Secondary Prevention of Small Subcortical Strokes Trial



Status:Archived
Conditions:High Blood Pressure (Hypertension), Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:Any
Updated:7/1/2011

Use our guide to learn which trials are right for you!

Secondary Prevention of Small Subcortical Strokes (SPS3) Trial


The goal of this study is to learn if combination antiplatelet therapy (aspirin and
clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and
cognitive decline, and if intensive blood pressure control is associated with fewer
recurrent strokes and cognitive decline.


Stroke is damage to the brain caused by problems in the blood vessels. Strokes often cause
paralysis, loss of sensation and speech, and other problems. A lacunar or small Subcortical
stroke affects the inner part of the brain causing small "pea sized" areas of damage due to
blockage of small blood vessels within the brain.

This multi-center study will recruit 3000 participants (20 percent of whom will be Hispanic)
to find out if using aspirin and clopidogrel is more effective than using aspirin alone to
prevent recurrent stroke in patients with lacunar stroke confirmed by MRI, and if lowering a
patient's blood pressure below the usual limits will also help prevent recurrent stroke and
maintain thinking ability. Both aspirin and clopidogrel are widely-used for blood clotting
and stroke prevention. Investigators intend to find out if using the drugs together is more
effective than using aspirin alone.

Participants will be randomly assigned to one of 2 types of treatment: either aspirin alone
or the combination of aspirin and clopidogrel. In addition, participants will be assigned to
one of 2 groups of blood pressure control. The difference between the two groups is the
target level of systolic blood pressure—either 130-149 or below 130. The goal of the blood
pressure aspect of this trial is to find out if lowering blood pressure after stroke helps
to prevent recurrent stroke and preserves cognition.


We found this trial at
38
sites
722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
?
mi
from
New York, NY
Click here to add this to my saved trials
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
8600 Old Georgetown Road
Bethesda, Maryland 20814
301-896-3100
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
1 Boston Medical Center Pl
Boston, Massachusetts 02118
617.638.8000
Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
?
mi
from
Boston, MA
Click here to add this to my saved trials
5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
?
mi
from
Miami, FL
Click here to add this to my saved trials
701 Park Avenue
Minneapolis, Minnesota 55404
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
Buffalo, New York
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
1 Cooper Plaza
Camden, New Jersey 08103
(856) 342-2000
Cooper University Hospital Cooper University Health Care, the clinical campus of Cooper Medical School of...
?
mi
from
Camden, NJ
Click here to add this to my saved trials
Cleveland, Ohio 44109
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Detroit, Michigan 48201
?
mi
from
Detroit, MI
Click here to add this to my saved trials
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Englewood, Colorado
?
mi
from
Englewood, CO
Click here to add this to my saved trials
Haverstraw, New York 10993
?
mi
from
Haverstraw, NY
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Knoxville, Tennessee 37934
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
Leavenworth, Kansas 66048
?
mi
from
Leavenworth, KS
Click here to add this to my saved trials
?
mi
from
Lexington, KY
Click here to add this to my saved trials
1000 N Oak Ave
Marshfield, Wisconsin 54449
(715) 387-5511
Marshfield Clinic - Marshfield Center The Clinic was incorporated under Wisconsin law in 1916 and...
?
mi
from
Marshfield, WI
Click here to add this to my saved trials
Melbourne, Florida
?
mi
from
Melbourne, FL
Click here to add this to my saved trials
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Phoenix, Arizona 85013
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
200 1st St SW
Rochester, Minnesota 55905
(507) 284-2316
Mayo Clinic College of Medicine Mayo Medical School enrolls a select class of 50 medical...
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Rochester, New York 14621
?
mi
from
Rochester, NY
Click here to add this to my saved trials
601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
?
mi
from
Rochester, NY
Click here to add this to my saved trials
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
?
mi
from
San Diego, CA
Click here to add this to my saved trials
500 Parnassus Ave
San Francisco, California 94143
(415) 476-9000
University of California at San Francisco (UCSF) The leading university exclusively focused on health, UC...
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
5777 E Mayo Blvd
Scottsdale, Arizona 85259
(480) 515-6296
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
?
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
Seattle, Washington 98195
(206) 543-2100
University of Washington Founded in 1861 by a private gift of 10 acres in what...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials