A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/2/2019
Start Date:January 13, 2017
End Date:November 8, 2028
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

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Randomized, OpenLabel, Phase 3 Trial of Nivolumab Plus Ipilimumab or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Early Stage NSCLC

The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and
chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus
ipilimumab's safety and effectiveness in treating resectable NSCLC.

This study has multiple primary endpoints.

The first primary completion date of Pathological Complete Response is anticipated to be
reached April 2020.

The completion date for all primary outcome measures is expected May 2023.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Early stage IB-IIIA, operable non-small cell lung cancer, confirmed in tissue

- Lung function capacity capable of tolerating the proposed lung surgery

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1

- Available tissue of primary lung tumor

Exclusion Criteria:

- Presence of locally advanced, inoperable or metastatic disease

- Participants with active, known or suspected autoimmune disease

- Prior treatment with any drug that targets T cell co-stimulations pathways (such as
checkpoint inhibitors)

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
77
sites
Santa Barbara, California 93105
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Baltimore, Maryland 21231
410-955-6190
Phone: 410-502-8737
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
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Baltimore, MD
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Phone: 617-632-3468
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Phone: 260-969-7876
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
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Fort Wayne, IN
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-322-4967
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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24 Sturtevant St
Orlando, Florida 32806
Phone: 321-841-3812
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Orlando, FL
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Phone: 503-418-9389
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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1000 36th Street
Vero Beach, Florida 32960
Phone: 772-226-4960
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Athens, Georgia 30607
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Athens, GA
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Baltimore, Maryland 21237
Phone: 443-777-7364
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Bedford, Texas 76022
Phone: 817-359-9000
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Billings, Montana 59102
Phone: 406-238-6290
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Phone: 617-632-4767
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Burlington, Vermont 05405
Phone: 802-656-9916
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Capital Federal, Buenos Aires
Phone: +541132218956
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Charleston, South Carolina 29403
Phone: 843-577-6957
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-4421
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Phone: 773-702-1280
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, Illinois 60611
Phone: 312-695-4781
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2139 Auburn Ave
Cincinnati, Ohio 45219
(513) 585-2000
Phone: 513-451-4033
The Christ Hospital For more than 120 years, The Christ Hospital has been a leader...
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2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
Phone: 216-778-3526
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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Columbia, Missouri 65212
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Deerfield Beach, Florida 33442
Phone: 954-698-3616
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Denver, Colorado 80218
Phone: 303-285-5081
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Detroit, Michigan 48202
Phone: 313-916-0482
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El Paso, Texas 79920
Phone: 915-742-3432
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Elizabethtown, Kentucky 42701
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-208-3173
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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32 Washington Street
Fairhaven, Massachusetts 02719
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Fort Gordon, Georgia 30905
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Fort Worth, Texas 76164
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Fredericksburg, Virginia 22408
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Greenville, South Carolina 29601
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Hackensack, New Jersey
Phone: 551-996-8066
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Hattiesburg, Mississippi 39401
Phone: 601-288-2495
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High Point, North Carolina 27262
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Hollywood, Florida 33021
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Houston, Texas 77030
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Houston, Texas 77090
Phone: 877-870-2640
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Irving, Texas 75063
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Jacksonville, Florida 32256
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Lexington, Kentucky
859) 257-9000
Phone: 859-218-6145
University of Kentucky The University of Kentucky is a public, land grant university dedicated to...
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Los Angeles, California 90017
Phone: 213-977-1214
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Los Angeles, California 90095
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Louisville, Kentucky 40202
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Lubbock, Texas
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Marietta, Georgia 30060
Phone: 770-333-2161
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5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Phone: 801-507-3950
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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New Orleans, Louisiana 70112
Phone: 504-702-5171
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New York, New York 10016
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New York, New York 10016
Phone: 212-263-8696
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Niles, Illinois 60714
Phone: 847-827-9060
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Orlando, Florida 32804
Phone: 407-303-2523
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Philadelphia, Pennsylvania 19102
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Philadelphia, Pennsylvania 19111
Phone: 215-214-3789
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Phoenix, Arizona 85016
Phone: 602-277-4868
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Phoenix, Arizona 85016
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Pittsburgh, Pennsylvania 15240
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320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Phone: 412-578-1364
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
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Plainville, Connecticut
Phone: 860-224-4408
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Portland, Oregon 97201
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Sacramento, California 95819
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1506 South Silicon Way
Saint George, Utah 84770
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544 South 400 East
Saint George, Utah 84770
Phone: 435-688-4168
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Salt Lake City, Utah 84112
Phone: 801-587-4368
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Santa Rosa, California 95403
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Sherman, Texas 75090
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8007 183rd Street
Tinley Park, Illinois 60487
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721 Clinic Drive
Tyler, Texas 75701
Phone: 903-595-7045
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Waco, Texas 76712
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1 Valley Health Plaza
Westwood, New Jersey 07675
Phone: 201-634-5792
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Wichita, Kansas 67214
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Worcester, Massachusetts 01608
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740 Adair Avenue
Zanesville, Ohio 43701
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