Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Bladder Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:June 1, 2018
End Date:June 2020
Contact:Clovis Oncology Clinical Trial Navigation
Email:clovistrials@emergingmed.com
Phone:1-855-262-3040 (USA)

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A Phase 2, Open-label Study of Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

The purpose of the ATLAS study is to determine how patients with locally advanced
unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.


Inclusion Criteria:

- Have histologically or cytologically confirmed locally advanced unresectable or
metastatic transitional cell carcinoma of the urothelium (renal pelvis, ureter,
urinary bladder or urethra)

- Received 1 or 2 prior treatment regimens for advanced or metastatic disease

- Confirmed radiologic disease progression during or following recent treatment

- Mandatory biopsy is required during screening

- Measurable disease per RECIST v1.1

- Adequate organ function

- ECOG 0 or 1

Exclusion Criteria:

- Prior treatment with a PARP inhibitor

- Symptomatic and/or untreated CNS metastases

- Duodenal stent and/or any gastrointestinal disorder that may interfere with absorption
of rucaparib
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La Jolla, California 92093
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666 Elm Street
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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4805 Northeast Glisan Street
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(503) 215-1111
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Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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3181 Southwest Sam Jackson Park Road
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503 494-8311
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291 Campus Dr
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92 2nd St
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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