An Investigational Immuno-therapy Study of Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based Chemotherapy



Status:Active, not recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/6/2018
Start Date:September 30, 2015
End Date:November 20, 2019

Use our guide to learn which trials are right for you!

A Randomized, Multicenter, Double-Blind, Phase 3 Study of Nivolumab, Nivolumab in Combination With Ipilimumab, or Placebo as Maintenance Therapy in Subjects With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based First Line Chemotherapy (CheckMate 451: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 451)

In this study, all patients must have already completed first-line chemotherapy to treat
extensive-stage disease small cell lung cancer. The purpose of this study is to show that
nivolumab, or nivolumab plus ipilimumab followed by nivolumab by itself, will prolong overall
survival when administered as consolidation treatment in patients that are stable or
responding after chemotherapy. Patients receiving treatment will be compared with patients
taking placebo.


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Subjects with histologically or cytologically confirmed extensive stage disease SCLC

- Ongoing response of stable disease or better following 4 cycles of platinum-based
first line chemotherapy

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Exclusion Criteria:

- Subjects with symptomatic Central Nervous System (CNS) metastases

- Subjects receiving consolidative chest radiation

- Subjects with active, known, or suspected autoimmune disease are excluded

- All side effects attributed to prior anti-cancer therapy must have resolved to Grade 1
or baseline
We found this trial at
29
sites
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Phone: 503-215-2699
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Durham, North Carolina 27710
(919) 684-8111
Phone: 919-681-4768
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
?
mi
from
Durham, NC
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
Allentown, Pennsylvania 18105
Phone: 610-402-1642
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Atlanta, Georgia 30322
Phone: 404-778-4582
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Baltimore, Maryland 21231
Phone: 443-287-9377
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Berazategui, Buenos Aires
?
mi
from
Berazategui,
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-8795
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Phone: 513-751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Phone: 614-366-6387
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
?
mi
from
Fairway, KS
Click here to add this to my saved trials
Fargo, North Dakota 58122
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Fort Myers, Florida 33916
Phone: 941-766-7222
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
Indianapolis, Indiana 46237
Phone: 317-782-7060
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32256
Phone: 904-825-4500
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Lexington, Kentucky 40503
Phone: 859-260-6406
?
mi
from
Lexington, KY
Click here to add this to my saved trials
New Haven, Connecticut 6520
(203) 432-4771
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 646-888-4203
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
?
mi
from
New York, NY
Click here to add this to my saved trials
Richmond, Virginia 23235
Phone: 804-288-7159
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Sacramento, California 95816
Phone: 916-445-6931
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-362-4140
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Saint Petersburg, Florida 33705
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Salt Lake City, Utah 84112
Phone: 801-585-7844
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Sayre, Pennsylvania 18840
Phone: 570-887-4882
?
mi
from
Sayre, PA
Click here to add this to my saved trials
Sioux Falls, South Dakota 57104
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
818 N. Emporia, #403
Wichita, Kansas 67214
(316) 262-4467
Phone: 316-268-8566
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Winston-Salem, North Carolina 27103
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials