Pembrolizumab Compared to Standard of Care Observation in Treating Patients With Completely Resected Stage I-III Merkel Cell Cancer



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:3/30/2019
Start Date:October 1, 2018
End Date:October 31, 2023

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A Phase III Randomized Trial Comparing Adjuvant MK-3475 (Pembrolizumab) to Standard of Care Observation in Completely Resected Merkel Cell Carcinoma

This phase III trial studies how well pembrolizumab works compared to standard of care
observation in treating patients with stage I-III Merkel cell cancer that has been completely
removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help
the body's immune system attack the cancer, and may interfere with the ability of tumor cells
to grow and spread.

PRIMARY OBJECTIVES:

I. To compare overall survival (OS) and recurrence free survival (RFS) as co-primary
endpoints across the two arms.

SECONDARY OBJECTIVES:

I. To evaluate adverse events. II. To evaluate distant metastasis free survival (DMFS). III.
To evaluate the impact of radiation on clinical outcomes (OS, RFS, DMFS).

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment
repeats every 21 days for up to 17 courses in the absence of disease progression or
unacceptable toxicity. Patients may also undergo standard of care radiation therapy within 14
days of day 1, course 1.

ARM B: Patients receive standard of care observation for 17 courses. Patients may also
undergo standard of care radiation therapy within 14 days of day 1, course 1.

After completion of study treatment, patients are followed up every 6 months for 4 years.

Inclusion Criteria:

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status: 0,
1, or 2 (Those patients who are wheel chair bound due to congenital or traumatic
events more than one year before the diagnosis of Merkel cell carcinoma may be
considered.)

- Women must not be pregnant or breast-feeding due to the unknown effects of the study
drug in this setting. All women of childbearing potential must have a blood test or
urine study within 2 weeks prior to registration to rule out pregnancy. A female of
childbearing potential is any woman, regardless of sexual orientation or whether they
have undergone tubal ligation, who meets the following criteria: 1) has achieved
menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy;
or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does
not rule out childbearing potential) for at least 24 consecutive months (i.e., has had
menses at any time in the preceding 24 consecutive months).

- Women of childbearing potential, if receiving MK-3475 (pembrolizumab) or radiation
therapy, and sexually active males must use an accepted and effective method of
contraception or to abstain from sex from time of registration, while on study
treatment, and continue for 120 days after the last dose of study treatment.

- Patient must have a histological confirmation of diagnosis of Merkel cell carcinoma
(MCC), pathologic stages (American Joint Committee on Cancer [AJCC] version 8) I-IIIb.

- Stage I patients with negative sentinel lymph node biopsy are ineligible.
Patients who have a positive biopsy or for whom no biopsy was done are eligible.

- Patients with distant metastatic disease (stage IV) are not eligible.

- The primary tumor must have negative margins.

- Patients with all macroscopic Merkel cell carcinoma (either identified by physical
exam or imaging) have been completely resected by surgery within 8 weeks before
enrollment.

- All patients must have disease-free status documented by a complete physical
examination and conventional imaging studies within 4 weeks prior to randomization.

- Patient must have no currently present metastases (as confirmed by standard imaging
studies).

- Patient must have no previous systemic therapy or radiation therapy for Merkel cell
carcinoma.

- Patients with inoperable disease who have received radiation are not eligible.

- White blood count >= 2000/uL (within 4 weeks prior to randomization).

- Absolute neutrophil count (ANC) >= 1000/Ul (within 4 weeks prior to randomization).

- Platelets >= 75 x 103/uL (within 4 weeks prior to randomization).

- Hemoglobin >= 8 g/dL (>= 80 g/L; may be transfused) (within 4 weeks prior to
randomization).

- Creatinine =< 2.0 x upper limit of normal (ULN) (within 4 weeks prior to
randomization).

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN (within 4
weeks prior to randomization).

- Total bilirubin =< 2.0 x ULN, (except patients with Gilbert's syndrome, who must have
a total bilirubin less than 3.0 mg/dL) (within 4 weeks prior to randomization).

- Patients who are human immunodeficiency virus (HIV)+ with undetectable HIV viral load
are eligible provided they meet all other protocol criteria for participation.

- Patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are
eligible provided viral loads are undetectable. Patients on suppressive therapy are
eligible.

- Patients must not be on active immunosuppression, have a history of life threatening
virus, have had other (beside non-melanoma skin cancers, or recent indolent cancers
e.g.: resected low grade prostate cancer) cancer diagnoses in the last two years, or
have had immunotherapy of any kind within the last 2 years.

- Patients must not have a history of (non-infectious) pneumonitis that required
steroids or has current pneumonitis.

- Operative notes from patient's surgical resection must be accessible.
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Methodist Medical Center of Illinois UnityPoint Health is one of the nation's most integrated health...
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Peoria, IL
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Peru, Illinois 61354
Principal Investigator: Bryan A. Faller
Phone: 815-664-4141
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Peru, IL
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4391 Venture Dr.
Peru, Illinois 61354
815-223-7010
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Peru Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Peru, IL
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Philadelphia, Pennsylvania 19103
Principal Investigator: Brian R. Gastman
Phone: 216-444-6901
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Philadelphia, PA
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111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Melissa A. Wilson
Phone: 215-955-6084
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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Philadelphia, PA
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Post Falls, Idaho 83854
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Post Falls, ID
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530 Park Ave East
Princeton, Illinois 61356
815-875-3010
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Princeton Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Princeton, IL
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Rice Lake, Wisconsin 54868
Principal Investigator: Rohit Sharma
Phone: 800-782-8581
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Rice Lake, WI
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3300 Oakdale Ave. N.
Robbinsdale, Minnesota 55422
763-520-5200
Principal Investigator: David M. King
Phone: 952-993-1517
North Memorial Medical Health Center North Memorial Health Care is a comprehensive health care system...
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Robbinsdale, MN
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Rochester, Minnesota 55905
Principal Investigator: Yiyi Yan
Phone: 855-776-0015
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Rochester, MN
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3015 North Ballas Road
Saint Louis, Missouri 63131
(314) 996-5000
Principal Investigator: Bryan A. Faller
Phone: 314-996-5569
Missouri Baptist Medical Center You just feel it. The smile that greets you. The hand...
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Saint Louis, MO
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Saint Louis, Missouri 63129
Principal Investigator: George Ansstas
Phone: 800-600-3606
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Saint Louis, MO
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