A Study of LY2623091 in Participants With High Blood Pressure



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 80
Updated:2/7/2015
Start Date:August 2014
End Date:August 2015
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
Phone:1-317-615-4559

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A Randomized, Placebo-Controlled, Double-Blinded, Parallel, Phase 2a Study to Evaluate the Safety and Efficacy of LY2623091 in Patients With Primary Hypertension

The main purpose of this study is to evaluate the safety and effectiveness of the study drug
known as LY2623091 in participants with high blood pressure.


Inclusion Criteria:

- Have a history of hypertension.

- If participants are naïve to treatment of hypertension, or have not been treated with
any antihypertensive medications within the 30 days immediately prior to screening:

- Have seated SBP of ≥140 and <170 millimeters of mercury (mmHg) at screening and
at the end of the lead-in period.

- If participants are currently being treated for hypertension:

- Are taking a stable dose of 1 or 2 antihypertensive medications for at least the
previous 30 days. A combination antihypertensive medication from 2 classes is
considered as 2 antihypertensive medications.

- Are willing to discontinue the antihypertensive medications during the study.

- Have seated SBP of ≥140 and <170 mmHg at the end of the lead-in period.

- Have a body mass index (BMI) ≥18.5 and <40 kilograms/m^2.

Exclusion Criteria:

- Have a history of severe hypertension (defined as SBP ≥180 mmHg and/or DBP ≥120
mmHg), secondary hypertension, symptomatic postural hypotension, or hospitalization
due to hypertension.

- Have SBP ≥180 mmHg and/or DBP ≥110 mmHg at screening, lead-in period, or
randomization.

- Have a history of hospitalization due to hyperkalemia, or history of drug
discontinuation due to elevated serum potassium levels.

- Have a serum potassium ≤3.5 or >5.0 millimoles per liter (mmol/L).

- Have an estimated glomerular filtration rate (eGFR) <50 milliliters/minute/1.73 m^2.
We found this trial at
33
sites
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
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99 N. Brice Rd
Columbus, Ohio 43068
614-501-6164
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4085 University Blvd S # 1
Jacksonville, Florida 32216
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1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
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Arlington Heights, Illinois 60005
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Auburn, Maine 04210
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Austin, Texas 78745
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Bellevue, Washington 98007
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Bossier, Louisiana 71111
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Charlotte, North Carolina 28204
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Chicago, Illinois 60607
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Cincinnati, Ohio 45219
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Cleveland, Ohio 44122
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Dayton, Ohio 45406
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Encinitas, California 92024
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Fargo, North Dakota 58103
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Fort Lauderdale, Florida 33308
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Glendale, Arizona 85306
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Greensboro, North Carolina 27408
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Greer, South Carolina 29651
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Honolulu, Hawaii 96814
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Indianapolis, Indiana 46260
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Las Vegas, Nevada 89119
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Muncie, Indiana 47304
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Oklahoma City, Oklahoma 73103
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Oklahoma City, Oklahoma 73210
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Rochester, New York 14609
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Round Rock, Texas 78681
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Sarasota, Florida 34239
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Tacoma, Washington 98405
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