Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Bladder Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:June 1, 2018
End Date:June 2020
Contact:Clovis Oncology Clinical Trial Navigation
Email:clovistrials@emergingmed.com
Phone:1-855-262-3040 (USA)

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A Phase 2, Open-label Study of Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

The purpose of the ATLAS study is to determine how patients with locally advanced
unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.


Inclusion Criteria:

- Have histologically or cytologically confirmed locally advanced unresectable or
metastatic transitional cell carcinoma of the urothelium (renal pelvis, ureter,
urinary bladder or urethra)

- Received 1 or 2 prior treatment regimens for advanced or metastatic disease

- Confirmed radiologic disease progression during or following recent treatment

- Mandatory biopsy is required during screening

- Measurable disease per RECIST v1.1

- Adequate organ function

- ECOG 0 or 1

Exclusion Criteria:

- Prior treatment with a PARP inhibitor

- Symptomatic and/or untreated CNS metastases

- Duodenal stent and/or any gastrointestinal disorder that may interfere with absorption
of rucaparib
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Louisville, Kentucky 40202
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666 Elm Street
Buffalo, New York 14263
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
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Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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291 Campus Dr
Stanford, California 94305
(650) 725-3900
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Stanford University School of Medicine Vast in both its physical scale and its impact on...
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Albany, New York 12208
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Albuquerque, New Mexico 87102
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
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University of Michigan The University of Michigan was founded in 1817 as one of the...
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
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John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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80 Seymour Street
Hartford, Connecticut 06102
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9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
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1275 York Ave
New York, New York 10021
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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