Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery



Status:Suspended
Conditions:Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/12/2018
Start Date:July 30, 2015
End Date:January 30, 2022

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Randomized Phase II Study of Nivolumab With or Without Ipilimumab in Patients With Metastatic or Unresectable Sarcoma

This randomized phase II trial studies how well nivolumab with or without ipilimumab works in
treating patients with sarcoma that has spread from the primary site to other parts of the
body or cannot be removed by surgery. Monoclonal antibodies, such as nivolumab and
ipilimumab, may block tumor growth in different ways by targeting certain cells. It is not
yet known whether nivolumab works better with or without ipilimumab in treating patients with
metastatic or unresectable sarcoma.

PRIMARY OBJECTIVES:

I. To evaluate the confirmed response rate of single agent nivolumab and dual agent nivolumab
plus ipilimumab in patients with locally advanced/unresectable or metastatic soft tissue
sarcoma.

SECONDARY OBJECTIVES:

I. To evaluate adverse event rates (National Cancer Institute [NCI] Common Terminology
Criteria for Adverse Events [CTCAE] version [v]4.0) within each treatment arm.

II. To evaluate duration of response, clinical benefit rate, time to progression,
progression-free survival, and overall survival within each treatment arm.

TERTIARY OBJECTIVES:

I. To potentially detect an early signal of confirmed response rate within a histologically
defined patient cohort.

II. To assess the potential association between programmed cell death 1 ligand 1 (PD-L1)
expression (by immunohistochemistry [IHC]) and clinical outcome, within each treatment.

III. To evaluate associations between selected biomarker measured in serial peripheral blood
and with clinical efficacy, within each treatment.

IV. To evaluate the association between selected biomarker measured in tumor tissue with
clinical efficacy, within each treatment.

V. To evaluate the association between baseline tumor mutational burden and neoantigen
production with clinical efficacy within each treatment.

VI. To evaluate secondary endpoints within patients crossing over to dual agent nivolumab
plus ipilimumab after experiencing progressive disease while receiving single agent
nivolumab.

VII. To evaluate correlative science objectives endpoints within patients crossing over to
dual agent nivolumab plus ipilimumab after experiencing progressive disease while receiving
single agent nivolumab.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes once every 2 weeks.
Courses repeat every 42 days for up to 108 weeks in the absence of disease progression or
unacceptable toxicity. Patients who progress after 10 weeks on single agent nivolumab may
elect to cross over to Arm II.

ARM II: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 90 minutes once
every 3 weeks for 12 weeks. Patients then receive nivolumab IV over 30 minutes every 2 weeks.
Courses repeat every 42 days for up to 108 weeks in the absence of disease progression or
unacceptable toxicity. Patients who progress by imaging during the first 12 weeks of therapy
may continue treatment, at the discretion of the patient and treating investigator.

After completion of study treatment, patients are followed up at 4 weeks and then every 6
months for 3 years.

Inclusion Criteria:

- PRE-REGISTRATION ELIGIBILITY CRITERIA:

- Patients must have a formalin-fixed, paraffin-embedded (FFPE) tumor block OR 1
representative hematoxylin and eosin (H&E) and 20 unstained sarcoma tissue slides
available for submission to central pathology review; this review is mandatory prior
to registration to confirm eligibility

- REGISTRATION ELIGIBILITY CRITERIA:

- Patients must have histologically confirmed bone or soft tissue sarcoma by central
pathology review

- Patients must have histologically confirmed liposarcoma (LPS) (only
dedifferentiated and pleomorphic; well differentiated not eligible),
undifferentiated pleomorphic sarcoma (UPS)/malignant fibrous histiocytoma (MFH),
or gastrointestinal stromal tumor (GIST)

- Measurable disease

- Locally advanced/unresectable or metastatic disease

- >= 1 prior systemic therapy for sarcoma, including adjuvant systemic therapy

- No prior therapy with ipilimumab or nivolumab, or any agent targeting programmed cell
death 1 (PD-1), PD-L1 or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)

- No treatment with biologic therapy, immunotherapy, chemotherapy, investigational agent
for malignancy, or radiation =< 28 days before study registration; no treatment with
nitrosourea or mitomycin =< 42 days before study registration; for GIST, tyrosine
kinase inhibitor can be continued for up to 3 days prior to initiation of study
treatment

- Patients should have resolution of any toxic effects of prior therapy (except
alopecia) to NCI CTCAE, version 4.0, grade 1 or less

- No history of the following:

- Active known or suspected autoimmune disease

- Patients with human immunodeficiency virus (HIV) are eligible if the lymphocytes
> 350 cluster of differentiation (CD)4+ cells and no detectable viral load

- Symptomatic, untreated, or uncontrolled brain metastases present

- Active autoimmune colitis

- Autoimmune panhypopituitarism

- Autoimmune adrenal insufficiency

- Known active hepatitis B or C

- Hepatitis B can be defined as:

- Hepatitis B surface antigen (HBsAg) > 6 months

- Serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) 20,000 IU/ml
(105 copies/ml), lower values 2,000-20,000 IU/ml (104-105 copies/ml)
are often seen in hepatitis B e antigen (HBeAg)-negative chronic
hepatitis B

- Persistent or intermittent elevation in alanine aminotransferase
(ALT)/alanine aminotransferase (AST) levels

- Liver biopsy showing chronic hepatitis with moderate or severe
necroinflammation

- Hepatitis C can be defined as:

- Hepatitis C antibody (Ab) positive

- Presence of hepatitis C virus (HCV) ribonucleic acid (RNA)

- Known active pulmonary disease with hypoxia defined as:

- Oxygen saturation < 85% on room air or

- Oxygen saturation < 88% despite supplemental oxygen

- No systemic treatment with either corticosteroids (> 10 mg daily prednisone
equivalents) or other immunosuppressive medications within 14 days of registration

- Not pregnant and not nursing; for women of childbearing potential only, a negative
pregnancy test done =< 7 days prior to registration is required

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Absolute neutrophil count (ANC) >= 1,500/mm^3

- Platelet count >= 100,000/mm^3

- Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine
clearance > 45 mL/min using the lean body mass formula only

- Total bilirubin =< 1.5 x upper limit of normal (ULN) in absence of Gilbert disease
(total bilirubin =< 3 x ULN with Gilbert); also, if hyperbilirubinemia is clearly
attributed to liver metastases total bilirubin =< 3 x ULN is permitted

- AST/ALT =< 3 x upper limit of normal (ULN)

- Thyroid stimulating hormone (TSH) within normal limits (WNL); supplementation is
acceptable to achieve a TSH WNL; in patients with abnormal TSH if free T4 is normal
and patient is clinically euthyroid, patient is eligible

- Re-registration Eligibility Criteria (for patients who crossover from arm 1 nivolumab
alone to dual agent nivolumab and ipilimumab upon progression)

- Re-registration: measurable disease

- Re-registration: locally advanced/unresectable or metastatic disease

- Patient MUST have had progressive disease (radiographic or clinical) while on arm 1
single agent nivolumab while registered to A091401

- Patients removed from any immunotherapy for reasons other than progressive disease,
including arm 1 single agent nivolumab of A091401, are NOT eligible for
re-registration

- Patients must have completed a minimum of 10 weeks of single agent nivolumab on arm 1
of A091401 to be eligible for re-registration

- Patients must have completed study drug on arm 1 of A091401 (i.e., last dose of
nivolumab) =< 12 months of re-registration to crossover dual agent therapy

- No treatment with immunotherapy =< 21 days before re-registration; no treatment with
biologic therapy, chemotherapy, investigational agent for malignancy, or radiation =<
28 days before re-registration; no treatment with nitrosourea or mitomycin =< 42 days
before re-registration

- Patients should have resolution of any toxic effects of prior therapy (except fatigue
and alopecia) to NCI CTCAE, version 4.0, grade 1 or less, including immune toxicity

- No systemic treatment with either corticosteroids (> 10 mg daily prednisone
equivalents) or other immunosuppressive medications within 14 days of re-registration

- Not pregnant and not nursing; therefore, for women of childbearing potential only, a
negative pregnancy test done =< 7 days prior to re-registration is required

- ECOG performance status 0 or 1

- Re-registration: ANC >= 1,500/mm^3

- Re-registration: platelet count >= 100,000/mm^3

- Re-registration: creatinine =< 1.5 ULN OR calc. creatinine clearance > 45 mL/min
(using lean body mass formula only)

- Re-registration: total bilirubin =< 1.5 x ULN in absence of Gilbert disease (total
bilirubin =< 3 x ULN with Gilbert); if hyperbilirubinemia is clearly attributed to
liver metastases, total bilirubin =< 3 x ULN is permitted

- Re-registration: AST/ALT =< 3 x ULN

- Re-registration: TSH WNL; supplementation is acceptable to achieve a TSH WNL; in
patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid,
patient is eligible
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Burbank, California
Principal Investigator: Alison K. Conlin
Phone: 818-847-4793
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Burbank, CA
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Burien, Washington 98166
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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Burien, WA
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1501 Trousdale Drive
Burlingame, California 94010
Principal Investigator: Edmund W. Tai
Phone: 415-209-2686
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Burlingame, CA
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Burlington, Vermont 05405
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Burlington, VT
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Burlington, Wisconsin 53105
Principal Investigator: Manish K. Pant
Phone: 414-302-2304
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Burlington, WI
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201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Principal Investigator: Daniel M. Anderson
Phone: 952-993-1517
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
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Burnsville, MN
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400 South Clark Street
Butte, Montana 59701
406-723-2500
Principal Investigator: Keren Sturtz
Phone: 406-723-2621
Saint James Community Hospital and Cancer Treatment Center St. James Healthcare has played an important...
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Butte, MT
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3123 Medical Dr
Caldwell, Idaho 83605
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Caldwell, ID
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Camden, New Jersey 08103
Principal Investigator: Nati Lerman
Phone: 856-325-6757
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Camden, NJ
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Cameron Park, California 95682
Principal Investigator: Edmund W. Tai
Phone: 415-209-2686
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Cameron Park, CA
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210 W Walnut St
Canton, Illinois 61520
309-647-5240
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
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Canton, IL
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1600 South Canton Center Road
Canton, Michigan 48188
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Canton, MI
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1600 South Canton Center Road
Canton, Michigan 48188
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Canton, MI
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: Bryan A. Faller
Phone: 573-334-2230
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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Cape Girardeau, MO
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