Integrated Cancer Repository for Cancer Research



Status:Recruiting
Conditions:Breast Cancer, Lung Cancer, Prostate Cancer, Colorectal Cancer, Colorectal Cancer, Colorectal Cancer, Colorectal Cancer, Skin Cancer, Ovarian Cancer, Cervical Cancer, Cervical Cancer, Liver Cancer, Liver Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Blood Cancer, Blood Cancer, Women's Studies, Endocrine, Gastrointestinal, Hematology, Endometrial Cancer, Kidney Cancer, Leukemia, Pancreatic Cancer, Bladder Cancer, Thyroid Cancer
Therapuetic Areas:Endocrinology, Gastroenterology, Hematology, Oncology, Reproductive
Healthy:No
Age Range:19 - 110
Updated:11/7/2018
Start Date:November 2013
End Date:December 2099
Contact:Whitney Goldner, MD
Email:wgoldner@unmc.edu
Phone:402-559-3579

Use our guide to learn which trials are right for you!

The objectives of this project at UNMC and other IRB approved sites is to implement and
maintain a comprehensive data and biospecimen bank known as the Integrated Cancer Repository
for Cancer Research (iCaRe2). The data registry and biospecimen bank will provide core
support services for future IRB approved multidisciplinary research on cancer and other
chronic diseases carried out by members of the Fred and Pamela Buffett Cancer Center as well
as internal and external research collaborators from different participating
institutions/centers.

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a
unique sociotechnical resource for the collection and management of cancer and health-related
data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center
(UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable
cancer data resource which is aimed at collecting, managing, mining and sharing the
comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens
(such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those
individuals.

The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for
data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the
ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies
(including clinical trials) performed in centers with expertise in cancer biology, pathology,
epidemiology, genetics, early detection, and patient care.

The iCaRe2 has been developed as an expansion of the biocomputing framework that initially
included four multi-center collaborative registries:

(i) the PCCR (Pancreatic Cancer Collaborative Registry that was established in 2001), (ii)
the BCCR (Breast Cancer Collaborative Registry - established in 2006 ); (iii) the TCCR
(Thyroid Cancer Collaborative Registry - established in 2006), and (iv) the GPHID (Great
Plains Health Informatics Database - established in 2011 to enroll subjects who have no
personal history of cancer diagnosis at the time of enrollment).

At present, this framework has been incrementally expanded to include the Thoracic Oncology
Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCaRe), Head and
Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer
Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR),
Leukemia and Myeloid Neoplasm Registry (LeMN) , Gynecological Cancer Collaborative Registry
(GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR) and
Auxiliary Cancer Registry (ACR).

The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry
or network model. It was felt that these latter models implied that the registry or network
would assume control of an individual Center's database. The major advantages of a
confederation model include the flexibility to use selected Centers for different research
projects based on a Center's resources and expertise and the ability to have different
strategies to address various research questions. It was also recognized that for this model
to be successful, it is essential to have a standardized approach to data collection (patient
information and biospecimen annotation) and reporting. A confederation would also encourage
participation of any interested Center, irrespective of its size or location. A web-based
registry iCaRe2 was developed and made available to any Center to participate in data
collection and storage of cancer related data.

Inclusion Criteria.

- Adult individuals (male and female) who have a personal diagnosis/history of cancer

- Adult individuals who have a risk for developing cancer or suspicious clinical
findings

- Adult individuals with no history of cancer for normal control registry.

- Able to provide consent.

- 19 years of age or older.

- Adult individuals who are able to speak English. Exclusion Criteria.

- Individuals under age 19.

- Individuals unable to provide informed consent by virtue of cognitive impairment.

- Anyone who does not meet the above inclusion criteria for this project.

- Non-English speaking individuals.
We found this trial at
70
sites
Daytona Beach, Florida 32117
Principal Investigator: T C Windham, MD, FACS
Phone: 386-231-4023
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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Minneapolis, Minnesota 55455
(612) 625-5000
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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Minneapolis, MN
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Phone: 412-623-4124
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Pittsburgh, PA
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3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Principal Investigator: Amy Krie, MD
Phone: 605-322-7600
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
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Sioux Falls, SD
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Aberdeen, South Dakota 57401
Principal Investigator: Richard Conklin, MD
Phone: 605-622-5613
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Aberdeen, SD
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Albany, New York 12208
Phone: 518-525-5087
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Albany, NY
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Anderson, Indiana 46011
Principal Investigator: Shiroo Parshad, MD
Phone: 765-298-2044
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Anderson, IN
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Anderson, Indiana 46011
Principal Investigator: Shiroo Parshad, MD
Phone: 765-298-2044
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Anderson, IN
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Anderson, Indiana 46011
Principal Investigator: Shiroo Parshad, MD
Phone: 765-298-2044
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Anderson, IN
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
Phone: 734-936-4775
University of Michigan Health System The University of Michigan is home to one of the...
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Aurora, Illinois 60507
Principal Investigator: Joseph T Meschi, MD
Phone: 630-978-6212
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Aurora, IL
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Baltimore, Maryland
Phone: 410-871-7450
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Brookfield, Wisconsin 53045
Principal Investigator: Jonathan Treisman, MD
Phone: 262-780-4347
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Colorado Springs, Colorado 80907
Principal Investigator: Kate Crow, MS CGC
Phone: 719-776-5270
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933 East Pierce Street
Council Bluffs, Iowa 51503
Phone: 712-396-4117
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Council Bluffs, IA
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Davenport, Iowa 52803
Phone: 563-421-1908
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Daytona Beach, Florida 32114
Phone: 386-254-4213
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Evanston, Illinois 60201
Phone: 847-570-1322
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Evanston, IL
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Fargo, North Dakota 58103
Phone: 218-786-1018
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Fargo, ND
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Fayetteville, North Carolina 28304
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Fort Wayne, Indiana 46805
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Fort Wayne, IN
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Franklin, Wisconsin 53132
Principal Investigator: Jonathan Treisman, MD
Phone: 414-427-2360
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Franklin, WI
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Genoa,
Phone: 390103538949
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Genoa,
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Glens Falls, New York 12801
Phone: 518-926-6701
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Grand Island, NE
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Hagerstown, Maryland 21740
Phone: 301-665-4682
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Hagerstown, MD
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Hastings, Nebraska 68901
Principal Investigator: Shamila Garg, MD
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Hastings, NE
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Holyoke, Massachusetts 01040
Principal Investigator: Zubeena Mateen, MD
Phone: 413-534-2500
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Holyoke, MA
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Indianapolis, Indiana 46256
Principal Investigator: Anuj Agarwala, MD
Phone: 317-497-2836
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Indianapolis, IN
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Indianapolis, Indiana 46227
Principal Investigator: Anuj Agarwala, MD
Phone: 317-497-2836
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Indianapolis, IN
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Indianapolis, Indiana 46256
Principal Investigator: Anuj Agarwala, MD
Phone: 317-497-2836
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Indianapolis, IN
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Joplin, Missouri 64804
Principal Investigator: Samir Dalia, MD
Phone: 417-556-3076
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Joplin, MO
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Kalispell, Montana 59901
Phone: 406-752-8669
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Kalispell, MT
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Kansas City, Missouri 64086
Principal Investigator: Timothy Pluard, MD
Phone: 816-287-6057
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Kansas City, MO
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Kansas City, Missouri 64118
Principal Investigator: Timothy Pluard, MD
Phone: 816-287-6057
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4321 Washington Street #4000
Kansas City, Missouri 64111
(816) 932-3300
Principal Investigator: Timothy Pluard, MD
Phone: 816-287-6057
Saint Luke's Cancer Institute Hope is an important part of the arsenal that helps patients...
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Kansas City, MO
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Kearney, Nebraska 68847
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Lewiston, Maine 04240
Phone: 207-795-8315
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Lewiston, ME
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Liberty, Missouri 64068
Principal Investigator: Timothy Pluard, MD
Phone: 816-287-6057
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Liberty, MO
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Lincoln, Nebraska 68510
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Lincoln, NE
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Marshall, Minnesota 56258
Phone: 507-537-9000
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Marshall, MN
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Mason City, Iowa 50401
Principal Investigator: Arvind Vemula, MD
Phone: 641-428-6304
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Mason City, IA
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Minot, North Dakota 58701
Principal Investigator: Michael Grant, MD
Phone: 701-857-3174
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Minot, ND
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Missoula, Montana 59802
Phone: 406-329-5652
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Missoula, MT
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Mitchell, South Dakota 57301
Principal Investigator: Stephan J Dick, MD
Phone: 605-995-5725
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Mitchell, SD
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500 John Deere Road
Moline, Illinois 61265
Phone: 309-779-5980
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Moline, IL
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New Orleans, Louisiana 70112
Phone: 504-988-6124
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New Orleans, LA
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 212-639-8714
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Norfolk, Nebraska 68701
Phone: 402-644-7534
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Norfolk, NE
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North Platte, Nebraska 69101
Principal Investigator: Irfan Vaziri, MD
Phone: 308-696-7386
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North Platte, NE
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8303 Dodge St
Omaha, Nebraska 68114
(402) 354-8124
Methodist Estabrook Cancer Center At Methodist Estabrook Cancer Center, we understand how deeply a diagnosis...
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Omaha, NE
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Emile St
Omaha, Nebraska 68198
(402) 559-4000
Phone: 402-559-3579
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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Omaha, NE
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Orange City, Florida 32763
Principal Investigator: T C Windham, MD, FACS
Phone: 386-231-4023
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Orange City, FL
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Overland Park, Kansas 66213
Principal Investigator: Timothy Pluard, MD
Phone: 816-287-6057
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Overland Park, KS
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60 Memorial Medical Parkway
Palm Coast, Florida 32164
Principal Investigator: T C Windham, MD, FACS
Phone: 386-231-4023
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Palm Coast, FL
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Plymouth, Massachusetts 02360
Principal Investigator: James M Koomey, MD
Phone: 508-732-8068
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Plymouth, MA
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Racine, Wisconsin 53405
Principal Investigator: Shayan Rayani, MD
Phone: 262-687-5057
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Racine, WI
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Rapid City, South Dakota 57701
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Rapid City, SD
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Rutland, Vermont 05701
Principal Investigator: Allan D Eisemann, MD
Phone: 802-747-1692
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Rutland, VT
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Saint Joseph, Missouri 64507
Phone: 816-271-7937
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Saint Joseph, MO
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Scottsbluff, Nebraska 69361
Principal Investigator: Vince Bjorling, MD
Phone: 308-630-2429
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Scottsbluff, NE
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Sioux Falls, South Dakota 57104
Phone: 605-328-8200
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Spencer, Iowa 51301
Principal Investigator: Glenn Preston
Phone: 712-264-8691
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Spencer, IA
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Utica, New York 13501
Phone: 315-624-5705
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Utica, NY
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Waterloo, Iowa 50702
Principal Investigator: Mohammed Masri, MD
Phone: 319-272-2388
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Waterloo, IA
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Wauwatosa, Wisconsin 53226
Principal Investigator: Jonathan Treisman, MD
Phone: 414-259-7486
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Wauwatosa, WI
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Westminster, Maryland 21157
Principal Investigator: Johanna DiMento, MD
Phone: 410-871-7450
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Westminster, MD
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Worcester, Massachusetts 01608
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Yorkville, Illinois 60560
Principal Investigator: Joseph T Meschi, MD
Phone: 630-978-6212
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Yorkville, IL
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