Secondary Prevention of Small Subcortical Strokes Trial



Status:Archived
Conditions:High Blood Pressure (Hypertension), Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:Any
Updated:7/1/2011

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Secondary Prevention of Small Subcortical Strokes (SPS3) Trial


The goal of this study is to learn if combination antiplatelet therapy (aspirin and
clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and
cognitive decline, and if intensive blood pressure control is associated with fewer
recurrent strokes and cognitive decline.


Stroke is damage to the brain caused by problems in the blood vessels. Strokes often cause
paralysis, loss of sensation and speech, and other problems. A lacunar or small Subcortical
stroke affects the inner part of the brain causing small "pea sized" areas of damage due to
blockage of small blood vessels within the brain.

This multi-center study will recruit 3000 participants (20 percent of whom will be Hispanic)
to find out if using aspirin and clopidogrel is more effective than using aspirin alone to
prevent recurrent stroke in patients with lacunar stroke confirmed by MRI, and if lowering a
patient's blood pressure below the usual limits will also help prevent recurrent stroke and
maintain thinking ability. Both aspirin and clopidogrel are widely-used for blood clotting
and stroke prevention. Investigators intend to find out if using the drugs together is more
effective than using aspirin alone.

Participants will be randomly assigned to one of 2 types of treatment: either aspirin alone
or the combination of aspirin and clopidogrel. In addition, participants will be assigned to
one of 2 groups of blood pressure control. The difference between the two groups is the
target level of systolic blood pressure—either 130-149 or below 130. The goal of the blood
pressure aspect of this trial is to find out if lowering blood pressure after stroke helps
to prevent recurrent stroke and preserves cognition.


We found this trial at
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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8600 Old Georgetown Road
Bethesda, Maryland 20814
301-896-3100
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
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1 Boston Medical Center Pl
Boston, Massachusetts 02118
617.638.8000
Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
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701 Park Avenue
Minneapolis, Minnesota 55404
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Buffalo, New York
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1 Cooper Plaza
Camden, New Jersey 08103
(856) 342-2000
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Cleveland, Ohio 44109
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
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Detroit, Michigan 48201
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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
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Englewood, Colorado
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Haverstraw, New York 10993
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Houston, Texas 77030
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Knoxville, Tennessee 37934
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Leavenworth, Kansas 66048
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1000 N Oak Ave
Marshfield, Wisconsin 54449
(715) 387-5511
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Melbourne, Florida
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8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
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722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Phoenix, Arizona 85013
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200 1st St SW
Rochester, Minnesota 55905
(507) 284-2316
Mayo Clinic College of Medicine Mayo Medical School enrolls a select class of 50 medical...
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Rochester, New York 14621
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601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
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500 Parnassus Ave
San Francisco, California 94143
(415) 476-9000
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5777 E Mayo Blvd
Scottsdale, Arizona 85259
(480) 515-6296
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
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Seattle, Washington 98195
(206) 543-2100
University of Washington Founded in 1861 by a private gift of 10 acres in what...
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1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
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