Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia



Status:Recruiting
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:Any
Updated:4/17/2018
Start Date:September 2016
End Date:March 2025
Contact:Jonathan Dillman, MD
Phone:513-736-2683

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The investigators plan to investigate the use of US shear wave elastography (SWE), a newly
available imaging technology, in children with suspected/known BA.

The investigators plan a prospective, multi-center study to determine if liver ultrasound
shear wave speed measurements acquired at clinical presentation can discriminate biliary
atresia (BA) from other causes of liver disease in the setting of neonatal cholestasis. The
investigators also plan to determine if liver ultrasound shear wave speed measurements
acquired at clinical presentation or longitudinally during the first one-year period after
Kasai can predict important long-term outcomes in BA patients.

Inclusion Criteria:

- neonatal cholestasis with concern for BA vs. other liver disease direct bilirubin >20%
of total or ≥2 mg/dL age <3 months

Exclusion Criteria:

- inability to obtain parent/guardian consent.

- inability to return for follow up visits as required by the study (these patients will
be included in aim 1, but will be unable to participate in aim 2).

- no other exclusion criteria.
We found this trial at
4
sites
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Principal Investigator: Jonathan Dillman, MD,MSc
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Ethan Smith, MD
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Columbus, Ohio 43205
Principal Investigator: Sally Smith, MD
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Stanford, California 94305
Principal Investigator: Richard Barth, MD
Phone: 650-725-2548
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Stanford, CA
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