A Study to Determine the Immunogenicity and Safety Profile of CSL Limited's Influenza Virus Vaccine Compared to a US Licensed Comparator Influenza Virus Vaccine

Inclusion Criteria:

1. Males aged ≥ 65 years or females of non-childbearing potential aged ≥ 65 years ;

2. Written informed consent ;

3. Willingness to provide a blood sample.

Exclusion Criteria:

1. Known hypersensitivity to a previous dose of influenza vaccine or allergy to eggs,
chicken protein, neomycin, polymyxin, or any components of the Study Vaccines;

2. Previous vaccination against influenza in 2008 or 2009 with seasonal trivalent
inactivated influenza vaccine;

3. Known history of Guillain-Barré Syndrome;

4. Clinical signs of active infection and/or an oral temperature of greater than or equal
to 100 degrees F (37.8 degrees C).

5. Have active or recent and clinically significant gastrointestinal/hepatic, renal,
neurological, cardiovascular, respiratory, endocrine disorders or other medical
disorders;

6. History of seizures;

7. Confirmed or suspected immunosuppressive condition, or a previously diagnosed
immunodeficiency disorder;

8. Clinically significant history of malignancy

9. Current treatment, or treatment with radiotherapy or cytotoxic drugs at any time
during the six months prior to administration of the Study Vaccine;

10. Current immunosuppressive or immunomodulative therapy;

11. Administration of immunoglobulins and/or any blood products within the 3 months
preceding the administration of the Study Vaccine;

12. Participation in a clinical trial or use of an investigational compound within 30 days
prior to receiving the Study Vaccine ;

13. Vaccination with a registered vaccine within 14 days (for inactivated vaccines) or 28
days (for live vaccines) prior to receiving the Study Vaccine.

14. Current treatment with warfarin or other anticoagulants;

15. Major congenital defects;

16. Evidence, or history (within the previous 12 months) of drug or alcohol abuse;

17. Unwillingness or inability to comply with the study protocol including completion of
adverse event diary cards;

18. History of psychiatric disorders;

19. Resident of long term care facility.