RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix



Status:Archived
Conditions:Women's Studies
Therapuetic Areas:Reproductive
Healthy:No
Age Range:Any
Updated:7/1/2011

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A Randomized Trial of 17 Alpha-Hydroxyprogesterone Caproate for Prevention of Preterm Birth in Nulliparous Women With a Short Cervix


The purpose of this study is to see if giving progesterone medication to pregnant women, who
have never delivered a baby after 19 weeks of pregnancy and who have a short cervix, lowers
the risk of early delivery and improves the health of their baby.


Preterm births, defined as the delivery of a baby less than 37 weeks of gestation, are
responsible for the majority of neonatal mortality and morbidities. Studies have shown that
a number of risk factors, including never having a baby before and having a short cervix are
associated with early delivery. Recently the NICHD did a study in women who were pregnant
again after having delivered preterm. It showed that giving 17 alpha-hydroxyprogesterone
caproate (17P) medication during pregnancy decreased the chance of delivering another
preterm baby by 34%. This placebo-controlled randomized clinical trial will address the
primary research question: does treatment with 17P initiated before 23 weeks of gestation
prevent delivery prior to 37 weeks in nulliparous women with a singleton gestation who have
a short cervix?


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Salt Lake City, Utah 84132
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201 East Huron Street
Chicago, Illinois 60611
(847) 491-3741
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Birmingham, Alabama 35429
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101 Manning Dr
Chapel Hill, North Carolina 27599
(919) 966-4131
University of North Carolina Hospital at Chapel Hill The UNC Health Care System is a...
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Detroit, Michigan 48201
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1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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