Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Primary Hyperlipidemia or Mixed Dyslipidemia At Risk Of Cardiovascular Events



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:8/2/2018
Start Date:October 28, 2014
End Date:July 10, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A 52 Week Phase 3 Double-blind, Randomized, Placebo-controlled, Parallel-group Study To Assess The Efficacy, Safety And Tolerability Of Pf-04950615 In Subjects With Primary Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

This study is a multicenter, double-blind, randomized study to access the efficacy, safety
and tolerability of Bococizumab (PF-04950615; RN316) in subjects with hyperlipidemia
receiving background statin therapy.


Inclusion Criteria:

- Treated with a statin

- Fasting LDL-C >=100 mg/dL and triglyceride <= 400 mg/dL

- High or very high risk of incurring a cardiovascular event

Exclusion Criteria:

- Pregnant or breastfeeding females

- Cardiovascular or cerebrovascular event or procedure within 90 days

- Congestive heart failure NYHA class IV

- Poorly controlled hypertension
We found this trial at
107
sites
Physician's East
Greenville, North Carolina 27834
574
mi
from 02139
Greenville, NC
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Accord Clinical Research
3635 S. Clyde Morris Blvd
Port Orange, Florida 32129
386-760-3862
About Us Accord Clinical Research is a privately owned research facility, founded in Port Orange,...
1067
mi
from 02139
Port Orange, FL
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Millennium Clinical Trials, L.L.C.
3801 N. Fairfax Drive
Arlington, Virginia 22203
703-527-8100
395
mi
from 02139
Arlington, VA
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Millennium Clinical Trials, L.L.C.
3801 N. Fairfax Drive
Arlington, Virginia 22203
703-527-8100
395
mi
from 02139
Arlington, VA
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Renstar Medical Research
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
1098
mi
from 02139
Ocala, FL
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Clinical Trials of Texas, Inc.
7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
1763
mi
from 02139
San Antonio, TX
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Clinical Trials of Texas, Inc.
7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
1763
mi
from 02139
San Antonio, TX
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Spartanburg Medical Research
485 Simuel Road.
Spartanburg, South Carolina 29303
(864) 583-1556
776
mi
from 02139
Spartanburg, SC
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Castlerock Clinical Research Consultants, LLC
6804 South Canton
Tulsa, Oklahoma 74136
918-524-5205
1392
mi
from 02139
Tulsa, OK
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Heartland Research Associates, LLC
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
1414
mi
from 02139
Wichita, KS
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Heartland Research Associates, LLC
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
1414
mi
from 02139
Wichita, KS
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Albuquerque Clinical Trials
Albuquerque, New Mexico
1965
mi
from 02139
Albuquerque, NM
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Advanced Cardiovascular, LLC Research
Alexander City, Alabama 35010
1038
mi
from 02139
Alexander City, AL
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Advanced Cardiovascular, LLC, Research
Auburn, Alabama 36830
1034
mi
from 02139
Auburn, AL
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Heartland Research Associates, LLC
Augusta, Kansas 67010
1400
mi
from 02139
Augusta, KS
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University of Colorado Hospital
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
1754
mi
from 02139
Aurora, CO
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American Health Network Of Indiana Llc
Avon, Indiana 46123
815
mi
from 02139
Avon, IN
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Bethesda Health Research
Bethesda, Maryland 20817
392
mi
from 02139
Bethesda, MD
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BRCR Medical Center, Inc.
Boca Raton, Florida 33432
1218
mi
from 02139
Boca Raton, FL
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Boca Raton Clinical Research Associates
Boca Raton, Florida 33432
1217
mi
from 02139
Boca Raton, FL
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Northwest Clinical Trials
Boise, Idaho 83704
2256
mi
from 02139
Boise, ID
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Meridien Research
Brooksville, Florida
1143
mi
from 02139
Brooksville, FL
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LMC Clinical Research Inc. (Calgary)
Calgary, Alberta
2089
mi
from 02139
Calgary,
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Punzi Medical Center
Carrollton, Texas 75006
1544
mi
from 02139
Carrollton, TX
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Medical Research South
Charleston, South Carolina 29407
820
mi
from 02139
Charleston, SC
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Clinical Research Advantage, Inc. / Colorado Springs Family Practice
Colorado Springs, Colorado 80909
1773
mi
from 02139
Colorado Springs, CO
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Ellipsis Research Group, LLC
Columbia, South Carolina 29201
789
mi
from 02139
Columbia, SC
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Linfritz Research Institute Inc.
Coral Gables, Florida 33134
1259
mi
from 02139
Coral Gables, FL
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Primed Clinical Research
Dayton, Ohio 45419
704
mi
from 02139
Dayton, OH
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Creekside Endocrine Associates PC
Denver, Colorado 80209
1762
mi
from 02139
Denver, CO
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Centennial Medical Group
Elkridge, Maryland
366
mi
from 02139
Elkridge, MD
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McLaren Flint
Flint, Michigan 48532
638
mi
from 02139
Flint, MI
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Florida Health Center
Fort Lauderdale, Florida 33312
1236
mi
from 02139
Fort Lauderdale, FL
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Clinical Research Advantage, Inc./Prairie Fields Family Medicine, PC
Fremont, Nebraska 68025
1302
mi
from 02139
Fremont, NE
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Stern Cardiovascular Foundation
Germantown, Tennessee 38138
1122
mi
from 02139
Germantown, TN
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Physician's East
Greenville, North Carolina 27834
574
mi
from 02139
Greenville, NC
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Physician's East Endocrinology
Greenville, North Carolina 27834
574
mi
from 02139
Greenville, NC
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Harleysville Medical Associates
Harleysville, Pennsylvania 19438
264
mi
from 02139
Harleysville, PA
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Health Care Family Rehab & Research Center
Hialeah, Florida 33012
1255
mi
from 02139
Hialeah, FL
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Indago Research & Health Center, Inc.
Hialeah, Florida 33012
1253
mi
from 02139
Hialeah, FL
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Clinical Trials of America Inc
Hickory, North Carolina 28601
712
mi
from 02139
Hickory, NC
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PMG Research of Hickory, LLC
Hickory, North Carolina 28602
714
mi
from 02139
Hickory, NC
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Catawba Valley Medical Group, Inc.
Hickory, North Carolina 28601
714
mi
from 02139
Hickory, NC
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Gulf Coast Medical Research, LLC
Houston, Texas 77025
1608
mi
from 02139
Houston, TX
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Office of Michelle Zaniewski MD., PA.
Houston, Texas 77090
1594
mi
from 02139
Houston, TX
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Juno Research
Houston, Texas 77074
1611
mi
from 02139
Houston, TX
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Apex Cardiology
Jackson, Tennessee 38301
1056
mi
from 02139
Jackson, TN
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Research Associates of Jackson
Jackson, Tennessee 38301
1056
mi
from 02139
Jackson, TN
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Juno Research, LLC
Katy, Texas 77450
1621
mi
from 02139
Katy, TX
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Clinical Investigation Specialists
Kenosha, Wisconsin 53142
853
mi
from 02139
Kenosha, WI
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PMG Research Inc. d/b/a PMG Research of Knoxville
Knoxville, Tennessee 37912
815
mi
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Knoxville, TN
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Imperial Health, LLP
Lake Charles, Louisiana 70601
1483
mi
from 02139
Lake Charles, LA
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Lynn Institute of the Ozarks
Little Rock, Arkansas 72205
1257
mi
from 02139
Little Rock, AR
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The Office of Larry Watkins, MD
Little Rock, Arkansas 72205
1258
mi
from 02139
Little Rock, AR
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The American Institute of Research
Los Angeles, California 90017
2598
mi
from 02139
Los Angeles, CA
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IMD Medical Group
Los Angeles, California 90020
2591
mi
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Los Angeles, CA
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lntermed Group
Los Angeles, California 90017
2588
mi
from 02139
Los Angeles, CA
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HFM Heart and Vascular Center/Holy Family Memorial, Inc
Manitowoc, Wisconsin 54220
840
mi
from 02139
Manitowoc, WI
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Crescent City Clinical Research Center
Metairie, Louisiana 70006
1357
mi
from 02139
Metairie, LA
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Sunrise Research Institute, Inc
Miami, Florida 33130
1257
mi
from 02139
Miami, FL
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Prestige Clinical Research Center Inc.
Miami, Florida 33125
1260
mi
from 02139
Miami, FL
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Elite Clinical Research
Miami, Florida 33144
1260
mi
from 02139
Miami, FL
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Columbus Clinical Services, LLC
Miami, Florida 33174
1260
mi
from 02139
Miami, FL
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The Research Specialists of Florida, Inc.
Miami, Florida 33162
1246
mi
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Miami, FL
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Advanced Clinical Research of Miami
Miami, Florida 33155
1262
mi
from 02139
Miami, FL
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Suncoast Research Group, LLD
2128 West Flagler Street
Miami, Florida 33135
1257
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Miami, FL
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NewPhase Clinical Trials, Corp.
Miami Beach, Florida 33140
1252
mi
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Miami Beach, FL
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Panax Clinical Research
Miami Lakes, Florida 33014
1251
mi
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Miami Lakes, FL
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Precision Research Organization
Miami Lakes, Florida 33016
1251
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Miami Lakes, FL
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First Quality
Miramar, Florida 33025
1245
mi
from 02139
Miramar, FL
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Gulf Coast Medical Research,LLC
Missouri City, Texas 77459
1621
mi
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Missouri City, TX
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Clinical Trials of America LA, LLC
Monroe, Louisiana 71203
1333
mi
from 02139
Monroe, LA
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National Clinical Research - Norfolk, Inc.
Norfolk, Virginia 23502
467
mi
from 02139
Norfolk, VA
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The Office of Lucita M. Cruz, M.D., Inc.
Norwalk, California 90650
2584
mi
from 02139
Norwalk, CA
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American Family Medical
Ocala, Florida 34471
1099
mi
from 02139
Ocala, FL
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South Oklahoma Heart Research
Oklahoma City, Oklahoma 73135
1488
mi
from 02139
Oklahoma City, OK
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Aspen Clinical Research, LLC
Orem, Utah 84058
2091
mi
from 02139
Orem, UT
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Pines Care Research Center, LLC
Pembroke Pines, Florida 33026
1243
mi
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Pembroke Pines, FL
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DBC Research USA
Pembroke Pines, Florida 33029
1244
mi
from 02139
Pembroke Pines, FL
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Andres Patron, D.O.P.A.
10796 Pines Boulevard
Pembroke Pines, Florida 33026
1244
mi
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Pembroke Pines, FL
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The Office of Daniel G. Williams, MD
Perrysburg, Ohio 43551
645
mi
from 02139
Perrysburg, OH
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Clinical Research Advantage, Inc./ Family Practice Specialists, Ltd.
Phoenix, Arizona 85018
2285
mi
from 02139
Phoenix, AZ
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Riser Medical Research
Picayune, Mississippi 39466
1312
mi
from 02139
Picayune, MS
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Clinical Research Advantage, Inc./ Plano Internal Medicine Associates
Plano, Texas 75093
1533
mi
from 02139
Plano, TX
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Progressive Medical Research
Port Orange, Florida 32127
1068
mi
from 02139
Port Orange, FL
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Sound Health Care Center
Port Orchard, Washington 98366
2494
mi
from 02139
Port Orchard, WA
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Sound Medical Research
Port Orchard, Washington 98366
2498
mi
from 02139
Port Orchard, WA
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ActivMed Practices & Research, Inc.
Portsmouth, New Hampshire 03801
51
mi
from 02139
Portsmouth, NH
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Wake Internal Medicine Consultants, Inc.
Raleigh, North Carolina 27612
607
mi
from 02139
Raleigh, NC
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Wake Research Associates, LLC
3100 Duraleigh Rd
Raleigh, North Carolina 27612
(919) 781-2514
Wake Research Associates, LLC Wake Research is an Organization of Unified Investigational Sites working closely...
606
mi
from 02139
Raleigh, NC
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Superior Research LLC
Sacramento, California 95825
2622
mi
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Sacramento, CA
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East Coast Institute for RSCH, St. Augustine Cardiology Associates, Research
Saint Augustine, Florida 32086
1039
mi
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Saint Augustine, FL
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East Coast Institute for Research, LLC/ Baker-Gilmour Cardiovascular Institute
Saint Augustine, Florida 32086
1031
mi
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Saint Augustine, FL
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CentraCare Heart & Vascular Center @ St. Cloud Hospital
1406 6th Avenue North
Saint Cloud, Minnesota 56303
1163
mi
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Saint Cloud, MN
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Washington University Center for Advanced Medicine
4921 Parkview Place
Saint Louis, Missouri 63110
1036
mi
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Saint Louis, MO
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1036
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Saint Louis, MO
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Meridien Research
Saint Petersburg, Florida 33709
1199
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Saint Petersburg, FL
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Radiant Research
Santa Rosa, California 95405
2685
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Santa Rosa, CA
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Cardiovascular Center of Sarasota
Sarasota, Florida 34239
1222
mi
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Sarasota, FL
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Gulf Coast Medical Research, LLC
2225 Williams Trace Boulevard
Sugar Land, Texas 77478
1620
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Sugar Land, TX
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Meridien Research
Tampa, Florida
1182
mi
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Tampa, FL
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