Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors



Status:Recruiting
Conditions:Gastroesophageal Reflux Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:1/12/2019
Start Date:September 6, 2018
End Date:January 2020
Contact:Ironwood Study Team
Email:IW3718@ironwoodpharma.com

Use our guide to learn which trials are right for you!

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients With Gastroesophageal Reflux Disease While Receiving Proton Pump Inhibitors

The objective of this study is to evaluate the safety and efficacy of IW-3718 administered to
patients with GERD who continue to have persistent symptoms, such as heartburn and
regurgitation, while receiving once-daily (QD), standarddose proton pump inhibitors (PPIs).


Inclusion Criteria:

Each patient must meet all of the following criteria to be eligible for enrollment in this
study:

- Patient is an ambulatory male or female (if female, nonpregnant) and is at least 18
years old at the Screening Visit.

- Patient has a diagnosis of GERD and reports experiencing GERD symptoms (heartburn or
regurgitation) while taking standard proton pump inhibitor (PPI) therapy.

- Patient has evidence of pathological acid reflux.

- Female patients must not be pregnant and must agree to avoid pregnancy for the
duration of the study.

- Patient must comply with study procedures.

Exclusion Criteria:

Patients who meet any of the following criteria will not be eligible to participate in the
study:

- Patient has a history of complete lack of GERD symptom response to PPI therapy.

- Patient has a significant medical or surgical history including conditions that would
impact drug absorption or metabolism (such as bowel obstruction, diabetes,
gastroparesis, hiatal hernia).

- Patient reports pain or burning behind the breastbone or in the center of the upper
stomach as his or her predominant symptom at the Screening Visit.

- Patient has received an investigational drug during the 30 days before the Screening
Visit, or is planning to receive another investigational drug or use an
investigational device at any time during the study.

NOTE: Other inclusion and exclusion criteria apply, per the study protocol.
We found this trial at
86
sites
Salt Lake City, Utah 84132
Phone: 801-581-2121
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Phone: 205-934-4154
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
5615 Kirby Dr.
Houston, Texas 77005
713-442-1223
?
mi
from
Houston, TX
Click here to add this to my saved trials
4085 University Blvd S # 1
Jacksonville, Florida 32216
Phone: 904-732-6683
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
6850 Coral Way # 409
Miami, Florida 33155
Phone: 305-667-8434
?
mi
from
Miami, FL
Click here to add this to my saved trials
400 Bald Hill Road
Warwick, Rhode Island 02886
401-739-9350
?
mi
from
Warwick, RI
Click here to add this to my saved trials
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
Phone: 316-689-6645
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Annapolis, Maryland 21401
Phone: 410-224-4887
?
mi
from
Annapolis, MD
Click here to add this to my saved trials
Asheville, North Carolina 28801
Phone: 828-254-0881
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
Phone: 225-927-1190
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Baytown, Texas 77512
Phone: 281-428-8203
?
mi
from
Baytown, TX
Click here to add this to my saved trials
Bridgewater, Nova Scotia
Phone: (902) 530-3216
?
mi
from
Bridgewater,
Click here to add this to my saved trials
Brockton, Massachusetts 02302
Phone: 508-588-9900
?
mi
from
Brockton, MA
Click here to add this to my saved trials
Bronx, New York 10468
Phone: 917-962-0234
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Brooklyn, New York 11235
Phone: 347-547-6972
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Canoga Park, California 91303
Phone: 818-999-4673
?
mi
from
Canoga Park, CA
Click here to add this to my saved trials
Carrollton, Texas 75010
Phone: 972-492-2776
?
mi
from
Carrollton, TX
Click here to add this to my saved trials
Chapel Hill, North Carolina 27514
Phone: 919-966-7074
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Charleston, South Carolina 29412
Phone: 843-795-1710
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Cincinnati, Ohio 45224
Phone: 513-681-0606
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
Phone: 216-778-5736
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Columbus, Ohio 43215
Phone: 614-487-2560
?
mi
from
Columbus, OH
Click here to add this to my saved trials
2020 Ponce de Leon Boulevard
Coral Gables, Florida 33134
Phone: 305-702-0024
?
mi
from
Coral Gables, FL
Click here to add this to my saved trials
Dayton, Ohio 45415
Phone: 937-320-5050
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Decatur, Georgia 30034
Phone: 770-987-7428
?
mi
from
Decatur, GA
Click here to add this to my saved trials
Dothan, Alabama 36305
Phone: 334-836-1055
?
mi
from
Dothan, AL
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Phone: 919-668-7924
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
415 East Yandell Drive
El Paso, Texas 79905
Phone: 915-215-5205
?
mi
from
El Paso, TX
Click here to add this to my saved trials
Elkridge, Maryland
Phone: 410-730-3399
?
mi
from
Elkridge, MD
Click here to add this to my saved trials
2510 Lakeland Drive
Flowood, Mississippi 39232
Phone: 601-863-0395
?
mi
from
Flowood, MS
Click here to add this to my saved trials
Franklin, Ohio 45005
Phone: 937-746-4505
?
mi
from
Franklin, OH
Click here to add this to my saved trials
Great Neck, New York 11023
Phone: 516-482-5976
?
mi
from
Great Neck, NY
Click here to add this to my saved trials
Greenville, North Carolina 27834
Phone: 252-758-8181
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Greenville, South Carolina 29615
Phone: 864-232-7338
?
mi
from
Greenville, SC
Click here to add this to my saved trials
20 Tower Court
Gurnee, Illinois 60031
Phone: 847-244-2960
?
mi
from
Gurnee, IL
Click here to add this to my saved trials
Hines, Illinois 60141
Phone: 708-202-2710
?
mi
from
Hines, IL
Click here to add this to my saved trials
Houston, Texas 77089
Phone: 281-944-3610
?
mi
from
Houston, TX
Click here to add this to my saved trials
Inverness, Florida 34452
Phone: 352-341-2100
?
mi
from
Inverness, FL
Click here to add this to my saved trials
Jackson, Tennessee 38305
Phone: 731-431-5027
?
mi
from
Jackson, TN
Click here to add this to my saved trials
33-57 Harrison Street
Johnson City, New York 13790
Phone: 607-798-7345
?
mi
from
Johnson City, NY
Click here to add this to my saved trials
Kansas City, Missouri 64128
Phone: 801-587-5597
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
Lancaster, California 93534
Phone: 661-388-2239
?
mi
from
Lancaster, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
Phone: 702-385-0046
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
4700 North State Road 7
Lauderdale Lakes, Florida 33319
Phone: 954-915-9991
?
mi
from
Lauderdale Lakes, FL
Click here to add this to my saved trials
Little Rock, Arkansas
Phone: 501-492-9175
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Little Rock, Arkansas 72211
Phone: 501-553-9987
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Loma Linda, California 92357
Phone: 909-825-7084
?
mi
from
Loma Linda, CA
Click here to add this to my saved trials
Lomita, California 90717
Phone: 310-373-8120
?
mi
from
Lomita, CA
Click here to add this to my saved trials
Miami, Florida 33135
Phone: 786-344-3845
?
mi
from
Miami, FL
Click here to add this to my saved trials
Mount Airy, North Carolina 27030
Phone: 336-415-5507
?
mi
from
Mount Airy, NC
Click here to add this to my saved trials
Mount Pleasant, South Carolina 29464
Phone: 843-856-2848
?
mi
from
Mount Pleasant, SC
Click here to add this to my saved trials
28078 Baxter Road
Murrieta, California 92563
Phone: 503-229-7137
?
mi
from
Murrieta, CA
Click here to add this to my saved trials
Nashville, Tennessee 37211
Phone: 615-835-4750
?
mi
from
Nashville, TN
Click here to add this to my saved trials
2630 Grant Line Road
New Albany, Indiana 47150
Phone: 812-206-1702
?
mi
from
New Albany, IN
Click here to add this to my saved trials
New Haven, Connecticut 06520
Phone: 203-737-6857
?
mi
from
New Haven, CT
Click here to add this to my saved trials
Norfolk, Virginia 23502
Phone: 757-466-0165
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
Norman, Oklahoma 73069
Phone: 405-329-0474
?
mi
from
Norman, OK
Click here to add this to my saved trials
North Charleston, South Carolina 29406
Phone: 843-725-5067
?
mi
from
North Charleston, SC
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
Phone: 405-602-3927
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
Phone: 405-271-5428
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
5804 Lake Underhill Road
Orlando, Florida 32807
Phone: 407-203-6898
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Peoria, Arizona 85381
Phone: 602-370-4691
?
mi
from
Peoria, AZ
Click here to add this to my saved trials
Peoria, Arizona 85381
Phone: 602-288-4673
?
mi
from
Peoria, AZ
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15243
Phone: 412-942-0010
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
?
mi
from
Portland, OR
Click here to add this to my saved trials
1939 Roland Clarke Place
Reston, Virginia 20191
Phone: 703-766-2650
?
mi
from
Reston, VA
Click here to add this to my saved trials
Richmond, Virginia
Phone: 804-308-8659
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Roswell, Georgia 30075
Phone: 770-645-7866
?
mi
from
Roswell, GA
Click here to add this to my saved trials
Saint Louis, Missouri 63110
Phone: 314-747-3969
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Salisbury, North Carolina 28144
Phone: 704-647-9913
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
1045 East 3900 South
Salt Lake City, Utah 84124
Phone: 415-408-8734
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
150 East Sonterra Boulevard
San Antonio, Texas 78229
Phone: 210-558-2794
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Diego, California 92103
Phone: 619-260-1012
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Pablo, California 94806
Phone: 415-408-8734
?
mi
from
San Pablo, CA
Click here to add this to my saved trials
Santa Ana, California 92703
Phone: 714-539-3013
?
mi
from
Santa Ana, CA
Click here to add this to my saved trials
Sayre, Pennsylvania 18840
Phone: 570-887-5415
?
mi
from
Sayre, PA
Click here to add this to my saved trials
Stamford, Connecticut 06095
Phone: 727-544-4842
?
mi
from
Stamford, CT
Click here to add this to my saved trials
Stockbridge, Georgia 30281
Phone: 770-507-6867
?
mi
from
Stockbridge, GA
Click here to add this to my saved trials
Syracuse, New York 13210
Phone: 315-425-4400
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
Topeka, Kansas 66614
Phone: 785-354-8518
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Troy, Michigan 48098
Phone: 248-267-6605
?
mi
from
Troy, MI
Click here to add this to my saved trials
Waukesha, Wisconsin 53186
Phone: 262-896-6346
?
mi
from
Waukesha, WI
Click here to add this to my saved trials
West Jordan, Utah 84088
Phone: 801-542-8190
?
mi
from
West Jordan, UT
Click here to add this to my saved trials
West Monroe, Louisiana 71291
Phone: 318-737-1095
?
mi
from
West Monroe, LA
Click here to add this to my saved trials
Wilmington, North Carolina 28403
Phone: 910-833-1954
?
mi
from
Wilmington, NC
Click here to add this to my saved trials
Wyoming, Michigan 49519
Phone: 616-608-8730
?
mi
from
Wyoming, MI
Click here to add this to my saved trials