Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Primary Hyperlipidemia or Mixed Dyslipidemia At Risk Of Cardiovascular Events



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:8/2/2018
Start Date:October 28, 2014
End Date:July 10, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A 52 Week Phase 3 Double-blind, Randomized, Placebo-controlled, Parallel-group Study To Assess The Efficacy, Safety And Tolerability Of Pf-04950615 In Subjects With Primary Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

This study is a multicenter, double-blind, randomized study to access the efficacy, safety
and tolerability of Bococizumab (PF-04950615; RN316) in subjects with hyperlipidemia
receiving background statin therapy.


Inclusion Criteria:

- Treated with a statin

- Fasting LDL-C >=100 mg/dL and triglyceride <= 400 mg/dL

- High or very high risk of incurring a cardiovascular event

Exclusion Criteria:

- Pregnant or breastfeeding females

- Cardiovascular or cerebrovascular event or procedure within 90 days

- Congestive heart failure NYHA class IV

- Poorly controlled hypertension
We found this trial at
107
sites
Wake Research Associates, LLC
3100 Duraleigh Rd
Raleigh, North Carolina 27612
(919) 781-2514
Wake Research Associates, LLC Wake Research is an Organization of Unified Investigational Sites working closely...
2214
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from 91732
Raleigh, NC
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Accord Clinical Research
3635 S. Clyde Morris Blvd
Port Orange, Florida 32129
386-760-3862
About Us Accord Clinical Research is a privately owned research facility, founded in Port Orange,...
2190
mi
from 91732
Port Orange, FL
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Millennium Clinical Trials, L.L.C.
3801 N. Fairfax Drive
Arlington, Virginia 22203
703-527-8100
2277
mi
from 91732
Arlington, VA
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Millennium Clinical Trials, L.L.C.
3801 N. Fairfax Drive
Arlington, Virginia 22203
703-527-8100
2277
mi
from 91732
Arlington, VA
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Renstar Medical Research
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
2126
mi
from 91732
Ocala, FL
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Clinical Trials of Texas, Inc.
7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
1182
mi
from 91732
San Antonio, TX
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Clinical Trials of Texas, Inc.
7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
1182
mi
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San Antonio, TX
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Spartanburg Medical Research
485 Simuel Road.
Spartanburg, South Carolina 29303
(864) 583-1556
2040
mi
from 91732
Spartanburg, SC
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Castlerock Clinical Research Consultants, LLC
6804 South Canton
Tulsa, Oklahoma 74136
918-524-5205
1254
mi
from 91732
Tulsa, OK
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Heartland Research Associates, LLC
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
1186
mi
from 91732
Wichita, KS
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Heartland Research Associates, LLC
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
1186
mi
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Wichita, KS
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Albuquerque Clinical Trials
Albuquerque, New Mexico
649
mi
from 91732
Albuquerque, NM
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Advanced Cardiovascular, LLC Research
Alexander City, Alabama 35010
1840
mi
from 91732
Alexander City, AL
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Advanced Cardiovascular, LLC, Research
Auburn, Alabama 36830
1872
mi
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Auburn, AL
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Heartland Research Associates, LLC
Augusta, Kansas 67010
1201
mi
from 91732
Augusta, KS
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University of Colorado Hospital
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
825
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Aurora, CO
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American Health Network Of Indiana Llc
Avon, Indiana 46123
1780
mi
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Avon, IN
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Bethesda Health Research
Bethesda, Maryland 20817
2275
mi
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Bethesda, MD
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BRCR Medical Center, Inc.
Boca Raton, Florida 33432
2313
mi
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Boca Raton, FL
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Boca Raton Clinical Research Associates
Boca Raton, Florida 33432
2312
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Boca Raton, FL
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Northwest Clinical Trials
Boise, Idaho 83704
666
mi
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Boise, ID
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Meridien Research
Brooksville, Florida
2126
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Brooksville, FL
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LMC Clinical Research Inc. (Calgary)
Calgary, Alberta
1189
mi
from 91732
Calgary,
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Punzi Medical Center
Carrollton, Texas 75006
1217
mi
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Carrollton, TX
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Medical Research South
Charleston, South Carolina 29407
2180
mi
from 91732
Charleston, SC
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Clinical Research Advantage, Inc. / Colorado Springs Family Practice
Colorado Springs, Colorado 80909
802
mi
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Colorado Springs, CO
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Ellipsis Research Group, LLC
Columbia, South Carolina 29201
2105
mi
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Columbia, SC
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Linfritz Research Institute Inc.
Coral Gables, Florida 33134
2318
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Coral Gables, FL
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Primed Clinical Research
Dayton, Ohio 45419
1897
mi
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Dayton, OH
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Creekside Endocrine Associates PC
Denver, Colorado 80209
818
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Denver, CO
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Centennial Medical Group
Elkridge, Maryland
2296
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Elkridge, MD
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McLaren Flint
Flint, Michigan 48532
1940
mi
from 91732
Flint, MI
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Florida Health Center
Fort Lauderdale, Florida 33312
2314
mi
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Fort Lauderdale, FL
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Clinical Research Advantage, Inc./Prairie Fields Family Medicine, PC
Fremont, Nebraska 68025
1276
mi
from 91732
Fremont, NE
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Stern Cardiovascular Foundation
Germantown, Tennessee 38138
1600
mi
from 91732
Germantown, TN
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Physician's East
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
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Physician's East
Greenville, North Carolina 27834
2290
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Greenville, NC
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Physician's East Endocrinology
Greenville, North Carolina 27834
2290
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Greenville, NC
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Harleysville Medical Associates
Harleysville, Pennsylvania 19438
2362
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Harleysville, PA
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Health Care Family Rehab & Research Center
Hialeah, Florida 33012
2315
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Hialeah, FL
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Indago Research & Health Center, Inc.
Hialeah, Florida 33012
2313
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Hialeah, FL
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Clinical Trials of America Inc
Hickory, North Carolina 28601
2069
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Hickory, NC
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PMG Research of Hickory, LLC
Hickory, North Carolina 28602
2069
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Hickory, NC
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Catawba Valley Medical Group, Inc.
Hickory, North Carolina 28601
2069
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Hickory, NC
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Gulf Coast Medical Research, LLC
Houston, Texas 77025
1356
mi
from 91732
Houston, TX
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Office of Michelle Zaniewski MD., PA.
Houston, Texas 77090
1348
mi
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Houston, TX
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Juno Research
Houston, Texas 77074
1351
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Houston, TX
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Apex Cardiology
Jackson, Tennessee 38301
1653
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Jackson, TN
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Research Associates of Jackson
Jackson, Tennessee 38301
1652
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Jackson, TN
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Juno Research, LLC
Katy, Texas 77450
1331
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Katy, TX
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Clinical Investigation Specialists
Kenosha, Wisconsin 53142
1724
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Kenosha, WI
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PMG Research Inc. d/b/a PMG Research of Knoxville
Knoxville, Tennessee 37912
1923
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Knoxville, TN
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Imperial Health, LLP
Lake Charles, Louisiana 70601
1469
mi
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Lake Charles, LA
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Lynn Institute of the Ozarks
Little Rock, Arkansas 72205
1460
mi
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Little Rock, AR
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The Office of Larry Watkins, MD
Little Rock, Arkansas 72205
1459
mi
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Little Rock, AR
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The American Institute of Research
Los Angeles, California 90017
24
mi
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Los Angeles, CA
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IMD Medical Group
Los Angeles, California 90020
16
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Los Angeles, CA
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lntermed Group
Los Angeles, California 90017
13
mi
from 91732
Los Angeles, CA
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HFM Heart and Vascular Center/Holy Family Memorial, Inc
Manitowoc, Wisconsin 54220
1756
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Manitowoc, WI
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Crescent City Clinical Research Center
Metairie, Louisiana 70006
1652
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Metairie, LA
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Sunrise Research Institute, Inc
Miami, Florida 33130
2321
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Miami, FL
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Prestige Clinical Research Center Inc.
Miami, Florida 33125
2320
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Miami, FL
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Elite Clinical Research
Miami, Florida 33144
2315
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Miami, FL
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Columbus Clinical Services, LLC
Miami, Florida 33174
2320
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Miami, FL
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The Research Specialists of Florida, Inc.
Miami, Florida 33162
2318
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Miami, FL
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Advanced Clinical Research of Miami
Miami, Florida 33155
2316
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Miami, FL
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Suncoast Research Group, LLD
2128 West Flagler Street
Miami, Florida 33135
2319
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Miami, FL
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NewPhase Clinical Trials, Corp.
Miami Beach, Florida 33140
2324
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Miami Beach, FL
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Panax Clinical Research
Miami Lakes, Florida 33014
2311
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Miami Lakes, FL
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Precision Research Organization
Miami Lakes, Florida 33016
2311
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Miami Lakes, FL
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First Quality
Miramar, Florida 33025
2311
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Miramar, FL
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Gulf Coast Medical Research,LLC
Missouri City, Texas 77459
1355
mi
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Missouri City, TX
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Clinical Trials of America LA, LLC
Monroe, Louisiana 71203
1495
mi
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Monroe, LA
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National Clinical Research - Norfolk, Inc.
Norfolk, Virginia 23502
2341
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Norfolk, VA
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The Office of Lucita M. Cruz, M.D., Inc.
Norwalk, California 90650
12
mi
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Norwalk, CA
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American Family Medical
Ocala, Florida 34471
2127
mi
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Ocala, FL
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South Oklahoma Heart Research
Oklahoma City, Oklahoma 73135
1170
mi
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Oklahoma City, OK
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Aspen Clinical Research, LLC
Orem, Utah 84058
551
mi
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Orem, UT
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Pines Care Research Center, LLC
Pembroke Pines, Florida 33026
2309
mi
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Pembroke Pines, FL
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DBC Research USA
Pembroke Pines, Florida 33029
2309
mi
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Pembroke Pines, FL
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Andres Patron, D.O.P.A.
10796 Pines Boulevard
Pembroke Pines, Florida 33026
2310
mi
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Pembroke Pines, FL
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The Office of Daniel G. Williams, MD
Perrysburg, Ohio 43551
1932
mi
from 91732
Perrysburg, OH
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Clinical Research Advantage, Inc./ Family Practice Specialists, Ltd.
Phoenix, Arizona 85018
349
mi
from 91732
Phoenix, AZ
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Riser Medical Research
Picayune, Mississippi 39466
1667
mi
from 91732
Picayune, MS
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Clinical Research Advantage, Inc./ Plano Internal Medicine Associates
Plano, Texas 75093
1227
mi
from 91732
Plano, TX
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Progressive Medical Research
Port Orange, Florida 32127
2194
mi
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Port Orange, FL
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Sound Health Care Center
Port Orchard, Washington 98366
966
mi
from 91732
Port Orchard, WA
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Sound Medical Research
Port Orchard, Washington 98366
960
mi
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Port Orchard, WA
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ActivMed Practices & Research, Inc.
Portsmouth, New Hampshire 03801
2591
mi
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Portsmouth, NH
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Wake Internal Medicine Consultants, Inc.
Raleigh, North Carolina 27612
2218
mi
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Raleigh, NC
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Superior Research LLC
Sacramento, California 95825
366
mi
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Sacramento, CA
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East Coast Institute for RSCH, St. Augustine Cardiology Associates, Research
Saint Augustine, Florida 32086
2161
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Saint Augustine, FL
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East Coast Institute for Research, LLC/ Baker-Gilmour Cardiovascular Institute
Saint Augustine, Florida 32086
2158
mi
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Saint Augustine, FL
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CentraCare Heart & Vascular Center @ St. Cloud Hospital
1406 6th Avenue North
Saint Cloud, Minnesota 56303
1485
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Saint Cloud, MN
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Washington University Center for Advanced Medicine
4921 Parkview Place
Saint Louis, Missouri 63110
1569
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Saint Louis, MO
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1569
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Saint Louis, MO
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Meridien Research
Saint Petersburg, Florida 33709
2128
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Saint Petersburg, FL
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Radiant Research
Santa Rosa, California 95405
397
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Santa Rosa, CA
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Cardiovascular Center of Sarasota
Sarasota, Florida 34239
2148
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Sarasota, FL
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Gulf Coast Medical Research, LLC
2225 Williams Trace Boulevard
Sugar Land, Texas 77478
1348
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Sugar Land, TX
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Meridien Research
Tampa, Florida
2136
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Tampa, FL
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