Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)



Status:Active, not recruiting
Conditions:Bronchitis, Chronic Obstructive Pulmonary Disease, Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:45 - 80
Updated:6/27/2018
Start Date:November 2007
End Date:December 2022

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Genetic Epidemiology of Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused
by cigarette smoking. The purpose of this study is to evaluate whether certain genetic
factors predispose some smokers to develop COPD more than others.

COPD is a disease in which the lung airways are damaged and partly obstructed, making it
difficult to breathe. Millions of people in the United States have COPD, and it is the third
leading cause of death in the United States. Symptoms include coughing, excess mucus
production, shortness of breath, wheezing, and chest tightness. Emphysema and long-term
bronchitis are the two most common manifestations of the disease. The most common risk factor
for developing COPD is cigarette smoking; however, only 15% to 20% of smokers develop COPD in
their lifetimes. It is not known why some smokers develop COPD and some do not, but certain
genetic factors, combined with exposure to cigarette smoke, may increase the likelihood of
developing COPD. This study will analyze DNA from current and former cigarette smokers to
identify genetic factors and markers that may indicate a predisposition to developing COPD.

This study will enroll African-American and white cigarette smokers and former cigarette
smokers both with and without COPD. Participants will attend one study visit during which
they will complete questionnaires about lung symptoms, breathing difficulties, medical and
family history, and quality of life. They will also undergo blood collection, a physical
exam, lung function testing, and a walking test to measure endurance. Participants will
undergo a high resolution computed tomography (CT) chest scan and a medical record review.
Study researchers will contact participants up to four times a year for 5 years to collect
follow-up medical information. A five year follow-up visit including a similar study protocol
as the baseline visit will be performed on all available subjects.

Inclusion Criteria:

- At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also
being enrolled)

- Self-designation of non-Hispanic white or African-American

Exclusion Criteria:

- Other lung diseases (except for asthma in participants with COPD)

- Pregnant

- Cancer (other than skin cancer) in the 5 years prior to study entry

- Received antibiotics for a COPD exacerbation in the 1 month prior to study entry

- First- or second-degree relative of a previously enrolled study participant
We found this trial at
21
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Minneapolis, Minnesota 55440
Principal Investigator: Charlene McEvoy, MD
Phone: 952-967-5493
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Robert Wise, MD
Phone: 410-550-2449
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Mark Dransfield, MD
Phone: 205-996-6601
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Dawn DeMeo, MD
Phone: 617-525-2290
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Durham, North Carolina 27710
(919) 684-8111
Principal Investigator: Neil MacIntyre, MD
Phone: 919-613-6306
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Principal Investigator: Nicola Hanania, MD
Phone: 713-798-2683
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
Principal Investigator: Geoffrey McLennan, MD
Phone: 319-353-8862
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Chris Wendt, MD
Phone: 612-625-1435
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Principal Investigator: Frank Sciurba, MD
Phone: 412-623-5909
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Ann Arbor, Michigan 48105
Principal Investigator: Jeffrey Curtis, MD
Phone: 734-845-3533
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Fernando Martinez, MD
Phone: 855-303-5760
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Atlanta, Georgia
Principal Investigator: Marilyn Foreman, MD
Phone: 404-752-1877
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1400 Jackson St
Denver, Colorado 80206
(303) 388-4461
Principal Investigator: Russell Bowler, MD
Phone: 303-398-1772
National Jewish Health National Jewish Health is known worldwide for treatment of patients with respiratory,...
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Houston, Texas 77030
Principal Investigator: Amir Sharafkhaneh, MD
Phone: 713-794-7668
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Minneapolis, Minnesota 55417
Principal Investigator: Dennis Niewoehner, MD
Phone: 612-467-5203
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630 W 168th St
New York, New York
212-305-2862
Principal Investigator: R. Graham Barr, MD
Phone: 212-342-4162
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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1801 N Broad St
Philadelphia, Pennsylvania 19122
(215) 204-7000
Principal Investigator: Gerard Criner, MD
Phone: 215-707-2481
Temple University Temple University is many things to many people. A place to pursue life's...
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San Antonio, Texas 78229
Principal Investigator: Antonio Anzueto, MD
Phone: 210-949-3264
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San Diego, California 92093
Principal Investigator: Joe Ramsdell, MD
Phone: 619-471-0818
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Torrance, California 90502
Principal Investigator: Richard Casaburi, MD
Phone: 310-222-8200
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Worcester, Massachusetts 01608
Principal Investigator: Richard Rosiello, MD
Phone: 508-368-3929
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