previous radiation therapy port must demonstrate clearly
progressive disease (in the opinion of the treating investigator) prior to
registration. CT and MRI scans must be submitted for central review via TRIAD.

- Patients must have a CT or MRI scan of the brain to evaluate for central nervous
system (CNS) disease within 42 days prior to sub-study registration. Patient must not
have leptomeningeal disease, spinal cord compression or brain metastases unless: (1)
metastases have been locally treated and have remained clinically controlled and
asymptomatic for at least 14 days following treatment, and prior to registration, AND
(2) patient has no residual neurological dysfunction and has been off corticosteroids
for at least 24 hours prior to sub-study registration.

- Patient must not have had a major surgery within 14 days prior to sub-study
registration. Patient must have fully recovered from the effects of prior surgery in
the opinion of the treating investigator.

- Absolute neutrophil count (ANC) >= 1,500/mcl (obtained within 28 days prior to
sub-study registration)

- Platelet count >= 100,000 mcl (obtained within 28 days prior to sub-study
registration)

- Hemoglobin >= 9 g/dL (obtained within 28 days prior to sub-study registration)

- Serum bilirubin =< Institutional Upper Limit of Normal (IULN). For patients with liver
metastases, bilirubin must be =< 5 x IULN (within 28 days prior to sub-study
registration)

- Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN
(if both ALT and AST are done, both must be < 2 IULN). For patients with liver
metastases, either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both
must be =< 5 x IULN) (within 28 days prior to sub-study registration)

- Patients must have a serum creatinine =< the IULN OR calculated creatinine clearance
>= 50 mL/min using the following Cockcroft-Gault Formula. This specimen must have been
drawn and processed within 28 days prior to sub-study registration.

- Patients must have Zubrod performance status 0-1 documented within 28 days prior to
sub-study registration.

- Patients must not have any Grade III/IV cardiac disease as defined by the New York
Heart Association Criteria (i.e., patients with cardiac disease resulting in marked
limitation of physical activity or resulting in inability to carry on any physical
activity without discomfort), unstable angina pectoris, and myocardial infarction
within 6 months, or serious uncontrolled cardiac arrhythmia.

- Pre-study history and physical exam must be obtained within 28 days prior to sub-study
registration.

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
Stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for five years.

- Patients must not be pregnant or nursing. Women/men of reproductive potential must
have agreed to use an effective contraceptive method during the study and 6 months
after study completion. A woman is considered to be of "reproductive potential" if she
has had menses at any time in the preceding 12 consecutive months. In addition to
routine contraceptive methods, "effective contraception" also includes heterosexual
celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy
prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal
ligation. However, if at any point a previously celibate patient chooses to become
heterosexually active during the time period for use of contraceptive measures
outlined in the protocol, he/she is responsible for beginning contraceptive measures
during the study and 6 months after study completion

- Patients must agree to have blood specimens submitted for circulating tumor DNA
(ctDNA).

- Patients must also be offered participation in banking and in the correlative studies
for collection and future use of specimens.
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Centralia, Washington 98531
Principal Investigator: Gary E. Goodman
Phone: 360-412-8958
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Centralia, WA
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Chattanooga, Tennessee 37404
Principal Investigator: Richard L. Deming
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14650 East Old US Highway 12
Chelsea, Michigan 48118
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Chelsea, MI
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775 South Main Street
Chelsea, Michigan 48118
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Chelsea, MI
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272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Principal Investigator: Timothy D. Moore
Phone: 877-779-7585
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Chillicothe, OH
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Cincinnati, Ohio 45220
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Cincinnati, OH
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Cincinnati, Ohio 45242
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Cincinnati, OH
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Cincinnati, Ohio 45247
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Cincinnati, OH
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Cincinnati, Ohio 45255
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Cincinnati, OH
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Clackamas, Oregon 97015
Principal Investigator: Gary E. Goodman
Phone: 503-215-2614
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Clackamas, OR
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9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
(503) 513-3300
Principal Investigator: Gary E. Goodman
Phone: 503-215-2614
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
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Clackamas, OR
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5680 Bow Pointe Drive
Clarkston, Michigan 48346
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Clarkston, MI
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31500 Telegraph Road
Clarkston, Michigan 48346
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Clarkston, MI
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Clinton, South Carolina 29325
Principal Investigator: Jeffrey K. Giguere
Phone: 864-241-6251
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Clinton, SC
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Clive, Iowa 50325
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Clive, IA
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12495 University Ave
Clive, Iowa 50325
(515) 358-9700
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
Mercy Cancer Center - West Lakes When it comes to cancer care, there
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Cody, Wyoming 82414
Principal Investigator: Benjamin T. Marchello
Phone: 800-996-2663
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Cody, WY
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Coeur d'Alene, Idaho 83814
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Coeur d'Alene, ID
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