Myocardial Ischemia and Transfusion



Status:Recruiting
Conditions:Peripheral Vascular Disease, Cardiology, Cardiology, Anemia
Therapuetic Areas:Cardiology / Vascular Diseases, Hematology
Healthy:No
Age Range:18 - Any
Updated:9/12/2018
Start Date:April 25, 2017
End Date:April 2021
Contact:Jeffrey L Carson, MD
Email:Jeffrey.Carson@Rutgers.edu
Phone:732-235-7122

Use our guide to learn which trials are right for you!

The purpose of this study is to compare two red blood cell transfusion strategies (liberal
and restrictive) for patients who have had an acute myocardial infarction and are anemic.

In most clinical settings, evidence suggests it is safe to wait to give a blood transfusion.
However, for those who have suffered a heart attack, there is a lack of high quality evidence
to guide transfusions. This 3500 subject multi-center randomized trial will fill that void.

Hospital inpatients diagnosed with myocardial infarction who have blood counts less than 10
g/dL are randomized to receive either a liberal or a restrictive transfusion strategy.

Patients randomized to the liberal transfusion strategy will receive a red blood cell
transfusion anytime there is a blood count of less than 10 g/dL.

Patients randomized to the restrictive transfusion strategy are permitted to receive a blood
transfusion if the blood count is below 8 g/dL and the physician believes it is in the
patient's best interest. A transfusion will be strongly recommended if the blood count drops
to less than 7 g/dL. If the patient has symptoms of angina (e.g., chest discomfort described
as pressure or heaviness) that do not go away with medication, a blood transfusion is ordered
regardless of the blood count.

The transfusions strategies will be maintained until hospital discharge for a maximum of 30
days.

Patients will be followed for 30 days for clinically relevant outcomes. Vital status will be
confirmed at 180 days.

Inclusion Criteria:

- 18 years of age or older

- Either ST segment elevation myocardial infarction or Non ST segment elevation
myocardial infarction consistent with the 3rd Universal Definition of Myocardial
Infarction criteria that occurs on admission or during the index hospitalization

- Hemoglobin concentration less than 10 g/dL at the time of random allocation

- Patient physician believes that both of the transfusion strategies are consistent with
good medical care for the patient

Exclusion Criteria:

- Uncontrolled acute bleeding at the time of randomization defined as the need for
uncrossed or non-type specific blood

- Decline blood transfusion

- Scheduled for cardiac surgery during the current admission

- Receiving only palliative treatment

- Known that follow-up will not be possible at 30 days

- Previously participated in MINT

- Currently enrolled in a competing study that interferes with the intervention or
follow-up of MINT or enrolled in a competing study that has not been approved by the
local Institutional Review Board

- Patient physician does not believe the patient is an appropriate candidate for the
trial
We found this trial at
55
sites
500 S Preston St
Louisville, Kentucky
(502) 852-5555
Principal Investigator: Andrew DeFilippis, MD
University of Louisville The University of Louisville is a state supported research university located in...
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Louisville, KY
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Christopher Stowell, MD
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Boston, MA
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Lynn Uhl, MD
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Principal Investigator: Mark Menegus, MD
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Josehph Rossi, MD
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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Chapel Hill, NC
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: J. Dawn Abbott, MD
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Joseph Delehanty, MD
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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Rochester, NY
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47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Principal Investigator: Joshua Schulman-Marcus, MD
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
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Albany, NY
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Albuquerque, New Mexico 87131
(505) 277-0111
Principal Investigator: Warren K Laskey, MD
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Michael P Thomas, MD
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Bay Shore, New York 11706
Principal Investigator: Luis Gruberg, MD
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Boston, Massachusetts 02118
Principal Investigator: Omar Siddiqi, MD
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263 7th Avenue
Brooklyn, New York 11215
Principal Investigator: Sorin Brener, MD
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Burlington, Massachusetts 01805
Principal Investigator: Paolo Mascari, MD
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Burlington, Vermont 05405
Principal Investigator: Friederike Keating, MD
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Camden, New Jersey 08103
Principal Investigator: Perry Weinstock, MD
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Canton, Ohio 44710
Principal Investigator: Brendan Duffy, MD
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Raj C Shah, MD
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Chicago, IL
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Principal Investigator: Tamar Tamar, MD
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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Danbury, Connecticut 06810
Principal Investigator: Hal Wasserman, MD
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Duluth, Minnesota 55805
Principal Investigator: Wilson Ginete, MD
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Elk Grove Village, Illinois 60007
Principal Investigator: Paul Greunwald, MD
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Flushing, New York 11355
Principal Investigator: Xuming Dai, MD
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Flushing, NY
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Greenville, South Carolina 29615
Principal Investigator: Craig M Hudak, MD
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Gulfport, Mississippi 39502
Principal Investigator: Paul Mullen, MD
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Hackensack, New Jersey 07601
Principal Investigator: David Landers, MD
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Hawthorne, New York 10532
Principal Investigator: Howard Cooper, MD
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Hawthorne, NY
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Hinsdale, Illinois 60521
Principal Investigator: Meechai Tessalee, MD
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Hinsdale, IL
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Houston, Texas 77030
Principal Investigator: Arthur Bracey, MD
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4401 Wornall Road
Kansas City, Kansas 64111
Principal Investigator: Adam C Salisbury, MD
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Little Rock, Arkansas 72205
Principal Investigator: Barry Uretsky, MD
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Little Rock, Arkansas 72205
Principal Investigator: Srikanth Vallurupalli, MD
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Los Angeles, California 90073
Principal Investigator: Ramin Ebrahimi, MD
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1030 Jefferson Avenue
Memphis, Tennessee 38104
Principal Investigator: Kodangudi Ramanthan, MD
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Miami, Florida 33140
Principal Investigator: Lydia Howard, MD
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Milwaukee, Wisconsin 53226
Principal Investigator: Michael Gitter, MD
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2450 Riverside Ave
Minneapolis, Minnesota 55454
(612) 273-3000
Principal Investigator: Ganesh Raveendran, MD
University of Minnesota Medical Center, Fairview Improving patients' lives drives the innovation that makes University...
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Minneapolis, Minnesota 55407
Principal Investigator: Jay Traverse, MD
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1945 New Jersey 33
Neptune, New Jersey 08759
Principal Investigator: Michael Carson, MD
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New Brunswick, New Jersey 08903
Principal Investigator: Jeffrey L Carson, MD
Phone: 732-235-7122
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New Orleans, Louisiana 70112
Principal Investigator: Robert C Hendel, MD, FACC, FAHA, MASNC
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333 East 38th Street
New York, New York 10016
Principal Investigator: Norma Keller, MD
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Philadelphia, Pennsylvania 19104
Principal Investigator: William H Matthai, MD
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Gregary Marhefka, MD
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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200 Lothrop St
Pittsburgh, Pennsylvania 15213
Principal Investigator: Mark Schmidhofer, MD
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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164 Summit Ave
Providence, Rhode Island 02906
(401) 793-2500
Principal Investigator: Herbert Aronow, MD
Miriam Hospital The Miriam Hospital is a private, not-for-profit hospital, with a history of providing...
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Raleigh, North Carolina 27610
Principal Investigator: Frances Wood, MD
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Richmond, Virginia 23298
(804) 828-0100
Principal Investigator: Michael Kontos, MD
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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Rochester, Minnesota 55905
Principal Investigator: Gregory W Barsness, MD
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Rochester, New York 14621
Principal Investigator: Farhad Abtahian, MD
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Saint Louis, Missouri 63110
Principal Investigator: Richard Bach, MD
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1700 Hylan Boulevard
Staten Island, New York 10305
Principal Investigator: Gregory Maniatis, MD
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Stony Brook, New York 11794
Principal Investigator: William Lawson, MD
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Toledo, Ohio 43614
Principal Investigator: Ganesh Raveendran, MD
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Ypsilanti, Michigan 48197
Principal Investigator: Mansoor Qureshi, MD
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