Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Bladder Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:June 1, 2018
End Date:June 2020
Contact:Clovis Oncology Clinical Trial Navigation
Email:clovistrials@emergingmed.com
Phone:1-855-262-3040 (USA)

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A Phase 2, Open-label Study of Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

The purpose of the ATLAS study is to determine how patients with locally advanced
unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.


Inclusion Criteria:

- Have histologically or cytologically confirmed locally advanced unresectable or
metastatic transitional cell carcinoma of the urothelium (renal pelvis, ureter,
urinary bladder or urethra)

- Received 1 or 2 prior treatment regimens for advanced or metastatic disease

- Confirmed radiologic disease progression during or following recent treatment

- Mandatory biopsy is required during screening

- Measurable disease per RECIST v1.1

- Adequate organ function

- ECOG 0 or 1

Exclusion Criteria:

- Prior treatment with a PARP inhibitor

- Symptomatic and/or untreated CNS metastases

- Duodenal stent and/or any gastrointestinal disorder that may interfere with absorption
of rucaparib
We found this trial at
42
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Phone: 855-262-3040
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
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Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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291 Campus Dr
Stanford, California 94305
(650) 725-3900
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Stanford University School of Medicine Vast in both its physical scale and its impact on...
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Albany, New York 12208
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Albuquerque, New Mexico 87102
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Allentown, Pennsylvania 18105
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
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University of Michigan The University of Michigan was founded in 1817 as one of the...
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Baltimore, Maryland 21201
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Chattanooga, Tennessee 37403
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Chicago, Illinois 60611
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Dallas, Texas 76201
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Durham, North Carolina 27710
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 855-262-3040
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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80 Seymour Street
Hartford, Connecticut 06102
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Hershey, Pennsylvania 17033
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Houston, Texas 77030
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Indianapolis, Indiana 46202
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Iowa City, Iowa 52242
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La Jolla, California 92093
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Las Vegas, Nevada 89169
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Miami, Florida 33143
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9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
(414) 805-3666
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Froedtert and the Medical College of Wisconsin Froedtert Health combines with the Medical College of...
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Minneapolis, Minnesota 55404
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Myrtle Beach, South Carolina 29572
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Nashville, Tennessee 37209
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New Orleans, Louisiana 70121
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1275 York Ave
New York, New York 10021
(212) 639-2000
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, New York 10021
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Norwich, Connecticut 06360
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Oklahoma City, Oklahoma 73104
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Orange, California 92868
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Portland, Oregon 97062
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Salt Lake City, Utah 84112
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