A Study of Nivolumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma



Status:Recruiting
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:July 11, 2017
End Date:April 22, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 3, Randomized, Open-Label Study of Nivolumab Combined With Cabozantinib Versus Sunitinib in Participants With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

The purpose of this study is to determine whether Nivolumab Combined with Cabozantinib is
safe and effective compared to Sunitinib in previously untreated advanced or metastatic renal
cell carcinoma


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histological confirmation of RCC with a clear-cell component, including participants
who may also have sarcomatoid features

- Advanced (not amenable to curative surgery or radiation therapy) or metastatic (AJCC
Stage IV) RCC

- No prior systemic therapy for RCC with the following exception:

i) One prior adjuvant or neoadjuvant therapy for completely resectable RCC if such
therapy did not include an agent that targets VEGF or VEGF receptors and if recurrence
occurred at least 6 months after the last dose of adjuvant or neoadjuvant therapy

Exclusion Criteria:

- Any active CNS metastases

- Any active, known or suspected autoimmune disease

- Any condition requiring systemic treatment with either corticosteroids (> 10 mg daily
prednisone equivalent) or other immunosuppressive medications within 14 days of
randomization

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
39
sites
Redondo Beach, California 90277
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Buffalo, NY
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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Allentown, Pennsylvania 18105
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Allentown, PA
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Phone: 734-763-8373
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Ann Arbor, MI
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Athens, GA
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Aurora, Colorado 80045
Phone: 720-848-0602
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Aurora, CO
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Austin, Texas 78731
Phone: 512-912-2761
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Austin, TX
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6501 Truxtun Avenue
Bakersfield, California 93309
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Bakersfield, CA
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Boston, Massachusetts 02111
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Boston, MA
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Chicago, IL
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Cincinnati, Ohio 45219
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Cincinnati, OH
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4190 Teniente General Juan Domingo Perón
Ciudad Autonoma De Buenos Aire, Buenos Aires C1199
Phone: +5491138018573
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Ciudad Autonoma De Buenos Aire,
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Dallas, Texas 75246
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Dallas, TX
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Daphne, Alabama 36526
Phone: 251-607-5283
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Daphne, AL
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Fort Wayne, Indiana 46845
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Fort Wayne, IN
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Goodyear, AZ
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Houston, Texas 77030
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Houston, TX
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Kansas City, Missouri 64132
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Kansas City, MO
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Phone: 702-952-1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Los Angeles, California 90095
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Los Angeles, California 90095
Phone: 310-206-4433
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Los Angeles, CA
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Midland, Texas 79701
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Midland, TX
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 646-888-1329
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Newnan, GA
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5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Phone: 757-213-5614
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
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Norfolk, VA
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Plano, Texas 75093
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Plano, TX
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Salt Lake City, Utah 84132
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San Luis Obispo, California 93401
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Santa Maria, California 93454
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Santa Maria, CA
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Seattle, Washington 98109
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Seattle, WA
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Sherman, Texas 75090
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Sherman, TX
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Tucson, Arizona 85724
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818 N. Emporia, #403
Wichita, Kansas 67214
(316) 262-4467
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
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Wichita, KS
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Zion, Illinois 60099
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