A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia)



Status:Recruiting
Conditions:Anemia, Hematology
Therapuetic Areas:Hematology
Healthy:No
Age Range:18 - 55
Updated:1/18/2019
Start Date:January 26, 2018
End Date:June 2019
Contact:ShiYin Foo, MD PhD MMSc
Email:syfoo@imaratx.com
Phone:+1617-231-6721

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A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia)

A Phase 2a randomized, placebo-controlled, multicenter study of orally administered IMR-687
in adults with Sickle Cell Anaemia (SCA).

This is a proof of concept study in adult SCA patients, age 18-55 years old. The primary goal
is to examine the safety, pharmacokinetics and preliminary pharmacodynamics of escalating
doses of IMR-687 as compared to placebo.

Inclusion Criteria:

- Male or female patients with confirmed SCD

- Age 18-55 years, inclusive

- For patients on hydroxyurea, must have been on a stable dose for at least 60 days
prior to screening

Exclusion Criteria:

- Total hemoglobin >12.5 or less than 6 g/dL

- RBC transfusion within 60 days of baseline

- >7 hospitalizations for vasoocclusive crises within the last year

- eGFR < 50 ml/min

- AST/ALT > 3x the upper limit of normal
We found this trial at
9
sites
Atlanta, Georgia 30312
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Birmingham,
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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1200 West Harrison Stree
Chicago, Illinois 60607
(312) 996-4350
Univ of Illinois A major research university in the heart of one of the world's...
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Chicago, IL
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Chicago, Illinois 60644
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Chicago, IL
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263 Farmington Ave
Farmington, Connecticut 06032
Principal Investigator: Biree Andemariam, MD
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Farmington, CT
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1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
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Greenville, NC
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Hollywood, FL
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Oakland, California 94609
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Oakland, CA
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