Low GI Diet in Children and Adolescents With ALL



Status:Recruiting
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:5 - 21
Updated:4/17/2018
Start Date:June 1, 2017
End Date:June 2020
Contact:Betsy Ginn, RD
Email:erg2140@cumc.columbia.edu
Phone:6463172080

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Implementing a Low Glycemic Diet in Children and Adolescents Undergoing Treatment for Acute Lymphoblastic Leukemia

The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in
children and adolescents undergoing treatment for acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy with survival
exceeding 90%. However, treatment-related toxicity remains a clinical challenge during and
after treatment. Evidence-based, nutritional interventions may minimize the development of
nutrition-related toxicities, such as bone morbidities, hypertriglyceridemia, and obesity. To
date, no effective interventions are available to prevent nutrition-related morbidities in
children with ALL. Clinical studies evaluating the glycemic indices in other pediatric
conditions have been encouraging. It is plausible that reducing the glycemic indices of diets
during cancer treatment may have a profound clinical effect in this vulnerable pediatric
population. Prior to the design and implementation of randomized, controlled trials,
epidemiological data describing the Glycemic Index (GI) and Glycemic Load (GL) and the
association with clinically important outcomes is needed. Additionally, the feasibility of a
dietary intervention must also be explored within the setting of pediatric cancer. This study
aims to determine the feasibility, measured by compliance to a low-GI diet, of a 6-month low
glycemic dietary intervention in children and adolescents undergoing treatment for ALL. The
proposed work will be used for the design and implementation of a multi-center nutritional
intervention aimed at improving dietary intake during treatment and its effect on clinically
important outcomes. Importantly, the information will be used to drive the formation of
evidence-based nutritional guidelines for children with cancer, which will expand into the
emerging field of individualized medicine for patients with cancer.

Inclusion Criteria:

- Diagnosis of Acute Lymphoblastic Leukemia

- Within 5 days of starting the induction phase of treatment for Acute Lymphoblastic
Leukemia

- Proficient in English or Spanish

Exclusion Criteria:

- Diagnosis of relapsed Acute Lymphoblastic Leukemia

- Not meeting all of the inclusion criteria
We found this trial at
4
sites
Washington, District of Columbia 20010
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Buffalo, NY
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116th St and Broadway
New York, New York 10027
(212) 854-1754
Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
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New York, NY
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Philadelphia, PA
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